Engineered In Vitro Models of Tumor Dormancy and Reactivation

Mechanical Confinement via a PEG/Collagen Interpenetrating Network Inhibits Behavior Characteristic of Malignant Cells in the Triple Negative Breast Cancer Cell Line MDA.MB.231

(2018) Daniel S. Reynolds et al.   Acta Biomaterialia

Does metronomic chemotherapy induce tumor angiogenic dormancy? A review of available preclinical and clinical data

(2018) Gianfranco Natale et al.   CANCER LETTERS

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway

(2018) Li-Yuan Yu-Lee et al.   CANCER RESEARCH

Fibrin Stiffness Mediates Dormancy of Tumor-Repopulating Cells via a Cdc42-Driven Tet2 Epigenetic Program

(2018) Yuying Liu et al.   CANCER RESEARCH

A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures

(2018) Amanda M. Clark et al.   MOLECULAR & CELLULAR PROTEOMICS

Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells

(2018) Siriporn Keeratichamroen et al.   ONCOLOGY REPORTS

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

(2018) Kevin J. Frankowski et al.   Science Translational Medicine

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

(2018) Jordan A. Krall et al.   Science Translational Medicine

A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy

(2018) Shantanu Pradhan et al.   Scientific Reports

Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids

(2018) Annaïck Desmaison et al.   Scientific Reports

The Current Landscape of 3D In Vitro Tumor Models: What Cancer Hallmarks Are Accessible for Drug Discovery?

(2018) Darren Rodenhizer et al.   Advanced Healthcare Materials

The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation

(2018) Amit S. Yadav et al.   Frontiers in Oncology

Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence

(2018) Samir Tivari et al.   Cell Communication and Signaling

IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization

(2018) Zafira Castaño et al.   NATURE CELL BIOLOGY

Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis

(2018) Lei Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2

(2018) Hak Rae Lee et al.   Journal of Biological Engineering

Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy

(2018) D. Brooke Widner et al.   Current Osteoporosis Reports

EMT and Stemness in Tumor Dormancy and Outgrowth: Are They Intertwined Processes?

(2018) Keren Weidenfeld et al.   Frontiers in Oncology

Dormant tumour cells, their niches and the influence of immunity

(2018) Erica T. Goddard et al.   NATURE CELL BIOLOGY

Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells

(2018) Ryan A. Carpenter et al.   Nature Biomedical Engineering

Metastatic Breast Cancer Cells Enter Into Dormant State and Express Cancer Stem Cells Phenotype Under Chronic Hypoxia

(2017) Alessandra Carcereri de Prati et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metabolic shifts in residual breast cancer drive tumor recurrence

(2017) Kristina M. Havas et al.   JOURNAL OF CLINICAL INVESTIGATION

A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties

(2017) A. M. Clark et al.   LAB ON A CHIP

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Tumor cell dormancy

(2017) Roger R. Gomis et al.   Molecular Oncology

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

(2017) Georg Fluegen et al.   NATURE CELL BIOLOGY

A permanent window for the murine lung enables high-resolution imaging of cancer metastasis

(2017) David Entenberg et al.   NATURE METHODS

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms governing metastatic dormancy in breast cancer

(2017) Jürgen Dittmer   SEMINARS IN CANCER BIOLOGY

The role of exosomes in cancer metastasis

(2017) Teresa Bernadette Steinbichler et al.   SEMINARS IN CANCER BIOLOGY

Exosomes: Key mediators of metastasis and pre-metastatic niche formation

(2017) Richard J. Lobb et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies

(2017) Guan-Zhong Qiu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

(2017) Michael P. Plebanek et al.   Nature Communications

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis

(2017) Meng-Ting Chen et al.   Scientific Reports

Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression

(2016) Xiaowan Chen et al.   CANCER BIOLOGY & THERAPY

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

The bone marrow niche in support of breast cancer dormancy

(2016) Nykia D. Walker et al.   CANCER LETTERS

Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow

(2016) Sarah A. Bliss et al.   CANCER RESEARCH

Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity

(2016) Weina Zhao et al.   CANCER RESEARCH

Disseminated tumor cells and dormancy in prostate cancer metastasis

(2016) Emma E van der Toom et al.   CURRENT OPINION IN BIOTECHNOLOGY

PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture

(2016) Shantanu Pradhan et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Versatile roles of extracellular vesicles in cancer

(2016) Nobuyoshi Kosaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells

(2016) Kyle K. Payne et al.   JOURNAL OF LEUKOCYTE BIOLOGY

From competency to dormancy: a 3D model to study cancer cells and drug responsiveness

(2016) Josephine Y. Fang et al.   Journal of Translational Medicine

Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs)

(2016) Thomas J. Bartosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

(2016) Nicholas Syn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

(2016) Michael Ramirez et al.   Nature Communications

Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth

(2016) Keren Weidenfeld et al.   Oncotarget

Targeting dormant micrometastases: rationale, evidence to date and clinical implications

(2016) Robert E. Hurst et al.   Therapeutic Advances in Medical Oncology

The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks

(2015) Jiranuwat Sapudom et al.   BIOMATERIALS

Identification of novel drugs to target dormant micrometastases

(2015) Robert E. Hurst et al.   BMC CANCER

Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment

(2015) Donna M. Sosnoski et al.   CLINICAL & EXPERIMENTAL METASTASIS

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

Suppression of cancer relapse and metastasis by inhibiting cancer stemness

(2015) Youzhi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

(2015) Hilary A. Kenny et al.   Nature Communications

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation

(2015) Samir Tivari et al.   Jove-Journal of Visualized Experiments

Modeling Selective Elimination of Quiescent Cancer Cells from Bone Marrow

(2015) Stephen P. Cavnar et al.   NEOPLASIA

Investigating Breast Cancer Cell Behavior Using Tissue Engineering Scaffolds

(2015) Khadidiatou Guiro et al.   PLoS One

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system

(2014) S E Wheeler et al.   BRITISH JOURNAL OF CANCER

Cancer Cell Dormancy in Novel Mouse Models for Reversible Pancreatic Cancer: A Lingering Challenge in the Development of Targeted Therapies

(2014) Wan-Chi Lin et al.   CANCER RESEARCH

Complex metastatic niches: already a target for therapy?

