Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression

Metformin represses androgen-dependent and androgen-independent prostate cancers by targeting androgen receptor

(2015) Yan Wang et al.   PROSTATE

Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells

(2015) Camille Loubière et al.   Oncotarget

Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma

(2014) Ji Ma et al.   BMC CANCER

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Growth factor and signaling pathways and their relevance to prostate cancer therapeutics

(2014) Jocelyn L. Wozney et al.   CANCER AND METASTASIS REVIEWS

Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2014) Silvio E. Inzucchi et al.   DIABETES CARE

Metformin Use and Prostate Cancer Risk

(2014) Mark A. Preston et al.   EUROPEAN UROLOGY

Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo

(2014) HISAAKI MIYOSHI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation

(2014) Lei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells

(2014) B. Dirat et al.   MOLECULAR CANCER THERAPEUTICS

Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1

(2014) Xiao Yang et al.   PLoS One

Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway

(2013) GAO YI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

Effects of Metformin Dose on Cancer Risk Reduction in Patients with Type 2 Diabetes Mellitus: A 6-Year Follow-up Study

(2013) Hsiu-Chen Lin et al.   PHARMACOTHERAPY

Pigment epithelium-derived factor increases in type 2 diabetes after treatment with metformin

(2012) Şafak Akın et al.   CLINICAL ENDOCRINOLOGY

Mortality After Incident Cancer in People With and Without Type 2 Diabetes: Impact of metformin on survival

(2012) C. J. Currie et al.   DIABETES CARE

Positive correlation between PEDF expression levels and macrophage density in the human prostate

(2012) Thomas Nelius et al.   PROSTATE

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

PEDF inhibits IL8 production in prostate cancer cells through PEDF receptor/phospholipase A2 and regulation of NFκB and PPARγ

(2011) Jennifer Hirsch et al.   CYTOKINE

Pigment Epithelium-derived Factor and Its Phosphomimetic Mutant Induce JNK-dependent Apoptosis and p38-mediated Migration Arrest

(2010) Alexander Konson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of PEDF: A multi-functional serpin family protein

(2009) S. Filleur et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE