Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion

(2017) Xander M. van Wijk et al.   mBio

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease

(2016) Chia-Chen Liu et al.   Science Translational Medicine

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis

(2014) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice

(2014) Charlotte B. Jendresen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Caudo-rostral brain spreading of α-synuclein through vagal connections

(2013) Ayse Ulusoy et al.   EMBO Molecular Medicine

Heparan sulfate 3-O-sulfation: A rare modification in search of a function

(2013) Bryan E. Thacker et al.   MATRIX BIOLOGY

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain

(2012) Xiao Zhang et al.   ACTA NEUROPATHOLOGICA

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Glycosaminoglycans, Protein Aggregation and Neurodegeneration

(2011) Dulce Papy-Garcia et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

(2011) Malin K. Sandberg et al.   NATURE

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

(2011) Jeffrey H. Kordower et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells

(2011) Thomas Näsström et al.   PLoS One

Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

(2011) F. Noborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid in neurodegenerative diseases: Friend or foe?

(2011) Katie J. Wolfe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

(2010) Elina Sandwall et al.   GLYCOBIOLOGY

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE