Eukaryotic Rad50 functions as a rod-shaped dimer

The biological inorganic chemistry of zinc ions

(2016) Artur Krężel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural mechanism of ATP‐dependent DNA binding and DNA end bridging by eukaryotic Rad50

(2016) Florian Ulrich Seifert et al.   EMBO JOURNAL

Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex

(2016) Julyun Oh et al.   MOLECULAR CELL

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

ATP‐dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex

(2015) Yaqi Liu et al.   EMBO JOURNAL

Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain

(2015) Tasida Barfoot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interdependence of the Rad50 Hook and Globular Domain Functions

(2015) Marcel Hohl et al.   MOLECULAR CELL

Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA Binding

(2015) Young-Min Soh et al.   MOLECULAR CELL

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair

(2015) Julien Lafrance-Vanasse et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Structure of the Rad50 DNA double‐strand break repair protein in complex with DNA

(2014) Anna Rojowska et al.   EMBO JOURNAL

DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA

(2014) S. Sung et al.   EMBO JOURNAL

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

(2014) R. A. Deshpande et al.   EMBO JOURNAL

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

(2014) R. Roset et al.   GENES & DEVELOPMENT

Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

(2014) H. Al-Ahmadie et al.   Cancer Discovery

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

(2013) Ji-Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Femtomolar Zn(ii) affinity of minimal zinc hook peptides – a promising small tag for protein engineering

(2012) Tomasz Kochańczyk et al.   CHEMICAL COMMUNICATIONS

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

(2012) Mireille Tittel-Elmer et al.   MOLECULAR CELL

Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

(2012) Christian B Schiller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

(2011) Katja Lammens et al.   CELL

Mre11–Rad50 complex crystals suggest molecular calisthenics

(2011) Claire Wyman et al.   DNA REPAIR

Crystal structure of the Mre11-Rad50-ATP S complex: understanding the interplay between Mre11 and Rad50

(2011) H. S. Lim et al.   GENES & DEVELOPMENT

ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control

(2011) Magtouf Gatei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

(2011) Marcel Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair

(2011) Gareth J Williams et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

(2011) Carolin Möckel et al.   NUCLEIC ACIDS RESEARCH

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

(2009) Eddy van der Linden et al.   NUCLEIC ACIDS RESEARCH

An Efficient Fmoc-SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation

(2008) Juan B. Blanco-Canosa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL