α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease
Authors
Keywords
αSyn 3H11, α-Synuclein, Lewy body, Glial cytoplasmic inclusion, Neurodegeneration, Exosome, Tunneling nanotube, Transmission, Astrocyte heterogeneity, NAC domain, Therapy
Journal
ACTA NEUROPATHOLOGICA
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-02-23
DOI
10.1007/s00401-019-01977-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Human astrocytes in the diseased brain
- (2018) Elena Dossi et al. BRAIN RESEARCH BULLETIN
- ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences
- (2018) W. Peelaerts et al. CELL AND TISSUE RESEARCH
- MANF protects dopamine neurons and locomotion defects from a human α-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways
- (2018) Zhuoyu Zhang et al. EXPERIMENTAL NEUROLOGY
- Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1
- (2018) Kurt A. Jellinger JOURNAL OF ALZHEIMERS DISEASE
- Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
- (2018) Chao Peng et al. NATURE
- Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
- (2018) Seung Pil Yun et al. NATURE MEDICINE
- Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies
- (2018) Chao Peng et al. NEUROBIOLOGY OF DISEASE
- Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies
- (2018) Y. Y. Fathy et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Astrocytes Attenuate Mitochondrial Dysfunctions in Human Dopaminergic Neurons Derived from iPSC
- (2018) Fang Du et al. Stem Cell Reports
- Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons
- (2018) Cecilia Chavarría et al. BIOCHEMICAL JOURNAL
- OUP accepted manuscript
- (2018) BRAIN
- Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration
- (2018) Zachary A. Sorrentino et al. NEUROBIOLOGY OF DISEASE
- Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions
- (2018) Zachary A. Sorrentino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Therapeutic approaches to target alpha-synuclein pathology
- (2017) Patrik Brundin et al. EXPERIMENTAL NEUROLOGY
- The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases
- (2017) Guiliana Soraya Victoria et al. JOURNAL OF CELL BIOLOGY
- Cografting astrocytes improves cell therapeutic outcomes in a Parkinson’s disease model
- (2017) Jae-Jin Song et al. JOURNAL OF CLINICAL INVESTIGATION
- Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
- (2017) Jinar Rostami et al. JOURNAL OF NEUROSCIENCE
- Overexpression of α-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis
- (2017) Adolfo Garcia Erustes et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein
- (2017) Theodore A. Sarafian et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
- (2017) Dilan Athauda et al. LANCET
- Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
- (2017) Veronica Lindström et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
- (2017) Zachary A. Sorrentino et al. Molecular Neurodegeneration
- Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
- (2017) Emily J. Koller et al. Molecular Neurodegeneration
- T cells from patients with Parkinson’s disease recognize α-synuclein peptides
- (2017) David Sulzer et al. NATURE
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- Selective neuronal vulnerability in Parkinson disease
- (2017) D. James Surmeier et al. NATURE REVIEWS NEUROSCIENCE
- Animal models of α-synucleinopathy for Parkinson disease drug development
- (2017) James B. Koprich et al. NATURE REVIEWS NEUROSCIENCE
- In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains
- (2017) Fabio Cavaliere et al. NEUROBIOLOGY OF DISEASE
- Cell Biology of Astrocyte-Synapse Interactions
- (2017) Nicola J. Allen et al. NEURON
- The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
- (2017) Heather D.E. Booth et al. TRENDS IN NEUROSCIENCES
- Metabolism of Dopamine in Nucleus Accumbens Astrocytes Is Preserved in Aged Mice Exposed to MPTP
- (2017) Brittany M. Winner et al. Frontiers in Aging Neuroscience
- Parkinson disease
- (2017) Werner Poewe et al. Nature Reviews Disease Primers
- Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
- (2017) Jennifer Ngolab et al. Acta Neuropathologica Communications
- Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson’s disease
- (2017) Martina Barrenschee et al. Acta Neuropathologica Communications
- A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
- (2017) Jess-Karan S. Dhillon et al. PLoS One
- α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients
- (2017) Birger Victor Dieriks et al. Scientific Reports
- Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type
- (2017) Elisabet Ihse et al. Scientific Reports
- Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies
