Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer

Elongator—a tRNA modifying complex that promotes efficient translational decoding

(2018) Marcus J.O. Johansson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cooperativity between different tRNA modifications and their modification pathways

(2018) Mikołaj Sokołowski et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma

(2018) Lingeng Lu et al.   CANCER INVESTIGATION

Structural insights into the function of Elongator

(2018) Udit Dalwadi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine

(2018) Fumiaki Obata et al.   DEVELOPMENTAL CELL

A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming

(2018) Mary McMahon et al.   EMBO JOURNAL

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

(2018) Andre Bento-Abreu et al.   HUMAN MOLECULAR GENETICS

Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT

(2018) Yi Xu et al.   International Journal of Biological Sciences

Novel compound heterozygous DPH1 mutations in a patient with the unique clinical features of airway obstruction and external genital abnormalities

(2018) Junya Nakajima et al.   JOURNAL OF HUMAN GENETICS

A novel homozygous DPH1 mutation causes intellectual disability and unique craniofacial features

(2018) Futoshi Sekiguchi et al.   JOURNAL OF HUMAN GENETICS

Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance

(2018) Simone Pellegrino et al.   JOURNAL OF MOLECULAR BIOLOGY

The Uba4 domain interplay is mediated via a thioester that is critical for tRNA thiolation through Urm1 thiocarboxylation

(2018) Martin Termathe et al.   NUCLEIC ACIDS RESEARCH

Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes

(2018) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease

(2018) Kana Asano et al.   NUCLEIC ACIDS RESEARCH

Monitoring the 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification in eukaryotic tRNAs via the γ-toxin endonuclease

(2018) Jenna M. Lentini et al.   RNA

Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis

(2018) Min Dong et al.   SCIENCE

CO2-sensitive tRNA modification associated with human mitochondrial disease

(2018) Huan Lin et al.   Nature Communications

Elongator and codon bias regulate protein levels in mammalian peripheral neurons

(2018) Joy Goffena et al.   Nature Communications

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease

(2018) Md Fakruddin et al.   Cell Reports

Queuosine‐modified tRNAs confer nutritional control of protein translation

(2018) Francesca Tuorto et al.   EMBO JOURNAL

The Hidden Nature of Protein Translational Control by Diphthamide – the secrets under the leather

(2018) Kayoko Tsuda-Sakurai et al.   JOURNAL OF BIOCHEMISTRY

Codon-specific translation reprogramming promotes resistance to targeted therapy

(2018) Francesca Rapino et al.   NATURE

Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast

(2018) Harmen Hawer et al.   PLoS One

Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

(2018) Marija Kojic et al.   Nature Communications

Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression

(2018) Roland Klassen et al.   Scientific Reports

Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly, Short Stature, and Aggressive Behavior

(2018) Arjan P.M. de Brouwer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A null variant in PUS3 confirms its involvement in intellectual disability and further delineates the associated neurodevelopmental disease

(2018) Hanadi A. Abdelrahman et al.   CLINICAL GENETICS

Unfolded Protein Response Suppression in Yeast by Loss of tRNA Modifications

(2018) Alexander Bruch et al.   Genes

tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy

(2017) Simon Edvardson et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Structural asymmetry in the eukaryotic Elongator complex

(2017) Maria I. Dauden et al.   FEBS LETTERS

Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis

(2017) Min Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly

(2017) Daniela A Braun et al.   NATURE GENETICS

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

Wobble uridine modifications–a reason to live, a reason to die?!

(2017) Raffael Schaffrath et al.   RNA Biology

Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator

(2017) Constance Mehlgarten et al.   Toxins

Lost in Translation: Defects in Transfer RNA Modifications and Neurological Disorders

(2017) Andrea Bednářová et al.   Frontiers in Molecular Neuroscience

ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin

(2016) Ikumi Ohshio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ALKBH1-Mediated tRNA Demethylation Regulates Translation

(2016) Fange Liu et al.   CELL

tRNA methyltransferase homologue geneTRMT10Amutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy

(2016) T. W. Yew et al.   DIABETIC MEDICINE

Architecture of the yeast Elongator complex

(2016) Maria I Dauden et al.   EMBO REPORTS

Molecular architecture of the yeast Elongator complex reveals an unexpected asymmetric subunit arrangement

(2016) Dheva T Setiaputra et al.   EMBO REPORTS

A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition

(2016) Ranad Shaheen et al.   HUMAN GENETICS

Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications

(2016) Konstantin Licht et al.   JOURNAL OF CELL BIOLOGY

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

(2016) Sylvain Delaunay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification

(2016) Zhewang Lin et al.   Nature Chemical Biology

Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi

(2016) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast

(2016) Roland Klassen et al.   NUCLEIC ACIDS RESEARCH

Independent suppression of ribosomal +1 frameshifts by different tRNA anticodon loop modifications

(2016) Roland Klassen et al.   RNA Biology

Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi

(2016) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of breast cancer candidate genes using gene co-expression and protein-protein interaction information

(2016) Zhenyu Yue et al.   Oncotarget

Structural characterization of ribosome recruitment and translocation by type IV IRES

(2016) Jason Murray et al.   eLife

Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

(2016) Priyanka D Abeyrathne et al.   eLife

Homozygous deletion ofTRMT10Aas part of a contiguous gene deletion in a syndrome of failure to thrive, delayed puberty, intellectual disability and diabetes mellitus

(2015) Amnon Zung et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

ELP2is a novel gene implicated in neurodevelopmental disabilities

(2015) Julie S. Cohen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

(2015) Danny D. Nedialkova et al.   CELL

Urm1: an essential regulator of JNK signaling and oxidative stress in Drosophila melanogaster

(2015) B. Khoshnood et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes

(2015) Clement T. Y. Chan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis

(2015) Sophie Laguesse et al.   DEVELOPMENTAL CELL

Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification

(2015) Olga Kolaj-Robin et al.   FEBS Journal

Urmylation and tRNA thiolation functions of ubiquitin-like Uba4·Urm1 systems are conserved from yeast to man

(2015) André Jüdes et al.   FEBS LETTERS

Matching Two Independent Cohorts ValidatesDPH1as a Gene Responsible for Autosomal Recessive Intellectual Disability with Short Stature, Craniofacial, and Ectodermal Anomalies

(2015) Catrina M. Loucks et al.   HUMAN MUTATION

Defects in tRNA Anticodon Loop 2′-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations inFTSJ1

(2015) Michael P. Guy et al.   HUMAN MUTATION

Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

(2015) Homa Ghalei et al.   JOURNAL OF CELL BIOLOGY

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine

(2015) Aurélie Ladang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure

(2015) Juliette Létoquart et al.   NUCLEIC ACIDS RESEARCH

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

(2015) Martin Müller et al.   NUCLEIC ACIDS RESEARCH

The role of wobble uridine modifications in +1 translational frameshifting in eukaryotes

(2015) Hasan Tükenmez et al.   NUCLEIC ACIDS RESEARCH

Dimerization of elongator protein 1 is essential for Elongator complex assembly

(2015) Huisha Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2

(2015) Sebastian Glatt et al.   STRUCTURE

Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast

(2015) Wael Abdel-Fattah et al.   PLoS Genetics

Two-subunit enzymes involved in eukaryotic post-transcriptional tRNA modification

(2015) Michael P Guy et al.   RNA Biology

Elongator, a conserved complex required for wobble uridine modifications in Eukaryotes

(2015) Tony Karlsborn et al.   RNA Biology

Mutations in GTPBP3 Cause a Mitochondrial Translation Defect Associated with Hypertrophic Cardiomyopathy, Lactic Acidosis, and Encephalopathy

(2014) Robert Kopajtich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prokaryotic Ubiquitin-Like Protein Modification

(2014) Julie A. Maupin-Furlow   Annual Review of Microbiology

Familial dysautonomia (FD) patients have reduced levels of the modified wobble nucleoside mcm5s2U in tRNA

(2014) Tony Karlsborn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation

(2014) Peter C. Dedon et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A-to-I editing on tRNAs: Biochemical, biological and evolutionary implications

