Prokaryotic Ubiquitin-Like Protein Modification

Ubiquitin Ligases and Cell Cycle Control

(2013) Leonardo K. Teixeira et al.   Annual Review of Biochemistry

Bacterial Proteasome and PafA, the Pup Ligase, Interact to Form a Modular Protein Tagging and Degradation Machine

(2013) Nadav Forer et al.   BIOCHEMISTRY

Pupylation as a signal for proteasomal degradation in bacteria

(2013) Frank Striebel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Macromolecular juggling by ubiquitylation enzymes

(2013) Sonja Lorenz et al.   BMC BIOLOGY

Structural and biochemical properties of an extreme ‘salt-loving’ proteasome activating nucleotidase from the archaeon Haloferax volcanii

(2013) Laurence Prunetti et al.   EXTREMOPHILES

Allosteric Transitions Direct Protein Tagging by PafA, the Prokaryotic Ubiquitin-like Protein (Pup) Ligase

(2013) Naomi Ofer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Complex between Prokaryotic Ubiquitin-like Protein and Its Ligase PafA

(2013) Jonas Barandun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent Probes Reveal a Minimal Ligase Recognition Motif in the Prokaryotic Ubiquitin-like Protein from Mycobacterium tuberculosis

(2013) Denis Smirnov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets

(2013) Gang Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Archaeal Ubiquitin-like SAMP3 is Isopeptide-linked to Proteins via a UbaA-dependent Mechanism

(2013) Hugo V. Miranda et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

The L-Cysteine Desulfurase NFS1 Is Localized in the Cytosol where it Provides the Sulfur for Molybdenum Cofactor Biosynthesis in Humans

(2013) Zvonimir Marelja et al.   PLoS One

Systematic Analysis and Prediction of Pupylation Sites in Prokaryotic Proteins

(2013) Xiang Chen et al.   PLoS One

Fate of Pup inside the Mycobacterium Proteasome Studied by in-Cell NMR

(2013) Andres Y. Maldonado et al.   PLoS One

Ionic strength-dependent conformations of a ubiquitin-like small archaeal modifier protein (SAMP1) fromHaloferax volcanii

(2013) Kaiqin Ye et al.   PROTEIN SCIENCE

Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA

(2013) Hirofumi Nakagawa et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates

(2013) M. Min et al.   Open Biology

Ubiquitin-Like Proteins

(2012) Annemarthe G. van der Veen et al.   Annual Review of Biochemistry

Cell biology of molybdenum in plants and humans

(2012) Ralf R. Mendel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PupDB: a database of pupylated proteins

(2012) Chun-Wei Tung   BMC BIOINFORMATICS

The pupylation pathway and its role in mycobacteria

(2012) Jonas Barandun et al.   BMC BIOLOGY

Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling

(2012) Adriano Marchese et al.   CELLULAR SIGNALLING

Control of MHC II antigen presentation by ubiquitination

(2012) Jessica M Moffat et al.   CURRENT OPINION IN IMMUNOLOGY

ArabidopsisMolybdopterin Biosynthesis Protein Cnx5 Collaborates with the Ubiquitin-like Protein Urm11 in the Thio-modification of tRNA

(2012) Yumi Nakai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational Modification of Cellular Proteins by a Ubiquitin-like Protein in Bacteria

(2012) Naoki Shigi   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosisProkaryotic Ubiquitin-like Protein-deconjugating Enzyme Is an Unusual Aspartate Amidase

(2012) Kristin E. Burns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Archaeal JAB1/MPN/MOV34 metalloenzyme (HvJAMM1) cleaves ubiquitin-like small archaeal modifier proteins (SAMPs) from protein-conjugates

(2012) Nathaniel L. Hepowit et al.   MOLECULAR MICROBIOLOGY

The Expanding Universe of Ubiquitin and Ubiquitin-Like Modifiers

(2012) R. D. Vierstra   PLANT PHYSIOLOGY

Ubiquitin-like proteins and their roles in archaea

(2012) Julie A. Maupin-Furlow   TRENDS IN MICROBIOLOGY

Structures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathway

(2012) Dennis Özcelik et al.   Nature Communications

Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli

(2011) Francisca A Cerda-Maira et al.   EMBO REPORTS

The natural history of ubiquitin and ubiquitin-related domains

(2011) Alexander Maxwell Burroughs   Frontiers in Bioscience-Landmark

Activity of the Mycobacterial Proteasomal ATPase Mpa Is Reversibly Regulated by Pupylation

(2011) Cyrille L. Delley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Identification of a Novel Protein Involved in Molybdenum Cofactor Biosynthesis inEscherichia coli

(2011) Jan-Ulrik Dahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPS-PUP: computational prediction of pupylation sites in prokaryotic proteins

(2011) Zexian Liu et al.   Molecular BioSystems

Proteome-wide identification of mycobacterial pupylation targets

(2011) Christian Poulsen et al.   Molecular Systems Biology

E1- and ubiquitin-like proteins provide a direct link between protein conjugation and sulfur transfer in archaea

(2011) H. V. Miranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new map to understand deubiquitination: Table 1

(2010) Elijah J. Katz et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation

(2010) Kristin E. Burns et al.   CELLULAR MICROBIOLOGY

Control of the oocyte-to-embryo transition by the ubiquitin–proteolytic system in mouse and C. elegans

(2010) Marie-Hélène Verlhac et al.   CURRENT OPINION IN CELL BIOLOGY

The mycobacterial Mpa–proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus

(2010) Frank Striebel et al.   EMBO JOURNAL

Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway

(2010) Frank Imkamp et al.   EMBO REPORTS

Prokaryotic Ubiquitin-Like Protein Provides a Two-Part Degron to Mycobacterium Proteasome Substrates

(2010) K. E. Burns et al.   JOURNAL OF BACTERIOLOGY

Functional Analysis of Molybdopterin Biosynthesis in Mycobacteria Identifies a Fused Molybdopterin Synthase in Mycobacterium tuberculosis

(2010) M. J. Williams et al.   JOURNAL OF BACTERIOLOGY

Mycobacterial Ubiquitin-like Protein Ligase PafA Follows a Two-step Reaction Pathway with a Phosphorylated Pup Intermediate

(2010) Ethan Guth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure and Activation Mechanism of Ubiquitin-Like Small Archaeal Modifier Proteins

(2010) Namit Ranjan et al.   JOURNAL OF MOLECULAR BIOLOGY

Prokaryotic Ubiquitin-like Protein (Pup) Is Coupled to Substrates via the Side Chain of Its C-Terminal Glutamate

(2010) Markus Sutter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

“Depupylation” of Prokaryotic Ubiquitin-like Protein from Mycobacterial Proteasome Substrates

(2010) Kristin E. Burns et al.   MOLECULAR CELL

Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii

(2010) Matthew A. Humbard et al.   NATURE

Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation

(2010) Tao Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into the evolution of Archaea and eukaryotic protein modifier systems revealed by the genome of a novel archaeal group

(2010) Takuro Nunoura et al.   NUCLEIC ACIDS RESEARCH

Prokayrotic Ubiquitin-Like Protein (Pup) Proteome of Mycobacterium tuberculosis

(2010) Richard A. Festa et al.   PLoS One

The Complete Genome Sequence of Haloferax volcanii DS2, a Model Archaeon

(2010) Amber L. Hartman et al.   PLoS One

SAMPyling proteins in archaea

(2010) K. Heran Darwin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Archaeal Ubiquitin-Like Proteins: Functional Versatility and Putative Ancestral Involvement in tRNA Modification Revealed by Comparative Genomic Analysis

(2010) Kira S. Makarova et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

The Mycobacterium tuberculosis Proteasome Active Site Threonine Is Essential for Persistence Yet Dispensable for Replication and Resistance to Nitric Oxide

(2010) Sheetal Gandotra et al.   PLoS Pathogens

The origin and early evolution of eukaryotes in the light of phylogenomics

(2010) Eugene V Koonin   GENOME BIOLOGY

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein

(2009) Shanhui Liao et al.   BIOCHEMICAL JOURNAL

A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa

(2009) Markus Sutter et al.   FEBS LETTERS

Prokaryotic Ubiquitin-Like Protein Pup Is Intrinsically Disordered

(2009) Xiang Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Deletion ofdopinMycobacterium smegmatisabolishes pupylation of protein substratesin vivo

(2009) Frank Imkamp et al.   MOLECULAR MICROBIOLOGY

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

(2009) Sebastian Leidel et al.   NATURE

Inhibitors selective for mycobacterial versus human proteasomes

(2009) Gang Lin et al.   NATURE

Origin and function of ubiquitin-like proteins

(2009) Mark Hochstrasser   NATURE

Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis

(2009) K. Heran Darwin   NATURE REVIEWS MICROBIOLOGY

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

(2009) Brenda A. Schulman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes

(2009) Frank Striebel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions

(2009) Akiko Noma et al.   NUCLEIC ACIDS RESEARCH

The Sulfurtransferase Activity of Uba4 Presents a Link between Ubiquitin-like Protein Conjugation and Activation of Sulfur Carrier Proteins†

(2008) Jennifer Schmitz et al.   BIOCHEMISTRY

O-Phospho-l-serine and the Thiocarboxylated Sulfur Carrier Protein CysO-COSH Are Substrates for CysM, a Cysteine Synthase fromMycobacterium tuberculosis†

(2008) Seán E. O’Leary et al.   BIOCHEMISTRY

Unraveling the biochemistry and provenance of pupylation: a prokaryotic analog of ubiquitination

(2008) Lakshminarayan M Iyer et al.   Biology Direct

Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors

(2008) Naoki Shigi et al.   EMBO JOURNAL

Thio-modification of Yeast Cytosolic tRNA Requires a Ubiquitin-related System That Resembles Bacterial Sulfur Transfer Systems

(2008) Yumi Nakai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine Synthase (CysM) ofMycobacterium tuberculosisIs anO-Phosphoserine Sulfhydrylase

(2008) Daniel Ågren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasomal Protein Degradation in Mycobacteria Is Dependent upon a Prokaryotic Ubiquitin-like Protein

(2008) Kristin E. Burns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

(2008) Yusuke Sato et al.   NATURE

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

(2008) C. D. Schlieker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae

(2008) B. Huang et al.   RNA

Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis

(2008) M. J. Pearce et al.   SCIENCE