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Title
Novel actions of sclerostin on bone
Authors
Keywords
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Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume -, Issue -, Pages R167-R185
Publisher
Bioscientifica
Online
2018-12-12
DOI
10.1530/jme-18-0176
References
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Note: Only part of the references are listed.- Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size
- (2018) M. Kogawa et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- DKK1 and sclerostin are early markers of relapse in multiple myeloma
- (2018) Charlotte Mabille et al. BONE
- Dampening of the bone formation response following repeat dosing with sclerostin antibody in mice is associated with up-regulation of Wnt antagonists
- (2018) Gill Holdsworth et al. BONE
- Ex vivo replication of phenotypic functions of osteocytes through biomimetic 3D bone tissue construction
- (2018) Qiaoling Sun et al. BONE
- Structural and functional analysis of Dickkopf 4 (Dkk4): new insights into Dkk evolution and regulation of Wnt signalling by Dkk and Kremen proteins
- (2018) Saleha Patel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury
- (2018) Jiun C Chang et al. JOURNAL OF BONE AND MINERAL RESEARCH
- MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis
- (2017) Ernesto Canalis EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Emerging anabolic agents in the treatment of osteoporosis
- (2017) Christina Lovato et al. EXPERT OPINION ON EMERGING DRUGS
- Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia
- (2017) Wilson Cheuk Wing Chan et al. HUMAN MOLECULAR GENETICS
- Radial artery sclerostin expression in chronic kidney disease stage 5 predialysis patients: a cross-sectional observational study
- (2017) Hua Zhou et al. INTERNATIONAL UROLOGY AND NEPHROLOGY
- Sclerostin Antibody Administration Converts Bone Lining Cells Into Active Osteoblasts
- (2017) Sang Wan Kim et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The Skeleton Is a Storehouse of Mineral That Is Plundered During Lactation and (Fully?) Replenished Afterwards
- (2017) Christopher S Kovacs JOURNAL OF BONE AND MINERAL RESEARCH
- Skeletal energy homeostasis: a paradigm of endocrine discovery
- (2017) Karla J Suchacki et al. JOURNAL OF ENDOCRINOLOGY
- Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth
- (2017) J Delgado-Calle et al. LEUKEMIA
- Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis
- (2017) Kenneth G. Saag et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes
- (2017) Soohyun P. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow
- (2017) Alon Greenbaum et al. Science Translational Medicine
- Sclerostin antibodies in osteoporosis: latest evidence and therapeutic potential
- (2017) Michael R. McClung Therapeutic Advances in Musculoskeletal Disease
- Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and AtherosclerosisHighlights
- (2016) Smriti Murali Krishna et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- The systemic effects of sclerostin overexpression using ΦC31 integrase in mice
- (2016) Dongdong Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats
- (2016) Scott Taylor et al. BONE
- Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells
- (2016) Nicole M. Collette et al. BONE
- Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma
- (2016) J. Delgado-Calle et al. CANCER RESEARCH
- Osteocytes: The master cells in bone remodelling
- (2016) Matthew Prideaux et al. CURRENT OPINION IN PHARMACOLOGY
- Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
- (2016) Amy Y Sato et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease
- (2016) Homare Eda et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms
- (2016) Abhishek Chandra et al. JOURNAL OF BONE AND MINERAL RESEARCH
- A Novel Domain-Specific Mutation in a Sclerosteosis Patient Suggests a Role of LRP4 as an Anchor for Sclerostin in Human Bone
- (2016) Igor Fijalkowski et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys
- (2016) Michael S Ominsky et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Romosozumab Treatment in Postmenopausal Women with Osteoporosis
- (2016) Felicia Cosman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study
- (2016) Luc Chouinard et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Structural and functional insights into sclerostin-glycosaminoglycan interactions in bone
- (2015) Juliane Salbach-Hirsch et al. BIOMATERIALS
- Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats
- (2015) Michael S. Ominsky et al. BONE
- Sclerostin antibody and interval treadmill training effects in a rodent model of glucocorticoid-induced osteopenia
- (2015) Zahra Achiou et al. BONE
- LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion
- (2015) Nellie Y. Loh et al. Cell Metabolism
- Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model
- (2015) Yinshi Ren et al. FASEB JOURNAL
- The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytesin Vitro
- (2015) Jordan M. Spatz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sclerostin Antibody Preserves the Morphology and Structure of Osteocytes and Blocks the Severe Skeletal Deterioration After Motor-Complete Spinal Cord Injury in Rats