(2014) Adrian Gabriel Torres et al.   FEBS LETTERS

tRNA modifications regulate translation during cellular stress

(2014) Chen Gu et al.   FEBS LETTERS

Role of OVCA1/DPH1 in craniofacial abnormalities of Miller–Dieker syndrome

(2014) Yi-Ru Yu et al.   HUMAN MOLECULAR GENETICS

TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly

(2014) David Gillis et al.   JOURNAL OF MEDICAL GENETICS

A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of theSaccharomyces cerevisiaeElongator complex

(2014) Rachael Di Santo et al.   MOLECULAR MICROBIOLOGY

The diphthamide modification pathway fromSaccharomyces cerevisiae- revisited

(2014) Raffael Schaffrath et al.   MOLECULAR MICROBIOLOGY

Comparative Analysis of the Conserved Functions of Arabidopsis DRL1 and Yeast KTI12

(2014) Sang Eun Jun et al.   MOLECULES AND CELLS

Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism

(2014) Kiruthika Selvadurai et al.   Nature Chemical Biology

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

An evolutionary approach uncovers a diverse response of tRNA 2-thiolation to elevated temperatures in yeast

(2014) Fiona Alings et al.   RNA

Functional importance of Ψ38and Ψ39in distinct tRNAs, amplified for tRNAGln(UUG)by unexpected temperature sensitivity of the s2U modification in yeast

(2014) Lu Han et al.   RNA

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

(2014) Mayumi Okamoto et al.   PLoS Genetics

Defective i6A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA

(2014) John W. Yarham et al.   PLoS Genetics

Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation

(2013) Sunil Laxman et al.   CELL

Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar

(2013) S. Fahiminiya et al.   CLINICAL GENETICS

A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α

(2013) Ulrike Begley et al.   EMBO Molecular Medicine

Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions

(2013) Sandro Argüelles et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutation inADAT3, encoding adenosine deaminase acting on transfer RNA, causes intellectual disability and strabismus

(2013) Anas M Alazami et al.   JOURNAL OF MEDICAL GENETICS

Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression

(2013) Fu-Jung Lin et al.   PLoS Genetics

The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network

(2013) Shanow Uthman et al.   PLoS Genetics

Modification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs

(2013) Jorge Fernández-Vázquez et al.   PLoS Genetics

Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling

(2013) Boris Zinshteyn et al.   PLoS Genetics

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

(2013) Mariana Igoillo-Esteve et al.   PLoS Genetics

Insights into Diphthamide, Key Diphtheria Toxin Effector

(2013) Wael Abdel-Fattah et al.   Toxins

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability

(2012) Lia Abbasi-Moheb et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Biosynthesis and Function of Posttranscriptional Modifications of Transfer RNAs

(2012) Basma El Yacoubi et al.   Annual Review of Genetics

Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

(2012) Ashish Patil et al.   CELL CYCLE

Dual Role of the Molybdenum Cofactor Biosynthesis Protein MOCS3 in tRNA Thiolation and Molybdenum Cofactor Biosynthesis in Humans

(2012) Mita Mullick Chowdhury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ArabidopsisMolybdopterin Biosynthesis Protein Cnx5 Collaborates with the Ubiquitin-like Protein Urm11 in the Thio-modification of tRNA

(2012) Yumi Nakai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational Modification of Cellular Proteins by a Ubiquitin-like Protein in Bacteria

(2012) Naoki Shigi   JOURNAL OF BIOLOGICAL CHEMISTRY

DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator

(2012) Pierre Close et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole exome sequencing identifies a splicing mutation inNSUN2as a cause of a Dubowitz-like syndrome

(2012) Fernando Jose Martinez et al.   JOURNAL OF MEDICAL GENETICS

The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase

(2012) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

(2012) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

Translational Control of Cell Division by Elongator

(2012) Fanelie Bauer et al.   Cell Reports

The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel

(2011) Dimitry A. Chistiakov et al.   ACTA DIABETOLOGICA

Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers

(2011) Mayumi Okamoto et al.   DNA AND CELL BIOLOGY

Q8IYL2 is a candidate gene for the familial epilepsy syndrome of Partial Epilepsy with Pericentral Spikes (PEPS)

(2011) Guy D. Leschziner et al.   EPILEPSY RESEARCH

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA

(2011) Vibeke Leihne et al.   NUCLEIC ACIDS RESEARCH

Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress: Fig. 1.

(2011) Matthew D. Petroski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier

(2011) Annemarthe G. Van der Veen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongator Complex Influences Telomeric Gene Silencing and DNA Damage Response by Its Role in Wobble Uridine tRNA Modification

(2011) Changchun Chen et al.   PLoS Genetics

Casein kinase 1: Complexity in the family

(2010) Jit Kong Cheong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A dual function for chaperones SSB–RAC and the NAC nascent polypeptide–associated complex on ribosomes

(2010) Ansgar Koplin et al.   JOURNAL OF CELL BIOLOGY

Mechanistic understanding of Pyrococcus horikoshiiDph2, a [4Fe–4S] enzyme required for diphthamidebiosynthesis

(2010) Xuling Zhu et al.   Molecular BioSystems

Elongator function in tRNA wobble uridine modification is conserved between yeast and plants

(2010) Constance Mehlgarten et al.   MOLECULAR MICROBIOLOGY

Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme

(2010) Yang Zhang et al.   NATURE

RNA metabolism and the pathogenesis of motor neuron diseases

(2010) Robin Lemmens et al.   TRENDS IN NEUROSCIENCES

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

Acute Infantile Liver Failure Due to Mutations in the TRMU Gene

(2009) Avraham Zeharia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer

(2009) Michaela Frye et al.   CANCER LETTERS

A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression

(2009) K. Shimada et al.   CANCER RESEARCH

Distinct Subsets of Sit4 Holophosphatases Are Required for Inhibition ofSaccharomyces cerevisiaeGrowth by Rapamycin and Zymocin

(2009) Daniel Jablonowski et al.   EUKARYOTIC CELL

Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4

(2009) Constance Mehlgarten et al.   MOLECULAR MICROBIOLOGY

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

(2009) Sebastian Leidel et al.   NATURE

Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions

(2009) Akiko Noma et al.   NUCLEIC ACIDS RESEARCH

The Sulfurtransferase Activity of Uba4 Presents a Link between Ubiquitin-like Protein Conjugation and Activation of Sulfur Carrier Proteins†

(2008) Jennifer Schmitz et al.   BIOCHEMISTRY

Urm1 at the crossroad of modifications. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Patrick G A Pedrioli et al.   EMBO REPORTS

Variants of the elongator protein 3 ( ELP3 ) gene are associated with motor neuron degeneration

(2008) Claire L. Simpson et al.   HUMAN MOLECULAR GENETICS

TheSaccharomyces cerevisiae60 S Ribosome Biogenesis Factor Tif6p Is Regulated by Hrr25p-mediated Phosphorylation

(2008) Partha Ray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thio-modification of Yeast Cytosolic tRNA Requires a Ubiquitin-related System That Resembles Bacterial Sulfur Transfer Systems

(2008) Yumi Nakai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Role for Human Nfs1 in the Cytoplasm

(2008) Zvonimir Marelja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development

(2008) T. R. Webb et al.   JOURNAL OF CELL SCIENCE

Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System

(2008) M. J. O. Johansson et al.   MOLECULAR AND CELLULAR BIOLOGY

A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11Dph3

(2008) Christian Br et al.   MOLECULAR MICROBIOLOGY

Yeast α-tubulin suppressor Ats1/Kti13 relates to the Elongator complex and interacts with Elongator partner protein Kti11

(2008) René Zabel et al.   MOLECULAR MICROBIOLOGY

tRNA and protein methylase complexes mediate zymocin toxicity in yeast

(2008) Patrick Studte et al.   MOLECULAR MICROBIOLOGY

The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity

(2008) M. Dewez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

(2008) C. D. Schlieker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural history of the E1-like superfamily: Implication for adenylation, sulfur transfer, and ubiquitin conjugation

(2008) A. Maxwell Burroughs et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae

(2008) B. Huang et al.   RNA