Review
Immunology
Ting Zhao, Zhaohu Xie, Yujiang Xi, Li Liu, Zhaofu Li, Dongdong Qin
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by genetics and environmental factors. Rodent models are commonly used for RA research, but genetic differences between rodents and humans lead to inconsistent results, requiring exploration of new models. Non-human primates (NHPs), which share closer similarities to humans in terms of immune system, metabolic conditions, and genetic makeup, offer a powerful tool for studying RA development and drug development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Eunji Ha, Sang-Cheol Bae, Kwangwoo Kim
Summary: A large trans-ancestral meta-analysis identified 11 new susceptibility loci for RA, explaining a significant portion of the heritability in East Asians and Europeans, and confirmed 71 known non-HLA susceptibility loci. The study also highlighted the importance of CD4(+) T-cell activation and potential non-immune organs in RA pathogenesis, providing insights into genetic etiology and variant-driven RA pathogenesis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Immunology
Li Xiong, Liang Xiong, Hong Ye, Wan-Li Ma
Summary: This study reviews the current status and future prospects of animal models for rheumatoid arthritis-associated interstitial lung disease (RA-ILD), emphasizing the importance of these models in investigating the pathogenesis and developing therapeutic drugs. The discussion highlights the valuable information provided by animal models, while also pointing out their limitations in replicating clinical pathology and the need for improvement to better align with the characteristics of human RA-ILD.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Pharmacology & Pharmacy
Julie Kessler, Perle Totoson, Sylvie Devaux, Johnny Moretto, Daniel Wendling, Celine Demougeot
Summary: Research on animal models of rheumatoid arthritis can help understand the complex link between arthritis and the heart, and identify new therapeutic targets. This review presents data on cardiac disorders in animal models of RA, as well as current knowledge on the pathophysiology and pharmacology of these disorders. Future directions for translational studies in a cardiorheumatic perspective are proposed.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Stefano Ministrini, Federico Carbone
Summary: There is a clear link between autoimmune disease and cardiovascular risk, but the underlying mechanisms are complex and not well understood. PCSK9 is gaining attention as a potential mediator due to its effects on lipid metabolism and inflammation. However, the role of PCSK9 in autoimmune diseases is uncertain, and clinical findings are conflicting.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Rheumatology
Eleftheria Pertsinidou, Saedis Saevarsdottir, Vivek Anand Manivel, Lars Klareskog, Lars Alfredsson, Linda Mathsson-Alm, Monika Hansson, Martin Cornillet, Guy Serre, Rikard Holmdahl, Karl Skriner, Per-Johan Jakobsson, Helga Westerlind, Johan Askling, Johan Roennelid
Summary: In early RA patients, ACPA is associated with a lower number of affected joints, while RF is associated with elevated systemic inflammation markers in an ACPA-dependent manner. This finding supports the in vitro models of ACPA and RF in immune complex-induced inflammation. These phenotypic associations are independent of classification criteria.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Anqi Li, Zhanfeng Zhang, Xiaochen Ru, Yanfeng Yi, Xiaoyu Li, Jing Qian, Jue Wang, Xiaobing Yang, Yunliang Yao
Summary: Through gene expression analysis, a total of 1,885 up-regulated and 1,899 down-regulated DEGs were identified in RA samples. The analysis showed significant differences in the infiltration of 25 cells, and 603 immune-related genes were obtained through WGCNA, with 270 DEIRGs identified. Enrichment analysis indicated that DEIRGs were associated with immunity-related biological processes, and 4 candidate biomarkers were identified through the PPI network.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Eunji Ha, So-Young Bang, Jiwoo Lim, Jun Ho Yun, Jeong-Min Kim, Jae-Bum Bae, Hye-Soon Lee, Bong-Jo Kim, Kwangwoo Kim, Sang-Cheol Bae
Summary: The study identified a large number of rheumatoid arthritis-specific DEGs in CD4(+) T cells, with a focus on T cell differentiation and activation pathways. Additionally, rheumatoid arthritis-specific DMRs were correlated with the expression levels of DEGs, mainly in the same topologically associating domains. Furthermore, expressional variances in DEGs were partially explained by expression QTLs and meQTLs, indicating potential regulatory roles of rheumatoid arthritis-risk variants in shaping gene expression and methylation patterns.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Materials Science, Biomaterials
Ajay Kumar, Aneesh Ali, Akshay Kanika, Akshay Vyawahare, Anas Ahmad, Rakesh Kumar Mishra, Md Meraj Ansari, Ahmed Nadeem, Nahid Siddiqui, Syed Shadab Raza, Rehan Khan
Summary: Rheumatoid arthritis is a chronic inflammatory disease that severely affects joints and restricts locomotion. The pathophysiology of the disease involves cytokines, immune responses, genetic dispositions, viral infections, and toxicants. Various treatment regimens are available for short-term relief, but long-term relief is still not achieved.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Medicinal
Sebastian Makuch, Kamil Wiecek, Marta Wozniak
Summary: Rheumatoid arthritis is a chronic autoimmune disorder that affects joints, leading to irreversible tissue degeneration and inflammation. Curcumin, a natural compound with anti-inflammatory properties, shows potential in modulating inflammatory responses and could play a role in the treatment of rheumatoid arthritis.
Article
Rheumatology
Liam J. O'Neil, Christopher B. Oliveira, Xinghao Wang, Mario Navarrete, Ana Barrera-Vargas, Javier Merayo-Chalico, Rwan Aljahdali, Eduardo Aguirre-Aguilar, Philip Carlucci, Mariana J. Kaplan, Carmelo Carmona-Rivera
Summary: Neutrophil infiltration into the synovial joint is a hallmark of rheumatoid arthritis (RA). This study found that carbamylation, a posttranslational modification, is linked to increased bone erosion in RA. The researchers demonstrated that neutrophil extracellular traps (NETs) and their carbamylated protein cargo directly promote bone destruction by inducing osteoclast formation.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Kevin L. Winthrop, Peter Nash, Kunihiro Yamaoka, Eduardo Mysler, Nasser Khan, Heidi S. Camp, Yanna Song, Jessica L. Suboticki, Jeffrey R. Curtis
Summary: In patients with RA, treatment with Upadacitinib (UPA) was associated with higher incidence and event rates of herpes zoster (HZ) compared to treatment with methotrexate (MTX) monotherapy or adalimumab (ADA) + MTX. The risk of HZ was also higher with the 30 mg dose of UPA compared to the 15 mg dose. Patients from Asia and those with a history of HZ may have an increased risk of HZ while receiving UPA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
James I. Robinson, Md Yuzaiful Md Yusof, Vinny Davies, Dawn Wild, Michael Morgan, John C. Taylor, Yasser El-Sherbiny, David L. Morris, Lu Liu, Andy C. Rawstron, Maya H. Buch, Darren Plant, Heather J. Cordell, John D. Isaacs, Ian N. Bruce, Paul Emery, Anne Barton, Timothy J. Vyse, Jennifer H. Barrett, Edward M. Vital, Ann W. Morgan, MATURA Consortia, MASTERPLANS Consortia
Summary: This study evaluated the impact of FCGR variants on clinical response and immune cell function in rituximab therapy. The study found that FCGR3A-158V variant and increased copy numbers were associated with better clinical response in rheumatoid arthritis patients. In systemic lupus erythematosus patients, FCGR3A-158V variant and FCGR2C-ORF copy numbers were associated with better clinical response. Furthermore, NK cell Fc gamma RIIIa expression and ADCC were associated with clinical response and B-cell depletion.
Article
Immunology
Tian-Ping Zhang, Rui Li, Hong-Miao Li, Nan Xiang, Zhen Tan, Guo-Sheng Wang, Xiao-Mei Li
Summary: The study found that polymorphisms in ARNT rs11204735, AHRR rs2292596, and rs2672725 were associated with susceptibility to rheumatoid arthritis (RA), while AHR gene polymorphisms showed no significant association with RA susceptibility. Additionally, altered methylation levels of AHR and AHRR genes were related to the risk of RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Tushar Baviskar, Dezaree Raut, Lokesh Kumar Bhatt
Summary: COVID-19, caused by SARS-CoV-2, has impacted over 200 nations globally. Efforts are being made worldwide to develop vaccines to combat the rapid transmission of this virus.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Neurosciences
Paresh Patel, Kalyani Barve, Lokesh Kumar Bhatt
Summary: The study demonstrates the protective effect of Narirutin-rich fraction (NRF) against cerebral ischemia/reperfusion injury in rats. NRF pretreatment improves neurobehavioral alterations and histological findings and reduces oxidative damage.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Tushar Baviskar, Munira Momin, Jingwen Liu, Bin Guo, Lokesh Bhatt
Summary: Colorectal carcinogenesis is a complex process involving genetic alterations, genetic and epigenetic modulations, chromosomal abnormalities, and mutations in oncogenes and tumor suppressor genes. Genes such as KRAS, BRAF, PI3KCA, and TP53 play significant roles at different stages of colorectal cancer.
CURRENT DRUG TARGETS
(2021)
Review
Peripheral Vascular Disease
Lokesh Kumar Bhatt, Ishant Selokar, Dezaree Raut, Tahir Hussain
Summary: This review discusses emerging pharmacological therapies for hypertension, including potential targets such as Toll-like receptor 4, protease-activated receptor 2, and chemerin.
CURRENT HYPERTENSION REPORTS
(2021)
Review
Infectious Diseases
Shreya R. Savla, Kedar S. Prabhavalkar, Lokesh K. Bhatt
Summary: SARS-CoV-2 infection triggers cytokine storm and coagulation abnormalities. Prophylactic LMWH therapy is recommended for hospitalized patients to prevent VTE, while treatment dose of LMWH is being considered for patients with significantly elevated levels of D-dimer. Targeting coagulation and inflammation-related molecules may help reduce lung injury, microvascular thrombosis, VTE, and other outcomes associated with SARS-CoV-2 infection.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Review
Endocrinology & Metabolism
Priti Ramakant Gupta, Kedar Prabhavalkar
Summary: Anxiety, characterized by excessive worry, is currently treated with therapies that have disadvantages. Innovative approaches are needed to overcome these disadvantages. Recent findings suggest a correlation of glutamate with anxiety, offering potential for new drug development.
Article
Pharmacology & Pharmacy
Mohsina Shaikh, Neha Desai, Munira Momin, Lokesh Kumar Bhatt
Summary: The study successfully developed a microflora-triggered colon targeted sustained-release dosage form using Gum Ghatti and Hydroxypropyl Methylcellulose, with in vitro and ex vivo dissolution profiles demonstrating high drug release rates. The formulation was stable under standard ICH stability study conditions, showing potential for various drug categories.
CURRENT DRUG DELIVERY
(2021)
Review
Oncology
Dezaree Raut, Amisha Vora, Lokesh Kumar Bhatt
Summary: In vitro and in vivo studies suggest that targeting the Wnt signaling pathway has great potential in the prevention and management of breast cancer. However, more clinical studies are needed to support their use in humans. Besides agents already in clinical trials, a number of drug combinations discussed may see clinical application in the near future.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Review
Immunology
Niraj Parihar, Lokesh Kumar Bhatt
Summary: The ubiquitin-proteasome pathway plays a crucial role in the development of autoimmune diseases, with DUBs regulating protein ubiquitination to influence immune responses.
INFLAMMOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shivani Gokani, Lokesh Kumar Bhatt
Summary: Caveolin-1 is a key protein localized in caveolae of the plasma membrane of eukaryotic cells, involved in regulating cellular signaling and various disease processes. Its role in neurodegeneration, cognitive decline, aging, and tumorigenesis has been studied, although the exact mechanisms are still unclear.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kripa Jain, Kalyani Barve, Lokesh Kumar Bhatt
Summary: This review summarizes the physiological roles and signal transduction of gasdermins and highlights their significance in pathological conditions such as autoimmune diseases, kidney diseases, and central nervous system diseases.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Review
Endocrinology & Metabolism
Rhema Chandan Khairnar, Niraj Parihar, Kedar S. Prabhavalkar, Lokesh Kumar Bhatt
Summary: Parkinson's disease patients experience both motor and non-motor symptoms. Current pharmacological treatments only provide temporary relief and are unable to restore neural function or halt disease progression. Therefore, there is a need for disease-modifying treatments for PD.
METABOLIC BRAIN DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Faiza Shaikh, Lokesh Kumar Bhatt
Summary: The combination of Dantrolene and Polymyxin-B provides cardioprotective action against hypertrophic cardiomyopathy by attenuating CaMKII, preventing myocardial damage and improving cardiac function.
CHEMISTRY & BIODIVERSITY
(2022)
Review
Pharmacology & Pharmacy
Shreya R. Savla, Kedar S. Prabhavalkar, Lokesh K. Bhatt
Summary: LXRs are important regulators of atherosclerosis and understanding their role is important for developing potential therapeutics. This review discusses the role of LXRs in atherosclerotic development, LXR agonists, and future research directions. It highlights the need for further research on specific agonist-targeted LXR isoforms and cell type-specific knockout models.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