- (2015) Weiping Qin et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5
- (2015) Timur A Yorgan et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The WNT system: background and its role in bone
- (2015) U. H. Lerner et al. JOURNAL OF INTERNAL MEDICINE
- Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone
- (2015) Xiaolin Tu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways
- (2015) Wafa Bouaziz et al. ARTHRITIS RESEARCH & THERAPY
- An Overview of the Metabolic Functions of Osteocalcin
- (2015) Jianwen Wei et al. Current Osteoporosis Reports
- Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats
- (2014) Marina Stolina et al. BONE
- Bone marrow plasma macrophage inflammatory protein protein-1 alpha(MIP-1 alpha) and sclerostin in multiple myeloma: Relationship with bone disease and clinical characteristics
- (2014) Xiao-Tao Wang et al. LEUKEMIA RESEARCH
- Romosozumab in Postmenopausal Women with Low Bone Mineral Density
- (2014) Michael R. McClung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels
- (2014) Ming-Kang Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling
- (2013) Shane A. Lloyd et al. BONE
- Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans
- (2013) Matthew M. Roforth et al. BONE
- Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2
- (2013) Masakazu Kogawa et al. JOURNAL OF BONE AND MINERAL RESEARCH
- WNT signaling in bone homeostasis and disease: from human mutations to treatments
- (2013) Roland Baron et al. NATURE MEDICINE
- Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury
- (2012) Martine Roudier et al. ARTHRITIS AND RHEUMATISM
- Early Response of Bone Marrow Osteoprogenitors to Skeletal Unloading and Sclerostin Antibody
- (2012) Mohammad Shahnazari et al. CALCIFIED TISSUE INTERNATIONAL
- Sclerostin and Dickkopf-1 as Therapeutic Targets in Bone Diseases
- (2012) Hua Zhu Ke et al. ENDOCRINE REVIEWS
- Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors
- (2012) Gill Holdsworth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading
- (2012) Jordan M Spatz et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The complex world of WNT receptor signalling
- (2012) Christof Niehrs NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Sclerostin is overexpressed by plasma cells from multiple myeloma patients
- (2011) Giacomina Brunetti et al. Annals of the New York Academy of Sciences
- Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia
- (2011) Su Jin Kim et al. HUMAN GENETICS
- Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: Reduction post-bortezomib monotherapy
- (2011) Evangelos Terpos et al. INTERNATIONAL JOURNAL OF CANCER
- Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function
- (2011) Olivier Leupin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo
- (2011) Stacey M Woo et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism
- (2011) Gerald J Atkins et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Sclerostin and Its Association with Physical Activity, Age, Gender, Body Composition, and Bone Mineral Content in Healthy Adults
- (2011) Karin Amrein et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis
- (2011) B.Y. Chan et al. OSTEOARTHRITIS AND CARTILAGE
- The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells
- (2011) Dongxing Zhu et al. PLoS One
- Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway
- (2011) Asiri R. Wijenayaka et al. PLoS One
- Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
- (2011) Eric Bourhis et al. STRUCTURE
- Myeloma cells suppress osteoblasts through sclerostin secretion
- (2011) S Colucci et al. Blood Cancer Journal
- Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways
- (2010) Carola Krause et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6
- (2010) Eric Bourhis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sclerostin: A gem from the genome leads to bone-building antibodies
- (2010) Chris Paszty et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Proteomics Characterization of Extracellular Space Components in the Human Aorta
- (2010) Athanasios Didangelos et al. MOLECULAR & CELLULAR PROTEOMICS
- Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
- (2010) S. A. Ettenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NMR structure of the Wnt modulator protein Sclerostin
- (2009) Stella E. Weidauer et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Characterization of the Structural Features and Interactions of Sclerostin
- (2009) Vaclav Veverka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling
- (2009) Chuwen Lin et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Sclerostin in Mineralized Matrices and van Buchem Disease
- (2009) R.L. van Bezooijen et al. JOURNAL OF DENTAL RESEARCH
- Osteocyte Remodeling of the Perilacunar and Pericanalicular Matrix
- (2009) Hai Qing et al. International Journal of Oral Science
- Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
- (2008) Xiaodong Li et al. JOURNAL OF BONE AND MINERAL RESEARCH
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