- (2016) Laura Pieri et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology
- (2016) Ricardo Taipa et al. BRAIN
- Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration
- (2016) Michel Goedert et al. BRAIN
- Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
- (2016) Timothy R. Sampson et al. CELL
- The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
- (2016) Dilan Athauda et al. DRUG DISCOVERY TODAY
- Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes
- (2016) Saïda Abounit et al. EMBO JOURNAL
- Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild-type DJ-1
- (2016) Waka Kojima et al. GENES TO CELLS
- Ca2+is a key factor in α-synuclein-induced neurotoxicity
- (2016) Plamena R. Angelova et al. JOURNAL OF CELL SCIENCE
- Structural disorder of monomeric α-synuclein persists in mammalian cells
- (2016) Francois-Xavier Theillet et al. NATURE
- Extracellular vesicles round off communication in the nervous system
- (2016) Vivian Budnik et al. NATURE REVIEWS NEUROSCIENCE
- Neurotrophic factor therapy for Parkinson′s disease: past, present and future
- (2016) AideenM Sullivan et al. Neural Regeneration Research
- Glia and alpha-synuclein in neurodegeneration: A complex interaction
- (2016) Dominik Brück et al. NEUROBIOLOGY OF DISEASE
- Review: The spectrum of clinical features seen with alpha synuclein pathology
- (2016) R. A. Barker et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds
- (2016) Isabel Denzer et al. PHARMACOLOGICAL RESEARCH
- Pathological -synuclein transmission initiated by binding lymphocyte-activation gene 3
- (2016) X. Mao et al. SCIENCE
- Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
- (2015) Toshiki Uchihara et al. ACTA NEUROPATHOLOGICA
- Astrocytes: a central element in neurological diseases
- (2015) Milos Pekny et al. ACTA NEUROPATHOLOGICA
- Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes
- (2015) Emmy H. Rannikko et al. BMC NEUROSCIENCE
- -synuclein assemblies sequester neuronal 3-Na+/K+-ATPase and impair Na+ gradient
- (2015) A. N. Shrivastava et al. EMBO JOURNAL
- Nrf2—a therapeutic target for the treatment of neurodegenerative diseases
- (2015) Delinda A. Johnson et al. FREE RADICAL BIOLOGY AND MEDICINE
- Astrocyte development: A Guide for the Perplexed
- (2015) Anna Victoria Molofsky et al. GLIA
- The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers
- (2015) Cristiane Latge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Delineating nonmotor symptoms in early Parkinson's disease and first-degree relatives
- (2015) Fahd Baig et al. MOVEMENT DISORDERS
- Colonic bacterial composition in Parkinson's disease
- (2015) Ali Keshavarzian et al. MOVEMENT DISORDERS
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Diversity of astrocyte functions and phenotypes in neural circuits
- (2015) Baljit S Khakh et al. NATURE NEUROSCIENCE
- Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors
- (2015) Lisa Klingelhoefer et al. Nature Reviews Neurology
- Oxidative and nitrative stress in neurodegeneration
- (2015) Catherine A. Cobb et al. NEUROBIOLOGY OF DISEASE
- Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation
- (2015) Junchao Tong et al. NEUROBIOLOGY OF DISEASE
- Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration
- (2015) Keiko Nakamura et al. NEUROPATHOLOGY
- A survey of human brain transcriptome diversity at the single cell level
- (2015) Spyros Darmanis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Astrocytes tell neurons when to listen up
- (2015) A. H. Gittis et al. SCIENCE
- Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases
- (2015) Ronald Melki Journal of Parkinsons Disease
- Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease
- (2015) Iciar Aviles-Olmos et al. Journal of Parkinsons Disease
- Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
- (2014) Ghazaleh Ashrafi et al. JOURNAL OF CELL BIOLOGY
- Brain Injection of -Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker
- (2014) A. N. Sacino et al. JOURNAL OF NEUROSCIENCE
- Gut microbiota are related to Parkinson's disease and clinical phenotype
- (2014) Filip Scheperjans et al. MOVEMENT DISORDERS
- Intramuscular injection of -synuclein induces CNS -synuclein pathology and a rapid-onset motor phenotype in transgenic mice
- (2014) A. N. Sacino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solution conditions determine the relative importance of nucleation and growth processes in -synuclein aggregation
- (2014) A. K. Buell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease
- (2014) L Zondler et al. Cell Death & Disease
- Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour
- (2014) Giuliana Fusco et al. Nature Communications
- Alpha-synuclein biology in Lewy body diseases
- (2014) Woojin Scott Kim et al. Alzheimers Research & Therapy
- iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
- (2014) Chris M. Woodard et al. Cell Reports
- Pink1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced akt and increased p38 mapk activation, and downregulation of egfr
- (2013) Insup Choi et al. GLIA
- Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
- (2013) Patrick Ejlerskov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling
- (2013) Myriam M. Ouberai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Conformational templating of α-synuclein aggregates in neuronal-glial cultures
- (2013) Amanda N Sacino et al. Molecular Neurodegeneration
- Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects
- (2013) Madison T. Gray et al. MOVEMENT DISORDERS
- The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson’s disease: a review of in vivo models
- (2013) Hiroyasu Sato et al. REVIEWS IN THE NEUROSCIENCES
- Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts
- (2013) Nady Braidy et al. Translational Neurodegeneration
- An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology
- (2012) Gabor G. Kovacs et al. ACTA NEUROPATHOLOGICA
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
- (2012) Isabel Lastres-Becker et al. HUMAN MOLECULAR GENETICS
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Activity-dependent secretion of alpha-synuclein by enteric neurons
- (2012) Sébastien Paillusson et al. JOURNAL OF NEUROCHEMISTRY
- Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model
- (2012) L. Gan et al. JOURNAL OF NEUROSCIENCE
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity
- (2012) Tracy P. Williamson et al. NEUROTOXICOLOGY
- The chaperone activity of α-synuclein: Utilizing deletion mutants to map its interaction with target proteins
- (2012) Agata Rekas et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons
- (2012) M. Decressac et al. Science Translational Medicine
- Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
- (2012) Yoichi Imaizumi et al. Molecular Brain
- Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism
- (2011) Agnieszka Jazwa et al. ANTIOXIDANTS & REDOX SIGNALING
- α-Synuclein misfolding and Parkinson's disease
- (2011) Leonid Breydo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
- (2011) Ha Nam Nguyen et al. Cell Stem Cell
- Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease
- (2011) Wenbo Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein
- (2011) Takafumi Hasegawa et al. PLoS One
- Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update
- (2010) Kurt A. Jellinger et al. ACTA NEUROPATHOLOGICA
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
- (2010) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease
- (2010) Pablo Garcia-Reitböck et al. BRAIN
- Keap1-Nrf2 activation in the presence and absence of DJ-1
- (2010) Li Gan et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions
- (2010) Ara Jang et al. JOURNAL OF NEUROCHEMISTRY
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1
- (2010) Nadia G. Innamorato et al. PLoS One
- Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice
- (2010) Xing-Long Gu et al. Molecular Brain
- SNCAvariants are associated with increased risk for multiple system atrophy
- (2009) Sonja W. Scholz et al. ANNALS OF NEUROLOGY
- Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation
- (2009) Junchao Tong et al. BRAIN
- A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death
- (2009) Kaoru Saijo et al. CELL
- Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation
- (2009) Tu-Hsueh Yeh et al. GLIA
- Degeneration in Different Parkinsonian Syndromes Relates to Astrocyte Type and Astrocyte Protein Expression
- (2009) Yun Ju C. Song et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- GFAP reactivity, apolipoprotein E redistribution and cholesterol reduction in human astrocytes treated with α-synuclein
- (2009) Andrew O. Koob et al. NEUROSCIENCE LETTERS
- Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
- (2009) Pei-Chun Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tripartite synapses: astrocytes process and control synaptic information
- (2009) Gertrudis Perea et al. TRENDS IN NEUROSCIENCES
- Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2D3receptor activation
- (2008) Arianna Bellucci et al. JOURNAL OF NEUROCHEMISTRY
- Nurr1 transcriptionally regulates the expression of ??-synuclein
- (2008) Yan Xiang Yang et al. NEUROREPORT
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now