Article
Cell Biology
Alejandra I. Ferrer, Ella Einstein, Sara S. Morelli
Summary: Endometrial cancer is a common gynecological cancer, and this article reviews the role of endometrial microenvironment and sex hormone signaling in sustaining and promoting dormancy of endometrial cancer progenitor cells. The perspective focuses on the potential role of bone marrow-derived cells in supporting the survival and dormancy of endometrial cancer stem cells.
Article
Oncology
Robert Wieder
Summary: Breast cancer cells can travel to the bone before being detectable in the breast, and these disseminated cells are resistant to treatment. They can remain dormant for over 20 years before recurring and causing incurable diseases. Various factors can wake up dormant cancer cells, including aging, inflammation, trauma, surgery, and psychological conditions. Efforts have been made to kill or maintain these disseminated cells, with some entering clinical trials.
Review
Biochemistry & Molecular Biology
Marina Ibragimova, Matvey Tsyganov, Nikolai Litviakov
Summary: This review discusses the main mechanisms of CSCs in breast cancer, including markers and signaling pathways, heterogeneity, plasticity, and ecological behavior. The study also considers the significance of dynamic heterogeneity of CSCs and dynamic transitions between CSCs and non-CSCs for metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Antonio Maurizi, Michela Ciocca, Cristiano Giuliani, Ilaria Di Carlo, Anna Teti
Summary: This study identified the role of N-Cadherin in breast cancer cell dormancy and stemness. Breast cancer cells that interact with spindle-shaped N-Cadherin(+) Osteoblasts (SNOs) become dormant, and N-Cadherin mediates the adhesion of breast cancer cells to SNOs. The study also revealed differences in the role of N-Cadherin between human and mouse breast cancer cell lines.
Article
Biology
Garima Sinha, Alejandra Ferrer, Seda Ayer, Markos H. El-Far, Sri Harika Pamarthi, Yahaira Naaldijk, Pradeep Barak, Oleta A. Sandiford, Bernadette M. Bibber, Ghassan Yehia, Steven J. Greco, Jie-Gen Jiang, Margarette Bryan, Rakesh Kumar, Nicholas M. Ponzio, Jean-Pierre Etchegaray, Pranela Rameshwar
Summary: The challenge in treating breast cancer lies partly in the long-term dormancy driven by cancer stem cells (CSCs) that can evade the immune response and resist chemotherapy. The use of connexin 43 (Cx43) by CSCs to communicate within the bone marrow niche is a key factor in maintaining dormancy. However, N-cadherin (CDH2) and its associated pathways have been identified as potential drug targets, as they are highly expressed in CSCs and are involved in maintaining dormancy and communication in the bone marrow niche. These pathways could serve as pharmacological targets to prevent dormancy and sensitize CSCs that are resistant to chemotherapy.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemical Research Methods
Martina Crippa, Simone Bersini, Mara Gilardi, Chiara Arrigoni, Sara Gamba, Anna Falanga, Christian Candrian, Gabriele Dubini, Marco Vanoni, Matteo Moretti
Summary: The presence of platelets and neutrophils in the early metastatic niche significantly enhances cancer cell transendothelial migration. Using an antiplatelet drug can reduce the expression of EMT markers in cancer cells and impair their ability to extravasate, providing new insights for clinical treatment.
Review
Cell Biology
Xiaofan Jiang, Lu Liang, Guanglei Chen, Caigang Liu
Summary: Cancer stem cells (CSCs) and dormant cancer cells play significant roles in tumor progression and treatment, but the precise relationship between them is still unclear. Understanding how immune components interact with CSCs and dormant cancer cells is essential for preventing cancer relapse and metastasis.
Article
Cell Biology
Igor L. Bado, Weijie Zhang, Jingyuan Hu, Zhan Xu, Hai Wang, Poonam Sarkar, Lucian Li, Ying-Wooi Wan, Jun Liu, William Wu, Hin Ching Lo, Ik Sun Kim, Swarnima Singh, Mahnaz Janghorban, Aaron M. Muscarella, Amit Goldstein, Purba Singh, Hyun-Hwan Jeong, Chaozhong Liu, Rachel Schiff, Shixia Huang, Matthew J. Ellis, M. Waleed Gaber, Zbigniew Gugala, Zhandong Liu, Xiang H-F Zhang
Summary: Estrogen receptor-positive (ER+) breast cancer shows strong bone tropism in metastasis, with the bone microenvironment impacting ER signaling and endocrine therapy. The osteogenic niche transiently reduces ER expression and activities specifically in bone micrometastases, leading to endocrine resistance. EZH2-mediated epigenomic reprogramming drives ER+ BMMs towards a basal and stem-like state, and EZH2 inhibition reverses endocrine resistance.
DEVELOPMENTAL CELL
(2021)
Article
Cell Biology
George R. Nahas, Lauren S. Sherman, Garima Sinha, Markos H. El Far, Andrew Petryna, Steven M. Munoz, Kimberly A. Silverio, Maran Shaker, Pujan Neopane, Veronica Mariotti, Pranela Rameshwar
Summary: Breast cancer stem cells can resist treatment and exist as dormant cells in tissues. The RNA-binding protein Msi 1 plays a role in maintaining the existence of breast cancer stem cells and promoting differentiation of breast cancer cells. Msi 1 is also related to the immune checkpoint molecule PD-L1, which has implications for breast cancer therapy and prevention.
