Methotrexate Normalizes Up-Regulated Folate Pathway Genes in Rheumatoid Arthritis

Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

(2012) Nitzan Gonen et al.   DRUG RESISTANCE UPDATES

Clinical pharmacogenetic model to predict response of MTX monotherapy in patients with established rheumatoid arthritis after DMARD failure

(2012) Jaap Fransen et al.   PHARMACOGENOMICS

Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients

(2012) S A Owen et al.   PHARMACOGENOMICS JOURNAL

Methotrexate increases expression of cell cycle checkpoint genes via JNK activation

(2011) Charles F. Spurlock et al.   ARTHRITIS AND RHEUMATISM

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis

(2011) Thierry Dervieux et al.   Pharmacogenetics and Genomics

Effect of genetic polymorphisms in the folate pathway on methotrexate therapy in rheumatic diseases

(2011) Lisa K Stamp et al.   PHARMACOGENOMICS

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy

(2010) Lisa K. Stamp et al.   ARTHRITIS AND RHEUMATISM

Assessing the human immune system through blood transcriptomics

(2010) Damien Chaussabel et al.   BMC BIOLOGY

Pharmacogenomics of infliximab treatment using peripheral blood cells of patients with rheumatoid arthritis

(2010) L G M van Baarsen et al.   GENES AND IMMUNITY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Red blood cell methotrexate polyglutamates emerge as a function of dosage intensity and route of administration during pulse methotrexate therapy in rheumatoid arthritis

(2010) Thierry Dervieux et al.   RHEUMATOLOGY

Do snapshot statistics fool us in MTX pharmacogenetic studies in arthritis research?

(2010) M. C. F. J. de Rotte et al.   RHEUMATOLOGY

Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

(2009) Joost W. Van Der Heijden et al.   ARTHRITIS AND RHEUMATISM

Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide

(2009) Joost W. van der Heijden et al.   ARTHRITIS AND RHEUMATISM

Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia

(2009) M. Stark et al.   BLOOD

ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer

(2009) Rieneke van de Ven et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Less Radiographic Progression with Adalimumab Plus Methotrexate Versus Methotrexate Monotherapy Across the Spectrum of Clinical Response in Early Rheumatoid Arthritis

(2009) P. EMERY et al.   JOURNAL OF RHEUMATOLOGY

Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis

(2008) Judith M. Dalrymple et al.   ARTHRITIS AND RHEUMATISM

Getting Started in Biological Pathway Construction and Analysis

(2008) Ganesh A Viswanathan et al.   PLoS Computational Biology