(2014) Paloma Ordóñez-Morán et al.   CURRENT OPINION IN CELL BIOLOGY

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

(2014) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

Dual-Phase, Surface Tension-Based Fabrication Method for Generation of Tumor Millibeads

(2014) Shantanu Pradhan et al.   LANGMUIR

Stem cell characteristics of dormant cells and cisplatin-induced effects on the stemness of epithelial ovarian cancer cells

(2014) NAN ZHOU et al.   Molecular Medicine Reports

Cocultures of Mesenchymal Stem Cells and Endothelial Cells As Organotypic Models of Prostate Cancer Metastasis

(2014) Mark S. K. Chong et al.   MOLECULAR PHARMACEUTICS

Dormancy of Cancer Cells with Suppression of AKT Activity Contributes to Survival in Chronic Hypoxia

(2014) Hiroko Endo et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

(2013) B. Boyerinas et al.   BLOOD

A Novel Model of Dormancy for Bone Metastatic Breast Cancer Cells

(2013) R. Marlow et al.   CANCER RESEARCH

Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

(2013) Xiang H.-F. Zhang et al.   CELL

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

Modeling Boundary Conditions for Balanced Proliferation in Metastatic Latency

(2013) D. P. Taylor et al.   CLINICAL CANCER RESEARCH

Metastasis Dormancy in Estrogen Receptor-Positive Breast Cancer

(2013) X. H.- F. Zhang et al.   CLINICAL CANCER RESEARCH

Metastasis suppressors in breast cancers: mechanistic insights and clinical potential

(2013) Christopher R. Bohl et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

(2013) M. Cerezo et al.   MOLECULAR CANCER THERAPEUTICS

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Metastasis Awakening: Targeting dormant cancer

(2013) Julio A Aguirre-Ghiso et al.   NATURE MEDICINE

Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling

(2013) G. Ghiaur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laminin alpha 2 enables glioblastoma stem cell growth

(2012) Justin D. Lathia et al.   ANNALS OF NEUROLOGY

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

Increased Asymmetric and Multi-Daughter Cell Division in Mechanically Confined Microenvironments

(2012) Henry Tat Kwong Tse et al.   PLoS One

Estimated number of prevalent cases of metastatic bone disease in the US adult population

(2012) Thomas J. Arneson et al.   Clinical Epidemiology

Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence

(2011) D. Paez et al.   CLINICAL CANCER RESEARCH

ERK1/2 and p38α/β Signaling in Tumor Cell Quiescence: Opportunities to Control Dormant Residual Disease

(2011) Maria Soledad Sosa et al.   CLINICAL CANCER RESEARCH

The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis

(2011) Sivan Izraely et al.   INTERNATIONAL JOURNAL OF CANCER

Overcoming anoikis - pathways to anchorage-independent growth in cancer

(2011) M. C. Guadamillas et al.   JOURNAL OF CELL SCIENCE

miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level

(2011) Shen-meng Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth

(2011) F. M. Yakes et al.   MOLECULAR CANCER THERAPEUTICS

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Controversies in clinical cancer dormancy

(2011) J. W. Uhr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

(2011) Dalit Barkan et al.   Jove-Journal of Visualized Experiments

Molecular mechanisms underlying tumor dormancy

(2010) Nava Almog   CANCER LETTERS

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

Non-Invasive Cell Tracking in Cancer and Cancer Therapy

(2010) Hao Hong et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth

(2010) Dalit Barkan et al.   EUROPEAN JOURNAL OF CANCER

Breast cancer cell dormancy in bone marrow: potential therapeutic targets within the marrow microenvironment

(2010) Pranela Rameshwar   Expert Review of Anticancer Therapy

Early tumor dissemination, but late metastasis: insights into tumor dormancy

(2010) Martin Röcken   JOURNAL OF CLINICAL INVESTIGATION

Epidemiology of Metastatic Brain Tumors

(2010) Benjamin D. Fox et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Cancer Stem Cells and Aneuploid Populations within Developing Tumors Are the Major Determinants of Tumor Dormancy

(2009) A. P. Kusumbe et al.   CANCER RESEARCH

Cross-talk between Tumor and Endothelial Cells Involving the Notch3-Dll4 Interaction Marks Escape from Tumor Dormancy

(2009) Stefano Indraccolo et al.   CANCER RESEARCH

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Metastatic Dormancy Imposed by the Primary Tumor: Does it Exist in Humans?

(2008) Charlotte F. J. M. Peeters et al.   ANNALS OF SURGICAL ONCOLOGY

Tumor-vascular interactions and tumor dormancy 

(2008) GEORGE N. NAUMOV et al.   APMIS

Integrins in breast cancer dormancy 

(2008) STEPHANIE M. PONTIER et al.   APMIS

The role of metastasis suppressor genes in metastatic dormancy 

(2008) CHRISTINE E. HORAK et al.   APMIS

Cancer micrometastasis and tumour dormancy 

(2008) HARRIET WIKMAN et al.   APMIS

Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy 

(2008) ELENA FAVARO et al.   APMIS

Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton

(2008) D. Barkan et al.   CANCER RESEARCH

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

(2008) Zhen Lu et al.   JOURNAL OF CLINICAL INVESTIGATION