Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease

ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications

(2017) Layla Kawarada et al.   NUCLEIC ACIDS RESEARCH

How RNA modification allows non-conventional decoding in mitochondria

(2016) Katherine E. Sloan et al.   CELL CYCLE

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

(2016) Noga Ron-Harel et al.   Cell Metabolism

Nucleoside modifications in the regulation of gene expression: focus on tRNA

(2016) Markus Duechler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NSUN3 and ABH1 modify the wobble position of mt‐tRNAMetto expand codon recognition in mitochondrial translation

(2016) Sara Haag et al.   EMBO JOURNAL

The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish

(2016) Danni Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy

(2016) Jianyin Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Precursors of tRNAs are stabilized by methylguanosine cap structures

(2016) Takayuki Ohira et al.   Nature Chemical Biology

NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNAMet

(2016) Saori Nakano et al.   Nature Chemical Biology

RNA modifications: what have we learned and where are we headed?

(2016) Michaela Frye et al.   NATURE REVIEWS GENETICS

Messenger RNA modifications: Form, distribution, and function

(2016) W. V. Gilbert et al.   SCIENCE

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

(2016) Lindsey Van Haute et al.   Nature Communications

Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma

(2016) Chern Chiuh Woo et al.   Oncotarget

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

(2016) Yong Wu et al.   PLoS Genetics

A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies

(2016) Masakazu Kohda et al.   PLoS Genetics

Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations

(2015) Elena Perli et al.   HUMAN MOLECULAR GENETICS

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

(2015) Osamu Hashizume et al.   Scientific Reports

Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier

(2015) Ana Martínez-Zamora et al.   PLoS One

Mutations in GTPBP3 Cause a Mitochondrial Translation Defect Associated with Hypertrophic Cardiomyopathy, Lactic Acidosis, and Encephalopathy

(2014) Robert Kopajtich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Taurine Ameliorates Impaired the Mitochondrial Function and Prevents Stroke-like Episodes in Patients with MELAS

(2014) Mitsue Rikimaru et al.   INTERNAL MEDICINE

Use of Whole-Exome Sequencing to Determine the Genetic Basis of Multiple Mitochondrial Respiratory Chain Complex Deficiencies

(2014) Robert W. Taylor et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs

(2014) T. Suzuki et al.   NUCLEIC ACIDS RESEARCH

MTO1-Deficient Mouse Model Mirrors the Human Phenotype Showing Complex I Defect and Cardiomyopathy

(2014) Lore Becker et al.   PLoS One

Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD

(2014) Roberto Melero et al.   STRUCTURE

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery

MTO1 Mutations are Associated with Hypertrophic Cardiomyopathy and Lactic Acidosis and Cause Respiratory Chain Deficiency in Humans and Yeast

(2013) Enrico Baruffini et al.   HUMAN MUTATION

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Ribosome profiling reveals features of normal and disease-associated mitochondrial translation

(2013) Koos Rooijers et al.   Nature Communications

Peculiarities of One-Carbon Metabolism in the Strict Carnivorous Cat and the Role in Feline Hepatic Lipidosis

(2013) Adronie Verbrugghe et al.   Nutrients

Mutations of the Mitochondrial-tRNA Modifier MTO1 Cause Hypertrophic Cardiomyopathy and Lactic Acidosis

(2012) Daniele Ghezzi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Control of protein synthesis in yeast mitochondria: The concept of translational activators

(2012) Johannes M. Herrmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification

(2012) Kenjyo Miyauchi et al.   Nature Chemical Biology

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Human Mitochondrial tRNAs: Biogenesis, Function, Structural Aspects, and Diseases

(2011) Tsutomu Suzuki et al.   Annual Review of Genetics

Taurine-containing Uridine Modifications in tRNA Anticodons Are Required to Decipher Non-universal Genetic Codes in Ascidian Mitochondria

(2011) Takeo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria

(2011) O. Z. Karicheva et al.   NUCLEIC ACIDS RESEARCH

Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs

(2011) Suzuki Tsutomu et al.   Wiley Interdisciplinary Reviews-RNA

Acute liver failure with subsequent cirrhosis as the primary manifestation of TRMU mutations

(2010) Ulrike Schara et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea

(2010) Yoshiho Ikeuchi et al.   Nature Chemical Biology

Acute Infantile Liver Failure Due to Mutations in the TRMU Gene

(2009) Avraham Zeharia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Co-translational membrane insertion of mitochondrially encoded proteins

(2009) Martin Ott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

G-Domain Dimerization Orchestrates the tRNA Wobble Modification Reaction in the MnmE/GidA Complex

(2009) Simon Meyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions

(2009) Ismaïl Moukadiri et al.   NUCLEIC ACIDS RESEARCH

Unconventional decoding of the AUA codon as methionine by mitochondrial tRNA Met with the anticodon f 5 CAU as revealed with a mitochondrial in vitro translation system

(2009) Chie Takemoto et al.   NUCLEIC ACIDS RESEARCH

Conserved Cysteine Residues of GidA Are Essential for Biogenesis of 5-Carboxymethylaminomethyluridine at tRNA Anticodon

(2009) Takuo Osawa et al.   STRUCTURE

Comparison of taurine biosynthesis ability between juveniles of Japanese flounder and common carp

(2008) S.-K. Kim et al.   AMINO ACIDS

Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding

(2008) Shinya Kurata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

(2008) Goro KIKUCHI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES