Noninvasive Molecular Imaging of Neuroinflammation

Quantitative Preclinical Imaging of TSPO Expression in Glioma Using N,N-Diethyl-2-(2-(4-(2-18F-Fluoroethoxy)Phenyl)-5,7-Dimethylpyrazolo[1,5-a]Pyrimidin-3-yl)Acetamide

(2012) D. Tang et al.   JOURNAL OF NUCLEAR MEDICINE

125I-Labeled Gold Nanorods for Targeted Imaging of Inflammation

(2011) Xia Shao et al.   ACS Nano

PET/CT in diagnosis of dementia

(2011) Valentina Berti et al.   Annals of the New York Academy of Sciences

Fluorinated cannabinoid CB2 receptor ligands: Synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives

(2011) Nashaat Turkman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Brain inflammation is induced by co-morbidities and risk factors for stroke

(2011) Caroline Drake et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke

(2011) David Brea et al.   CLINICAL IMMUNOLOGY

Microglia Phenotype Diversity

(2011) M. Olah et al.   CNS & Neurological Disorders-Drug Targets

The Yin and Yang of Microglia

(2011) Melinda Czeh et al.   DEVELOPMENTAL NEUROSCIENCE

Imaging of neuroinflammation

(2011) Andrea Ciarmiello   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Evaluation of [123I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation

(2011) Filomena Mattner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Adapted focal experimental autoimmune encephalomyelitis to allow MRI exploration of multiple sclerosis features

(2011) Thomas Tourdias et al.   EXPERIMENTAL NEUROLOGY

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

In Vivo Analysis of Uropod Function during Physiological T Cell Trafficking

(2011) S. F. Soriano et al.   JOURNAL OF IMMUNOLOGY

Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis

(2011) T. Hayton et al.   JOURNAL OF NEUROLOGY

A PET Brain Reporter Gene System Based on Type 2 Cannabinoid Receptors

(2011) C. Vandeputte et al.   JOURNAL OF NUCLEAR MEDICINE

In Vivo Expression of Cyclooxygenase-1 in Activated Microglia and Macrophages During Neuroinflammation Visualized by PET with 11C-Ketoprofen Methyl Ester

(2011) M. Shukuri et al.   JOURNAL OF NUCLEAR MEDICINE

Circulating CD133+CD34+ progenitor cells inversely correlate with soluble ICAM-1 in early ischemic stroke patients

(2011) Tanya Bogoslovsky et al.   Journal of Translational Medicine

Stroke and the immune system: from pathophysiology to new therapeutic strategies

(2011) Richard Macrez et al.   LANCET NEUROLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS

(2011) Payam Dibaj et al.   PLoS One

Detection and monitoring of the multiple inflammatory responses by photoacoustic molecular imaging using selectively targeted gold nanorods

(2011) Seunghan Ha et al.   Biomedical Optics Express

Radiosynthesis of [18F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins

(2010) Pradip Ghosh et al.   APPLIED RADIATION AND ISOTOPES

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

(2010) Andrew G. Horti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer’s disease

(2010) Ahmadul Kadir et al.   BRAIN

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Microglia dynamics and function in the CNS

(2010) Christopher N Parkhurst et al.   CURRENT OPINION IN NEUROBIOLOGY

New approaches to neuroimaging of central nervous system inflammation

(2010) Guido Stoll et al.   CURRENT OPINION IN NEUROLOGY

Positron emission tomography imaging in multiple sclerosis-current status and future applications

(2010) L. Kiferle et al.   EUROPEAN JOURNAL OF NEUROLOGY

In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa)

(2010) Fabien Chauveau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo imaging of neuroinflammation: a comparative study between [18F]PBR111, [11C]CLINME and [11C]PK11195 in an acute rodent model

(2010) Nadja Van Camp et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease

(2010) Masamichi Yokokura et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice

(2010) A. Florence Keller et al.   EXPERIMENTAL NEUROLOGY

Superior sensitivity of novel molecular imaging probe: simultaneously targeting two types of endothelial injury markers

(2010) Dawei Sun et al.   FASEB JOURNAL

Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome

(2010) Shintaro Iwama et al.   GLIA

Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state

(2010) Judy Choi et al.   GLIA

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

In Vivo Volumetric Intravascular Ultrasound Visualization of Early/Inflammatory Arterial Atheroma Using Targeted Echogenic Immunoliposomes

(2010) Hyunggun Kim et al.   INVESTIGATIVE RADIOLOGY

Molecular Magnetic Resonance Imaging of Acute Vascular Cell Adhesion Molecule-1 Expression in a Mouse Model of Cerebral Ischemia

(2010) Lisa C Hoyte et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands

(2010) D. R. J. Owen et al.   JOURNAL OF NUCLEAR MEDICINE

The Temporal Dynamics of Poststroke Neuroinflammation: A Longitudinal Diffusion Tensor Imaging-Guided PET Study with 11C-PK11195 in Acute Subcortical Stroke

(2010) A. Thiel et al.   JOURNAL OF NUCLEAR MEDICINE

Quantitative, Preclinical PET of Translocator Protein Expression in Glioma Using 18F-N-Fluoroacetyl-N-(2,5-Dimethoxybenzyl)-2-Phenoxyaniline

(2010) J. R. Buck et al.   JOURNAL OF NUCLEAR MEDICINE

Advanced MRI and PET imaging for assessment of treatment response in patients with gliomas

(2010) Frederic G Dhermain et al.   LANCET NEUROLOGY

Reduced PBR/TSPO Expression After Minocycline Treatment in a Rat Model of Focal Cerebral Ischemia: A PET Study Using [18F]DPA-714

(2010) Abraham Martín et al.   MOLECULAR IMAGING AND BIOLOGY

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-l-deprenyl using whole hemisphere autoradiography

(2010) Balázs Gulyás et al.   NEUROCHEMISTRY INTERNATIONAL

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

The time window of MRI of murine atherosclerotic plaques after administration of CB2 receptor targeted micelles: inter-scan variability and relation between plaque signal intensity increase and gadolinium content of inversion recovery prepared versus non-

(2010) B. C. M. te Boekhorst et al.   NMR IN BIOMEDICINE

Calpain 2 Controls Turnover of LFA-1 Adhesions on Migrating T Lymphocytes

(2010) Lena Svensson et al.   PLoS One

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Knocking at the brain’s door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures

(2010) Naoto Kawakami et al.   Seminars in Immunopathology

Intracellular Nanoparticle Coating Stability Determines Nanoparticle Diagnostics Efficacy and Cell Functionality

(2010) Stefaan J. H. Soenen et al.   Small

Minocycline to Improve Neurologic Outcome in Stroke (MINOS)

(2010) Susan C. Fagan et al.   STROKE

A Simple Positron Emission Tomography-Based Calibration for Perfusion-Weighted Magnetic Resonance Maps to Optimize Penumbral Flow Detection in Acute Stroke

(2010) Olivier Zaro-Weber et al.   STROKE

Multimodal microglia imaging of fiber tracts in acute subcortical stroke

(2009) Basia A. Radlinska et al.   ANNALS OF NEUROLOGY

Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody

(2009) Fatih Arslan et al.   CIRCULATION

Functional and Molecular Ultrasound Imaging: Concepts and Contrast Agents

(2009) F. Kiessling et al.   CURRENT MEDICINAL CHEMISTRY

Radiolabelled Molecules for Imaging the Translocator Protein (18 kDa) Using Positron Emission Tomography

(2009) Frederic Dolle et al.   CURRENT MEDICINAL CHEMISTRY

Spatial diversity of blood–brain barrier alteration and macrophage invasion in experimental autoimmune encephalomyelitis: A comparative MRI study

(2009) Gesa Ladewig et al.   EXPERIMENTAL NEUROLOGY

Evaluation of the PBR/TSPO Radioligand [18F]DPA-714 in a Rat Model of Focal Cerebral Ischemia

(2009) Abraham Martín et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammation Extends Brain Tissue at Risk to Vital Peri-Infarct Tissue: A Double Tracer [11C]PK11195- and [18F]FDG-PET Study

(2009) Michael Schroeter et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites

(2009) Jiyun V. Kim et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways

(2009) Chih-Liang Chin et al.   JOURNAL OF NEUROIMMUNOLOGY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Radioisotopic Imaging of Neuroinflammation

(2009) A. Winkeler et al.   JOURNAL OF NUCLEAR MEDICINE

11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression

(2009) Y. Cui et al.   JOURNAL OF NUCLEAR MEDICINE

Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation

(2009) F. Chauveau et al.   JOURNAL OF NUCLEAR MEDICINE

Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study

(2009) J. Doorduin et al.   JOURNAL OF NUCLEAR MEDICINE

Imipramine, in Part through Tumor Necrosis Factor   Inhibition, Prevents Cognitive Decline and  -Amyloid Accumulation in a Mouse Model of Alzheimer's Disease

(2009) F. Chavant et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Methods to monitor gene therapy with molecular imaging

(2009) Yannic Waerzeggers et al.   METHODS

[11C]-DPA-713 and [18F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [11C]-(R)-PK11195 in a Rat Model of Herpes Encephalitis

(2009) Janine Doorduin et al.   MOLECULAR IMAGING AND BIOLOGY

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Minocycline 1-year therapy in multiple-system-atrophy: Effect on clinical symptoms and [11C](R)-PK11195 PET (MEMSA-trial)

(2009) Richard Dodel et al.   MOVEMENT DISORDERS

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

T time in the brain

(2009) Eng H Lo   NATURE MEDICINE

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Imaging outcomes for neuroprotection and repair in multiple sclerosis trials

(2009) Frederik Barkhof et al.   Nature Reviews Neurology

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

(2009) V. Wee Yong et al.   NEURON

Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging

(2009) Nele Evens et al.   NUCLEAR MEDICINE AND BIOLOGY

Evaluation of [11C]-DAA1106 for imaging and quantification of neuroinflammation in a rat model of herpes encephalitis

(2009) Janine Doorduin et al.   NUCLEAR MEDICINE AND BIOLOGY

[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

(2009) A.L. Bartels et al.   PARKINSONISM & RELATED DISORDERS

Microglial Involvement in Neuroplastic Changes Following Focal Brain Ischemia in Rats

(2009) Alexandre Madinier et al.   PLoS One

Image-guided, noninvasive, spatiotemporal control of gene expression

(2009) R. Deckers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Early-Stage Investigations of Ultrasmall Superparamagnetic Iron Oxide-Induced Signal Change After Permanent Middle Cerebral Artery Occlusion in Mice

(2009) Virginie Desestret et al.   STROKE

Neuronal regulation of immune responses in the central nervous system

(2009) Li Tian et al.   TRENDS IN IMMUNOLOGY

Longitudinal in Vivo Positron Emission Tomography Imaging of Infected and Activated Brain Macrophages in a Macaque Model of Human Immunodeficiency Virus Encephalitis Correlates with Central and Peripheral Markers of Encephalitis and Areas of Synaptic Degeneration

(2008) Sriram Venneti et al.   AMERICAN JOURNAL OF PATHOLOGY

Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement

(2008) Machteld M. Vellinga et al.   BRAIN

Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis

(2008) J. W. Chen et al.   BRAIN

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation

(2008) Nicolas Arlicot et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

(2008) Fabien Chauveau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease

(2008) Jian Luo et al.   Journal of Neuroinflammation

Novel Reference Region Model Reveals Increased Microglial and Reduced Vascular Binding of 11C-(R)-PK11195 in Patients with Alzheimer's Disease

(2008) G. Tomasi et al.   JOURNAL OF NUCLEAR MEDICINE

DPA-714, a New Translocator Protein-Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic Characterization

(2008) M. L. James et al.   JOURNAL OF NUCLEAR MEDICINE

MRI in multiple sclerosis: current status and future prospects

(2008) Rohit Bakshi et al.   LANCET NEUROLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET

(2008) Sriram Venneti et al.   NEUROBIOLOGY OF AGING

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Non-invasive visualization of CNS inflammation with nuclear and optical imaging

(2008) A. Wunder et al.   NEUROSCIENCE

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase

(2008) M. O. Breckwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live Imaging of Neuroinflammation Reveals Sex and Estrogen Effects on Astrocyte Response to Ischemic Injury

(2008) Pierre Cordeau et al.   STROKE

Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: Preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients

(2007) Ádám Vas et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: Implications for PET imaging of neuroinflammation in lentiviral encephalitis

(2007) Sriram Venneti et al.   NEUROBIOLOGY OF DISEASE

Evaluation of [11C]rofecoxib as PET tracer for cyclooxygenase 2 overexpression in rat models of inflammation

(2007) Erik F.J. de Vries et al.   NUCLEAR MEDICINE AND BIOLOGY