Soft fibrin gels promote selection and growth of tumorigenic cells

A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity

(2011) Youyun Liang et al.   BIOMATERIALS

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation

(2011) G.L. van Sluis et al.   CANCER LETTERS

Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth

(2011) G. Civenni et al.   CANCER RESEARCH

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases

(2011) Sebastian M. Dieter et al.   Cell Stem Cell

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

(2011) Amit Pathak et al.   Integrative Biology

Integrin  5 1 facilitates cancer cell invasion through enhanced contractile forces

(2011) C. T. Mierke et al.   JOURNAL OF CELL SCIENCE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

In vitro generation of human cells with cancer stem cell properties

(2011) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Melanoma Spheroids Grown Under Neural Crest Cell Conditions Are Highly Plastic Migratory/Invasive Tumor Cells Endowed with Immunomodulator Function

(2011) Kiran Ramgolam et al.   PLoS One

Eradication of melanomas by targeted elimination of a minor subset of tumor cells

(2011) P. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Selective Diffusion Barriers Separate Membrane Compartments

(2010) Andreas Bruckbauer et al.   BIOPHYSICAL JOURNAL

Plasma Fibronectin Promotes Lung Metastasis by Contributions to Fibrin Clots and Tumor Cell Invasion

(2010) Gunjan Malik et al.   CANCER RESEARCH

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

(2010) Farhan Chowdhury et al.   PLoS One

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

(2009) Raivo Uibo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells

(2009) Farhan Chowdhury et al.   NATURE MATERIALS

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

(2009) Jessamine P. Winer et al.   PLoS One

2D and 3D collagen and fibrin biopolymers promote specific ECM and integrin gene expression by vascular smooth muscle cells

(2008) Helen Hong et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

The cancer stem cell hypothesis: in search of definitions, markers and relevance

(2008) Michail Shipitsin et al.   LABORATORY INVESTIGATION

Efficient tumour formation by single human melanoma cells

(2008) Elsa Quintana et al.   NATURE