Early Response of Bone Marrow Osteoprogenitors to Skeletal Unloading and Sclerostin Antibody

Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats

(2011) Fredrik Agholme et al.   Acta Orthopaedica

Sostdown-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

(2011) Gabriel L. Galea et al.   FEBS LETTERS

Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model

(2010) XiaoYan Tian et al.   BONE

Regulatory Mechanism of Osteoclastogenesis by RANKL and Wnt Signals

(2010) Naoyuki Takahashi   Frontiers in Bioscience-Landmark

Changes in markers of bone formation and resorption in a bed rest model of weightlessness

(2010) Sandra A. Lueken et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

(2010) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt signaling in bone metabolism

(2009) Takuo Kubota et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transient  -catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors

(2009) J. Valencia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transforming growth factor-β prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling

(2008) Cécilie Dufour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix Mineralization as a Trigger for Osteocyte Maturation

(2008) Kazuharu Irie et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects

(2006) Joseph E. Zerwekh et al.   JOURNAL OF BONE AND MINERAL RESEARCH