The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis

Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate

(2018) Durga M. S. H. Chandrupatla et al.   Contrast Media & Molecular Imaging

Experimental animal models for rheumatoid arthritis

(2018) Narayan Choudhary et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus

(2018) Nehal Narayan et al.   JOURNAL OF NUCLEAR MEDICINE

Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases

(2018) Scott Poh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting B Cells and Plasma Cells in Autoimmune Diseases

(2018) Katharina Hofmann et al.   Frontiers in Immunology

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

(2018) Jiajie Tu et al.   Frontiers in Immunology

Lactoferrin-Containing Immunocomplexes Drive the Conversion of Human Macrophages from M2- into M1-like Phenotype

(2018) Chen-Hui Gao et al.   Frontiers in Immunology

Folate Receptor–Targeted Single-Photon Emission Computed Tomography/Computed Tomography to Detect Activated Macrophages in Atherosclerosis: Can It Distinguish Vulnerable from Stable Atherosclerotic Plaques?

(2018) Leah C.J. Winkel et al.   Molecular Imaging

Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel 18 F-Folate Radiotracer

(2018) Adrienne Müller et al.   Molecular Imaging

Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations

(2017) Claire Tronel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Forward to the Past: The Case for Quantitative PET Imaging

(2017) Adriaan A. Lammertsma   JOURNAL OF NUCLEAR MEDICINE

Therapeutic Impact of Nanoparticle Therapy Targeting Tumor-Associated Macrophages

(2017) Courtney A. Penn et al.   MOLECULAR CANCER THERAPEUTICS

Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [11C]PK11195 and [11C]Ketoprofen Tracers

(2017) Satoshi Nozaki et al.   MOLECULAR IMAGING AND BIOLOGY

Synovial tissue research: a state-of-the-art review

(2017) Carl Orr et al.   Nature Reviews Rheumatology

Advances in positron emission tomography for the imaging of rheumatoid arthritis

(2017) Nehal Narayan et al.   RHEUMATOLOGY

FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer

(2017) Esteban A. Orellana et al.   Science Translational Medicine

Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis

(2016) Cristina Municio et al.   ANNALS OF THE RHEUMATIC DISEASES

Among human macrophages polarised to different phenotypes, the M-CSF-oriented cells present the highest pro-inflammatory response to the rheumatoid arthritis-specific immune complexes containing ACPA

(2016) Cyril Clavel et al.   ANNALS OF THE RHEUMATIC DISEASES

2016 update of the EULAR recommendations for the management of early arthritis

(2016) Bernard Combe et al.   ANNALS OF THE RHEUMATIC DISEASES

Diagnosis and management of rheumatoid arthritis; What is the current role of established and new imaging techniques in clinical practice?

(2016) Maria Antonietta D'Agostino et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages

(2016) Mariam Mohammadi et al.   JOURNAL OF CONTROLLED RELEASE

Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen

(2016) Christian Machacek et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity

(2016) R C Lynn et al.   LEUKEMIA

Biomarkers of in vivo fluorescence imaging in allergic airway inflammation

(2016) Fa-Ping Wang et al.   MOLECULAR AND CELLULAR PROBES

Synthesis and Preclinical Evaluation of Folate-NOTA-Al18F for PET Imaging of Folate-Receptor-Positive Tumors

(2016) Qingshou Chen et al.   MOLECULAR PHARMACEUTICS

Folate-targeted nanoparticles for rheumatoid arthritis therapy

(2016) Eugénia Nogueira et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanism of action of methotrexate in rheumatoid arthritis and the search for biomarkers

(2016) Philip M. Brown et al.   Nature Reviews Rheumatology

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

Activated macrophage-targeted dextran–methotrexate/folate conjugate prevents deterioration of collagen-induced arthritis in mice

(2016) Modi Yang et al.   Journal of Materials Chemistry B

Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases

(2016) Young-Su Yi   Immune Network

Molecular Imaging of Folate Receptor β–Positive Macrophages during Acute Lung Inflammation

(2015) Wei Han et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis

(2015) Priscilla F Kerkman et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting of folate receptor   on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells

(2015) R. C. Lynn et al.   BLOOD

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice

(2015) Eugénia Nogueira et al.   Journal of Biomedical Nanotechnology

Imaging Microglial Activation with TSPO PET: Lighting Up Neurologic Diseases?

(2015) L. Vivash et al.   JOURNAL OF NUCLEAR MEDICINE

Predicting Response to Therapy for Autoimmune and Inflammatory Diseases Using a Folate Receptor-Targeted Near-Infrared Fluorescent Imaging Agent

(2015) Lindsay E. Kelderhouse et al.   MOLECULAR IMAGING AND BIOLOGY

Novel insights in folate receptors and transporters: implications for disease and treatment of immune diseases and cancer

(2015) Gerrit Jansen et al.   PTERIDINES

Triamcinolone acetonide activates an anti-inflammatory and folate receptor–positive macrophage that prevents osteophytosis in vivo

(2015) Michiel Siebelt et al.   ARTHRITIS RESEARCH & THERAPY

Subclinical synovitis detected by macrophage PET, but not MRI, is related to short-term flare of clinical disease activity in early RA patients: an exploratory study

(2015) Yoony Y. J. Gent et al.   ARTHRITIS RESEARCH & THERAPY

Expression of folate receptors alpha and beta in normal and cancerous gynecologic tissues: correlation of expression of the beta isoform with macrophage markers

(2015) Daniel J O’Shannessy et al.   Journal of Ovarian Research

The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

The folate receptor as a rational therapeutic target for personalized cancer treatment

(2014) Yehuda G. Assaraf et al.   DRUG RESISTANCE UPDATES

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

The identification and developmental requirements of colonic CD169+macrophages

(2014) Ida H. Hiemstra et al.   IMMUNOLOGY

Pemetrexed Ameliorates Experimental Arthritis in Rats

(2014) Ahmet Karatas et al.   INFLAMMATION

Folate receptor-β constitutes a marker for human proinflammatory monocytes

(2014) Jiayin Shen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophage uptake and accumulation of folates are polarization-dependent in vitro and in vivo and are regulated by activin A

(2014) Rafael Samaniego et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evaluation of antitumor effect of zoledronic acid entrapped in folate-linked liposome for targeting to tumor-associated macrophages

(2014) Yoshiyuki Hattori et al.   JOURNAL OF LIPOSOME RESEARCH

Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter

(2014) Lalit K. Golani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Folate Receptor-  Imaging Using 99mTc-Folate to Explore Distribution of Polarized Macrophage Populations in Human Atherosclerotic Plaque

(2014) N. A. Jager et al.   JOURNAL OF NUCLEAR MEDICINE

Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile

(2014) Blanca Soler Palacios et al.   JOURNAL OF PATHOLOGY

In vivo optical imaging of folate receptor-β in head and neck squamous cell carcinoma

(2014) Joel Y. Sun et al.   LARYNGOSCOPE

Effect of Receptor Occupancy on Folate Receptor Internalization

(2014) N. Achini Bandara et al.   MOLECULAR PHARMACEUTICS

Folate Receptor-β in Activated Macrophages: Ligand Binding and Receptor Recycling Kinetics

(2014) Bindu Varghese et al.   MOLECULAR PHARMACEUTICS

[18F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model

(2014) Géraldine Pottier et al.   ARTHRITIS RESEARCH & THERAPY

Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis

(2014) Yoony YJ Gent et al.   ARTHRITIS RESEARCH & THERAPY

Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages

(2014) Lisa T. C. Vogelpoel et al.   Nature Communications

Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis

(2013) Jing Shi et al.   ANNALS OF THE RHEUMATIC DISEASES

Methotrexate Normalizes Up-Regulated Folate Pathway Genes in Rheumatoid Arthritis

(2013) Marjolein Blits et al.   ARTHRITIS AND RHEUMATISM

Augmented sensitivity to methotrexate by curcumin induced overexpression of folate receptor in KG-1 cells

(2013) Sugapriya Dhanasekaran et al.   BIOCHIMIE

Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis

(2013) Yingjuan Lu et al.   CLINICAL IMMUNOLOGY

Towards a Successful Clinical Implementation of Fluorescence-Guided Surgery

(2013) T. J. A. Snoeks et al.   MOLECULAR IMAGING AND BIOLOGY

Use of Folate-Conjugated Imaging Agents To Target Alternatively Activated Macrophages in a Murine Model of Asthma

(2013) Jiayin Shen et al.   MOLECULAR PHARMACEUTICS

Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes

(2013) Nicolai A. Kittan et al.   PLoS One

Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition

(2013) A. S. Wibowo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methotrexate analogues display enhanced inhibition of TNF-α production in whole blood from RA patients

(2013) JW van der Heijden et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Present Role of Positron Emission Tomography in the Diagnosis and Monitoring of Peripheral Inflammatory Arthritis: A Systematic Review

(2013) S. T. G. Bruijnen et al.   ARTHRITIS CARE & RESEARCH

Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis

(2013) Yoony YJ Gent et al.   ARTHRITIS RESEARCH & THERAPY

Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis - a systematic review of the literature

(2013) David F Ten Cate et al.   ARTHRITIS RESEARCH & THERAPY

Clinical Significance of Folate Receptor β–expressing Tumor-associated Macrophages in Pancreatic Cancer

(2012) Hiroshi Kurahara et al.   ANNALS OF SURGICAL ONCOLOGY

[18F]Fluoro-Deoxy-Glucose Folate: A Novel PET Radiotracer with Improved in Vivo Properties for Folate Receptor Targeting

(2012) Cindy R. Fischer et al.   BIOCONJUGATE CHEMISTRY

Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

(2012) Nitzan Gonen et al.   DRUG RESISTANCE UPDATES

Correlation of 18F-FDG PET/CT assessments with disease activity and markers of inflammation in patients with early rheumatoid arthritis following the initiation of combination therapy with triple oral antirheumatic drugs

(2012) Anne Roivainen et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Noninvasive Molecular Imaging of Neuroinflammation

(2012) Andreas H Jacobs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Imaging Sites of Infection Using a 99mTc-Labeled Folate Conjugate Targeted to Folate Receptor Positive Macrophages

(2012) Walter A. Henne et al.   MOLECULAR PHARMACEUTICS

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

(2012) J.-L. Davignon et al.   RHEUMATOLOGY

Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

(2012) E. Choy   RHEUMATOLOGY

Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles

(2012) Y Tsuneyoshi et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis

(2012) Carmen A Ambarus et al.   ARTHRITIS RESEARCH & THERAPY

Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis

(2012) Taku Nagai et al.   ARTHRITIS RESEARCH & THERAPY

Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β–Expressing Macrophages

(2012) Yuko Furusho et al.   Journal of the American Heart Association

Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography

(2011) Tom M. Piscaer et al.   ARTHRITIS AND RHEUMATISM

Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis

(2011) Thommey P. Thomas et al.   ARTHRITIS AND RHEUMATISM

Development of the anti-citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis

(2011) Lotte A. van de Stadt et al.   ARTHRITIS AND RHEUMATISM

Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: Findings of a prospective pilot study

(2011) Yoony Y. J. Gent et al.   ARTHRITIS AND RHEUMATISM

In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site

(2011) Jessica M. Haverkamp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

(2011) C.A. Ambarus et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Increased cerebral (R)-[11C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study

(2011) Hedy Folkersma et al.   Journal of Neuroinflammation

Indocyanine Green-Containing Nanostructure as Near Infrared Dual-Functional Targeting Probes for Optical Imaging and Photothermal Therapy

(2011) Xiaohui Zheng et al.   MOLECULAR PHARMACEUTICS

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

(2011) Gooitzen M van Dam et al.   NATURE MEDICINE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate

(2011) Yingjuan Lu et al.   ARTHRITIS RESEARCH & THERAPY

Macrophages in Synovial Inflammation

(2011) Aisling Kennedy et al.   Frontiers in Immunology

Imaging of Atherosclerosis in Apoliprotein E Knockout Mice: Targeting of a Folate-Conjugated Radiopharmaceutical to Activated Macrophages

(2010) W. Ayala-Lopez et al.   JOURNAL OF NUCLEAR MEDICINE

18F-FDG PET as a Tool to Predict the Clinical Outcome of Infliximab Treatment of Rheumatoid Arthritis: An Explorative Study

(2010) E. H. Elzinga et al.   JOURNAL OF NUCLEAR MEDICINE

Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study

(2009) W. H. Bos et al.   ANNALS OF THE RHEUMATIC DISEASES

Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

(2009) Joost W. Van Der Heijden et al.   ARTHRITIS AND RHEUMATISM

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

(2009) John A. Hamilton et al.   ARTHRITIS AND RHEUMATISM

Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor β

(2009) Taku Nagai et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Animal models of rheumatoid arthritis

(2009) Darren L. Asquith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation

(2009) F. Chauveau et al.   JOURNAL OF NUCLEAR MEDICINE

[11C]-DPA-713 and [18F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [11C]-(R)-PK11195 in a Rat Model of Herpes Encephalitis

(2009) Janine Doorduin et al.   MOLECULAR IMAGING AND BIOLOGY

Immunity to Citrullinated Proteins in Rheumatoid Arthritis

(2008) Lars Klareskog et al.   Annual Review of Immunology

Noninvasive imaging of macrophages in rheumatoid synovitis using11C-(R)-PK11195 and positron emission tomography

(2008) Conny J. van der Laken et al.   ARTHRITIS AND RHEUMATISM

A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages

(2008) W. Xia et al.   BLOOD

Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo

(2008) Robert Mauritz et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritis

(2008) M. A. Kropholler et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

(2008) Fabien Chauveau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

DPA-714, a New Translocator Protein-Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic Characterization

(2008) M. L. James et al.   JOURNAL OF NUCLEAR MEDICINE

Expression of CD68 in Non-Myeloid Cell Types

(2008) E. Gottfried et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH