Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

Molecular discrimination of responders and nonresponders to anti-TNFalpha therapy in rheumatoid arthritis by etanercept

(2012) Dirk Koczan et al.   ARTHRITIS RESEARCH & THERAPY

Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)

(2011) Ian McGowan et al.   AIDS

Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis

(2011) M. H. Buch et al.   ANNALS OF THE RHEUMATIC DISEASES

The anti-CD20 antibody rituximab reduces the Th17 cell response

(2011) Frank L. van de Veerdonk et al.   ARTHRITIS AND RHEUMATISM

Anti-TNF therapy

(2011) Nishanthi Thalayasingam et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Cardiovascular risk factors in inflammatory arthritis

(2011) Hoda Mirjafari et al.   CURRENT OPINION IN LIPIDOLOGY

New therapies in the management of rheumatoid arthritis

(2011) Maya H Buch et al.   CURRENT OPINION IN RHEUMATOLOGY

Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo

(2011) Keisuke Kimura et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation

(2011) Jason C Lenzo et al.   IMMUNOLOGY AND CELL BIOLOGY

Anionic polymers for decreased toxicity and enhanced in vivo delivery of siRNA complexed with cationic liposomes

(2011) Anne Schlegel et al.   JOURNAL OF CONTROLLED RELEASE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis

(2011) D. Pascual-Salcedo et al.   RHEUMATOLOGY

A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis

(2011) M. Hayder et al.   Science Translational Medicine

Anti-Inflammatory Properties of Dendrimersper se

(2011) Myriam Hayder et al.   TheScientificWorldJOURNAL

Macrophage Polarization in Health and Disease

(2011) Luca Cassetta et al.   TheScientificWorldJOURNAL

State-of-the-art: rheumatoid arthritis

(2010) I. B. McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Cytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis

(2010) G. Courties et al.   ARTHRITIS AND RHEUMATISM

Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models

(2010) Shuntaro Hara et al.   BIOCHIMIE

In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells

(2010) G. Courties et al.   BLOOD

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

(2010) Anupa R. Menjoge et al.   DRUG DISCOVERY TODAY

Traditional cardiovascular risk factors in rheumatoid arthritis: A meta-analysis

(2010) Jean-Frédéric Boyer et al.   JOINT BONE SPINE

Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells

(2010) F. S. Kleijwegt et al.   JOURNAL OF IMMUNOLOGY

Anti-TNF Therapy, from Rationale to Standard of Care: What Lessons Has It Taught Us?

(2010) M. Feldmann et al.   JOURNAL OF IMMUNOLOGY

Averting inflammation by targeting the cytokine environment

(2010) Manfred Kopf et al.   NATURE REVIEWS DRUG DISCOVERY

The Gene Expression Profile in the Synovium as a Predictor of the Clinical Response to Infliximab Treatment in Rheumatoid Arthritis

(2010) Johan Lindberg et al.   PLoS One

Structure Activity Relationship of Dendrimer Microbicides with Dual Action Antiviral Activity

(2010) David Tyssen et al.   PLoS One

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis

(2010) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane TNF- : structure, function and interaction with anti-TNF agents

(2010) T. Horiuchi et al.   RHEUMATOLOGY

c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis

(2010) Ricardo T Paniagua et al.   ARTHRITIS RESEARCH & THERAPY

Outside-to-inside signaling through transmembrane tumor necrosis factor reverses pathologic interleukin-1β production and deficient apoptosis of rheumatoid arthritis monocytes

(2009) Undine Meusch et al.   ARTHRITIS AND RHEUMATISM

How to make siRNA lipoplexes efficient? Add a DNA cargo

(2009) Hervé Rhinn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antibodies to citrullinated proteins: molecular interactions and arthritogenicity

(2009) Hüseyin Uysal et al.   IMMUNOLOGICAL REVIEWS

Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model

(2009) Nobuyuki Tai et al.   INFLAMMATION RESEARCH

Rheumatoid arthritis market

(2009) Jeffrey G. Stoll et al.   NATURE REVIEWS DRUG DISCOVERY

Osteoimmunology and the effects of the immune system on bone

(2009) Hiroshi Takayanagi   Nature Reviews Rheumatology

Monocyte Scintigraphy in Rheumatoid Arthritis: The Dynamics of Monocyte Migration in Immune-Mediated Inflammatory Disease

(2009) Rogier M. Thurlings et al.   PLoS One

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

(2009) H. G. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis

(2009) Denis Mulleman et al.   ARTHRITIS RESEARCH & THERAPY

The dynamic interplay between osteoclasts and the immune system

(2008) Tomoki Nakashima et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanisms for cytotoxic effects of anti–tumor necrosis factor agents on transmembrane tumor necrosis factor α–expressing cells: Comparison among infliximab, etanercept, and adalimumab

(2008) Hiroki Mitoma et al.   ARTHRITIS AND RHEUMATISM

Cytosolic Phospholipase A2- : A Potential Therapeutic Target for Prostate Cancer

(2008) M. I. Patel et al.   CLINICAL CANCER RESEARCH

Reduction of cPLA2αoverexpression: An efficient anti-inflammatory therapy for collagen-induced arthritis

(2008) Lior Raichel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Protective role of membrane tumour necrosis factor in the host’s resistance to mycobacterial infection

(2008) Nasiema Allie et al.   IMMUNOLOGY

Anti-inflammatory and immunosuppressive activation of human monocytes by a bioactive dendrimer

(2008) Séverine Fruchon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Blockade of cytosolic phospholipase A2α prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses

(2008) S MARUSIC et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of the cFMS Kinase Inhibitor 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in Normal and Arthritic Rats

(2008) J. G. Conway et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-α monoclonal antibody, infliximab

(2008) N. Sekiguchi et al.   RHEUMATOLOGY

Abatacept in the treatment of rheumatoid arthritis

(2008) Maya H Buch et al.   ARTHRITIS RESEARCH & THERAPY

The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model

(2007) Hiroaki Ohno et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark