Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions

The genetics of Parkinson disease

(2018) Hao Deng et al.   AGEING RESEARCH REVIEWS

Is Parkinson’s disease a lysosomal disorder?

(2018) Andrés D Klein et al.   BRAIN

The effect of truncation on prion-like properties of α-synuclein

(2018) Makoto Terada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localized induction of wild-type and mutant alpha-synuclein aggregation reveals propagation along neuroanatomical tracts

(2018) Jacob I. Ayers et al.   JOURNAL OF VIROLOGY

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

(2018) Diego Grassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

(2018) Caterina Masaracchia et al.   Acta Neuropathologica Communications

Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice

(2017) Nicola J Rutherford et al.   HUMAN MOLECULAR GENETICS

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

(2017) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets

(2017) Aditya Iyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

(2017) Zachary A. Sorrentino et al.   Molecular Neurodegeneration

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

(2017) Hisham Abdelmotilib et al.   NEUROBIOLOGY OF DISEASE

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

(2017) Kevin H. Strang et al.   Acta Neuropathologica Communications

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies

(2017) Jess-Karan S. Dhillon et al.   PLoS One

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein

(2016) Farah El-Turk et al.   BIOCHEMISTRY

Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies

(2016) Laura Pieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Neuroinflammation in Synucleinopathies

(2016) Somin Lim et al.   BRAIN PATHOLOGY

Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology

(2016) Amanda N. Sacino et al.   JOURNAL OF NEUROCHEMISTRY

Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease

(2016) Yvette C. Wong et al.   MOVEMENT DISORDERS

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

(2016) Marija Iljina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

(2016) Kelvin C. Luk et al.   Cell Reports

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

(2016) Hugo J.R. Fernandes et al.   Stem Cell Reports

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Toshiki Uchihara et al.   ACTA NEUROPATHOLOGICA

Behavioural deficits in transgenic mice expressing human truncated (1–120 amino acid) alpha-synuclein

(2015) Katie Hall et al.   EXPERIMENTAL NEUROLOGY

The role of the acidic domain of α-synuclein in amyloid fibril formation: a molecular dynamics study

(2015) SeongByeong Park et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils

(2015) Atsushi Tsujimura et al.   NEUROBIOLOGY OF DISEASE

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

(2015) Ryan P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates

(2015) E-J Bae et al.   Cell Death & Disease

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

(2014) Amanda N. Sacino et al.   ACTA NEUROPATHOLOGICA

Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein

(2014) Naoto Sugeno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity

(2014) Ossama Khalaf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unlike Twins: An NMR Comparison of Two α-Synuclein Polymorphs Featuring Different Toxicity

(2014) Julia Gath et al.   PLoS One

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

(2014) John F. Kellie et al.   Scientific Reports

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

(2013) Dorothea Pinotsi et al.   NANO LETTERS

Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson's Disease Associated Mutations A53T and E46K

(2013) Luisel R. Lemkau et al.   PLoS One

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

(2013) Amanda N Sacino et al.   Acta Neuropathologica Communications

Critical Role of Truncated α-Synuclein and Aggregates in Parkinson's Disease and Incidental Lewy Body Disease

(2012) Kavita Prasad et al.   BRAIN PATHOLOGY

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein

(2012) Yasutaka Izawa et al.   Brain and Behavior

Residue-Specific Fluorescent Probes of α-Synuclein: Detection of Early Events at the N- and C-Termini during Fibril Assembly

(2011) Thai Leong Yap et al.   BIOCHEMISTRY

E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment

(2011) Kristel L. Emmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Matrix Metalloproteinase 3-mediated α-Synuclein Cleavage in Dopaminergic Cell Death

(2011) Dong-Hee Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein

(2011) Katerina Levitan et al.   JOURNAL OF MOLECULAR BIOLOGY

N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast

(2011) Katherina Vamvaca et al.   JOURNAL OF NEUROCHEMISTRY

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

α-synuclein phosphorylation and truncation are normal events in the adult human brain

(2011) G. Muntané et al.   NEUROSCIENCE

The Conformation and the Aggregation Kinetics of α-Synuclein Depend on the Proline Residues in Its C-Terminal Region

(2010) Jessika Meuvis et al.   BIOCHEMISTRY

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease

(2010) Pablo Garcia-Reitböck et al.   BRAIN

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology

(2010) Ayse Ulusoy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A novel, high-efficiency cellular model of fibrillar α-synuclein inclusions and the examination of mutations that inhibit amyloid formation

(2010) Elisa A. Waxman et al.   JOURNAL OF NEUROCHEMISTRY

Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions

(2010) Ara Jang et al.   JOURNAL OF NEUROCHEMISTRY

Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

(2009) João Daher et al.   Molecular Neurodegeneration

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of antibodies that selectively detect α-synuclein in pathological inclusions

(2008) Elisa A. Waxman et al.   ACTA NEUROPATHOLOGICA

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice

(2006) Masaki Wakamatsu et al.   NEUROBIOLOGY OF AGING