Role of the Mre11 Complex in Preserving Genome Integrity

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair

(2018) Aleem Syed et al.   Annual Review of Biochemistry

The MRX complex regulates Exo1 resection activity by altering DNA end structure

(2018) Elisa Gobbini et al.   EMBO JOURNAL

Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning

(2018) Luca Menin et al.   EMBO REPORTS

Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1

(2018) Oliver Limbo et al.   MOLECULAR BIOLOGY OF THE CELL

Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance

(2018) Corinne Cassani et al.   NUCLEIC ACIDS RESEARCH

Interdependent and separable functions ofCaenorhabditis elegansMRN-C complex members couple formation and repair of meiotic DSBs

(2018) Chloe Girard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

(2018) Bryan A Leland et al.   eLife

Regulatory control of DNA end resection by Sae2 phosphorylation

(2018) Elda Cannavo et al.   Nature Communications

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

(2018) Sara Przetocka et al.   MOLECULAR CELL

Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability

(2018) Julyun Oh et al.   Cell Reports

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

(2017) Weibin Wang et al.   GENES & DEVELOPMENT

Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection

(2017) Giordano Reginato et al.   GENES & DEVELOPMENT

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae

(2017) Christopher D. Putnam et al.   GENETICS

Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges

(2017) Anissia Ait Saada et al.   MOLECULAR CELL

Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair

(2017) Logan R. Myler et al.   MOLECULAR CELL

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

(2017) Marko Vujanovic et al.   MOLECULAR CELL

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

(2017) Angelo Taglialatela et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A global view of meiotic double-strand break end resection

(2017) Eleni P. Mimitou et al.   SCIENCE

The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks

(2017) Ana Teixeira-Silva et al.   Nature Communications

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression

(2017) Jun Hyun Kim et al.   Cell Reports

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae

(2017) Christopher D. Putnam et al.   GENETICS

Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex

(2016) Julyun Oh et al.   MOLECULAR CELL

RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together

(2016) Andrew Seeber et al.   MOLECULAR CELL

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

(2016) Roopesh Anand et al.   MOLECULAR CELL

Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

(2016) Corinne Cassani et al.   PLOS BIOLOGY

Synthetic viability genomic screening defines Sae2 function in DNA repair

(2015) F. Puddu et al.   EMBO JOURNAL

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection

(2015) D. Bonetti et al.   EMBO REPORTS

Phosphorylation of Sae2 Mediates Forkhead-associated (FHA) Domain-specific Interaction and Regulates Its DNA Repair Function

(2015) Jason Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification

(2015) Sarah K. Deng et al.   MOLECULAR CELL

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CtIP tetramer assembly is required for DNA-end resection and repair

(2015) Owen R Davies et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

(2015) Sara N Andres et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

(2015) María Belén Vallerga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling

(2015) Huan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

CtIP tetramer assembly is required for DNA-end resection and repair

(2015) Owen R Davies et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

(2015) Sara N Andres et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein

(2015) Prabha Sarangi et al.   PLoS Genetics

Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity

(2015) Elisa Gobbini et al.   PLoS Genetics

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

(2015) Matteo Ferrari et al.   PLoS Genetics

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

(2014) R. A. Deshpande et al.   EMBO JOURNAL

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

(2014) R. Roset et al.   GENES & DEVELOPMENT

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

(2014) Andreas Sturzenegger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

(2014) Federica Polato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity

(2014) Hailong Wang et al.   MOLECULAR CELL

Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection

(2014) Nodar Makharashvili et al.   MOLECULAR CELL

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures

(2014) Christopher D. Putnam et al.   PLoS Genetics

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

(2013) Elisa Gobbini et al.   DNA REPAIR

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

(2013) Ji-Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation-Regulated Transitions in an Oligomeric State Control the Activity of the Sae2 DNA Repair Enzyme

(2013) Qiong Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repair of Double-Strand Breaks by End Joining

(2013) K. K. Chiruvella et al.   Cold Spring Harbor Perspectives in Biology

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

(2013) Hailong Wang et al.   PLoS Genetics

Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

(2012) S. Ying et al.   CANCER RESEARCH

Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End

(2012) R. J. Wellinger et al.   GENETICS

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

(2012) Mireille Tittel-Elmer et al.   MOLECULAR CELL

Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

(2012) Christian B Schiller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

(2011) Katja Lammens et al.   CELL

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

(2011) Karen Finn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crystal structure of the Mre11-Rad50-ATP S complex: understanding the interplay between Mre11 and Rad50

(2011) H. S. Lim et al.   GENES & DEVELOPMENT

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Analysis of protein dynamics at active, stalled, and collapsed replication forks

(2011) B. M. Sirbu et al.   GENES & DEVELOPMENT

Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends

(2011) K. Fukunaga et al.   MOLECULAR AND CELLULAR BIOLOGY

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

(2011) Marcel Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

(2011) Carolin Möckel et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations

(2011) Young Bong Park et al.   STRUCTURE

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

Separable roles for Exonuclease I in meiotic DNA double-strand break repair

(2010) Rebecca E. Keelagher et al.   DNA REPAIR

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

E. coli SbcCD and RecA Control Chromosomal Rearrangement Induced by an Interrupted Palindrome

(2010) Elise Darmon et al.   MOLECULAR CELL

Temporally and Biochemically Distinct Activities of Exo1 during Meiosis: Double-Strand Break Resection and Resolution of Double Holliday Junctions

(2010) Kseniya Zakharyevich et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting

(2010) Woo-Hyun Chung et al.   PLoS Genetics

Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

(2009) Regina Waltes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

(2009) R. Scott Williams et al.   CELL

A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage

(2009) Janette Lloyd et al.   CELL

PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

(2009) Michela Di Virgilio et al.   DNA REPAIR

DNA end resection: Many nucleases make light work

(2009) Eleni P. Mimitou et al.   DNA REPAIR

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress

(2009) Mireille Tittel-Elmer et al.   EMBO JOURNAL

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles for NBS1 in Alternative Nonhomologous End-Joining of V(D)J Recombination Intermediates

(2009) Ludovic Deriano et al.   MOLECULAR CELL

Rif1 and Rif2 Inhibit Localization of Tel1 to DNA Ends

(2009) Yukinori Hirano et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Multiple functions of MRN in end-joining pathways during isotype class switching

(2009) Maria Dinkelmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

(2009) Eddy van der Linden et al.   NUCLEIC ACIDS RESEARCH

Interplay of Mre11 Nuclease with Dna2 plus Sgs1 in Rad51-Dependent Recombinational Repair

(2009) Martin E. Budd et al.   PLoS One

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

(2008) Christian Zierhut et al.   EMBO JOURNAL

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

Forkhead-Associated Domain of Yeast Xrs2, a Homolog of Human Nbs1, Promotes Nonhomologous End Joining Through Interaction With a Ligase IV Partner Protein, Lif1

(2008) K. Matsuzaki et al.   GENETICS

Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 Complex to a Double-Strand Break Requires Interactions With Yku80 and the Xrs2 FHA Domain

(2008) P. L. Palmbos et al.   GENETICS

Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae

(2008) D. Wu et al.   GENETICS

Structure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage Sites

(2008) Chao Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

The Kleisin Subunit of Cohesin Dictates Damage-Induced Cohesion

(2008) Jill M. Heidinger-Pauli et al.   MOLECULAR CELL

SbcCD Causes a Double-Strand Break at a DNA Palindrome in the Escherichia coli Chromosome

(2008) John K. Eykelenboom et al.   MOLECULAR CELL

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

(2008) Kihoon Lee et al.   NATURE

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics