Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

(2011) Shuo Chen et al.   DEVELOPMENTAL CELL

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

(2011) Zhihong Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

Structural Characterization of the Boca/Mesd Maturation Factors for LDL-Receptor-Type β Propeller Domains

(2011) Mark N. Collins et al.   STRUCTURE

Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6

(2011) Jianglei Chen et al.   STRUCTURE

The Structure of MESD45–184 Brings Light into the Mechanism of LDLR Family Folding

(2011) Christian Köhler et al.   STRUCTURE

Sclerostin binds and regulates the activity of cysteine-rich protein 61

(2010) Theodore A. Craig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mesd Is a Universal Inhibitor of Wnt Coreceptors LRP5 and LRP6 and Blocks Wnt/β-Catenin Signaling in Cancer Cells

(2010) Wenyan Lu et al.   BIOCHEMISTRY

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways

(2010) Carola Krause et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sclerostin: A gem from the genome leads to bone-building antibodies

(2010) Chris Paszty et al.   JOURNAL OF BONE AND MINERAL RESEARCH

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

(2010) N. Ouchi et al.   SCIENCE

NMR structure of the Wnt modulator protein Sclerostin

(2009) Stella E. Weidauer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Characterization of the Structural Features and Interactions of Sclerostin

(2009) Vaclav Veverka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

(2009) Maria Cristina Rosi et al.   JOURNAL OF NEUROCHEMISTRY

Proximal events in Wnt signal transduction

(2009) Stephane Angers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

(2009) Hong Y. Choi et al.   PLoS One

Wnt Signaling in Development, Disease and Translational Medicine

(2008) Gary Coombs et al.   CURRENT DRUG TARGETS

Wnt/β-catenin signaling: new (and old) players and new insights

(2008) He Huang et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6

(2008) Bryan T. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin D3

(2008) N Pendás-Franco et al.   ONCOGENE