Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine

Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion

(2015) Jean-Christophe Larsimont et al.   Cell Stem Cell

SOX9 Maintains Reserve Stem Cells and Preserves Radioresistance in Mouse Small Intestine

(2015) Kyle C. Roche et al.   GASTROENTEROLOGY

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele

(2014) O. Basak et al.   EMBO JOURNAL

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

(2014) William J. Faller et al.   NATURE

Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism

(2014) Kiruthika Selvadurai et al.   Nature Chemical Biology

SOX9 directly regulates IGFBP-4 in the intestinal epithelium

(2013) Zhongcheng Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

(2013) Ciara Metcalfe et al.   Cell Stem Cell

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection

(2013) Wei-Jie Zhou et al.   NATURE

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Brief Report: Dclk1 Deletion in Tuft Cells Results in Impaired Epithelial Repair After Radiation Injury

(2013) Randal May et al.   STEM CELLS

Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression

(2013) Fu-Jung Lin et al.   PLoS Genetics

Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation

(2012) Laurianne Van Landeghem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

The intestinal epithelium tuft cells: specification and function

(2012) François Gerbe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator

(2012) Pierre Close et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Structure and dynamics of a primordial catalytic fold generated by in vitro evolution

(2012) Fa-An Chao et al.   Nature Chemical Biology

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

Translational Control of Cell Division by Elongator

(2012) Fanelie Bauer et al.   Cell Reports

Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia

(2011) J. B. Cordero et al.   Acta Physiologica

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Origin of the brush cell lineage in the mouse intestinal epithelium

(2011) Matthew Bjerknes et al.   DEVELOPMENTAL BIOLOGY

Gastric tuft cells express DCLK1 and are expanded in hyperplasia

(2011) Milena Saqui-Salces et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Elongator Complex Influences Telomeric Gene Silencing and DNA Damage Response by Its Role in Wobble Uridine tRNA Modification

(2011) Changchun Chen et al.   PLoS Genetics

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

(2010) S. W. Lane et al.   BLOOD

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

(2010) R. K. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin

(2009) Catherine Creppe et al.   CELL

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice

(2009) Payel Bhanja et al.   PLoS One

The Elongator Complex Interacts with PCNA and Modulates Transcriptional Silencing and Sensitivity to DNA Damage Agents

(2009) Qing Li et al.   PLoS Genetics

An Iron-Sulfur Cluster Domain in Elp3 Important for the Structural Integrity of Elongator

(2008) Catherine Greenwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration

(2008) L. D. Johansen et al.   JOURNAL OF CELL SCIENCE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5

(2008) Takako Hattori et al.   NUCLEIC ACIDS RESEARCH

Insulin Receptor Substrate-1 Deficiency Promotes Apoptosis in the Putative Intestinal Crypt Stem Cell Region, Limits Apcmin/+Tumors, and Regulates Sox9

(2007) Nicole M. Ramocki et al.   ENDOCRINOLOGY