Review
Cell Biology
Hongjiang Si, Madelyn Esquivel, Erika Mendoza Mendoza, Kevin Roarty
Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide and is a leading cause of cancer-related deaths. While there have been advancements in treating the primary tumor, systemic treatments to prevent metastasis are still limited. Metastatic disease is the main factor contributing to fatality in breast cancer patients. Understanding the mechanisms driving tumor cell growth, survival, and spread, as well as their interaction with the microenvironment, is crucial for identifying potential therapeutic interventions for metastasis and cancer dormancy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi, Hongxi Xu
Summary: Bone metastasis occurs when tumor cells enter the circulation and colonize sites in the bone. Dormant tumor cells in the bone marrow are regulated by osteoclasts and osteoblasts. Understanding the roles of these cells in tumor dormancy can provide new insights for preventing and treating bone metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Ryann E. Shor, Jinxiang Dai, Sun-Young Lee, Laura Pisarsky, Irina Matei, Serena Lucotti, David Lyden, Mina J. Bissell, Cyrus M. Ghajar
Summary: Dormant, disseminated tumor cells (DTCs) are believed to be the root of breast cancer metastases, resistant to chemotherapy due to interactions with the microenvironment via integrin-beta 1. Inhibition of PI3K downstream of integrin-beta 1 sensitizes dormant DTCs to chemotherapy, but targeting PI3K failed to reduce DTC burden or prevent metastasis in preclinical studies. This raises doubts about the strategy to eliminate DTCs and prevent breast cancer metastasis by targeting PI3K.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Wenjie Li, Yiquan Li, Yingli Cui, Shanzhi Li, Yilong Zhu, Chao Shang, Gaojie Song, Zirui Liu, Zhiru Xiu, Jianan Cong, Tingyu Li, Xiao Li, Lili Sun, Ningyi Jin
Summary: The study found that the recombinant adenovirus Ad-VT significantly inhibited the growth of MCF-7-CSC cells and induced apoptosis, demonstrating a strong inhibitory effect in mice and providing a new theoretical basis for the future treatment of breast cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xiaoying Li, Yang Li, Xianqiang Du, Xu Wang, Shu Guan, Yu Cao, Feng Li, Feng Jin
Summary: The study indicates that HES1 promotes the stemness properties of BCSC in TNBC by upregulating Slug. TNBC patients with high levels of HES1 and Slug have worse prognosis. HES1 acts as a novel transcriptional activator for Slug, providing new insights for identifying promising prognostic biomarkers and therapeutic targets in TNBC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Russell Hughes, Xinyue Chen, Natasha Cowley, Penelope D. Ottewell, Rhoda J. Hawkins, Keith D. Hunter, Jamie K. Hobbs, Nicola J. Brown, Ingunn Holen
Summary: Bone metastasis in breast cancer patients is a debilitating and incurable complication that requires further research into cellular and molecular mechanisms, as well as the development of new therapeutic strategies to improve survival rates.
Article
Biochemistry & Molecular Biology
Stephanie M. Pontier, Francois Schweisguth
Review
Immunology
F. -X. Campbell-Valois, Stephanie M. Pontier
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Eugene Kang, Alanna Crouse, Lucie Chevallier, Stephanie M. Pontier, Ashwag Alzahrani, Navoun Silue, Francois-Xavier Campbell-Valois, Xavier Montagutelli, Samantha Gruenheid, Danielle Malo
Review
Anatomy & Morphology
Stephanie M. Pontier, Francois Schweisguth
DEVELOPMENTAL DYNAMICS
(2012)
Article
Biochemistry & Molecular Biology
Stephanie M. Pontier, Yann Percherancier, Segolene Galandrin, Andreas Breit, Celine Gales, Michel Bouvier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Editorial Material
Cell Biology
Stephanie M. Pontier, William J. Muller
JOURNAL OF CELL SCIENCE
(2009)
Article
Biochemistry & Molecular Biology
S. M. Pontier, L. Huck, D. E. White, J. Rayment, V. Sanguin-Gendreau, B. Hennessy, D. Zuo, R. St-Arnaud, G. B. Mills, S. Dedhar, C. J. Marshall, W. J. Muller
Article
Multidisciplinary Sciences
L. Huck, S. M. Pontier, D. M. Zuo, W. J. Muller
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Article
Multidisciplinary Sciences
Lauriane Onfroy, Segolene Galandrin, Stephanie M. Pontier, Marie-Helene Seguelas, Du N'Guyen, Jean-Michel Senard, Celine Gales
SCIENTIFIC REPORTS
(2017)
Letter
Biochemistry & Molecular Biology
Stephanie M. Pontier, Francois Schweisguth
Meeting Abstract
Biochemistry & Molecular Biology
S. Pontier, N. Lahale, R. Ginham, F. Stgelais, H. Bonin, D. J. Bell, H. Flynn, L. E. Trudeau, J. Mcilhinney, J. H. White, M. Bouvier
JOURNAL OF NEUROCHEMISTRY
(2007)
Article
Biochemistry & Molecular Biology
Celine Gales, Joost J. J. Van Durm, Stephane Schaak, Stephanie Pontier, Yann Percherancier, Martin Audet, Herve Paris, Michel Bouvier
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2006)
Article
Biochemistry & Molecular Biology
Stephanie M. Pontier, Nicolas Lahaie, Rachel Ginham, Fannie St-Gelais, Helene Bonin, David J. Bell, Helen Flynn, Louis-Eric Trudeau, Jeffrey McIlhinney, Julia H. White, Michel Bouvier
Article
Biochemical Research Methods
J Perroy, S Pontier, PG Charest, M Aubry, M Bouvier