Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

(2011) Katja Lammens et al.   CELL

Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly

(2011) Yoshiyuki Matsumoto et al.   DNA REPAIR

Crystal structure of the Mre11-Rad50-ATP S complex: understanding the interplay between Mre11 and Rad50

(2011) H. S. Lim et al.   GENES & DEVELOPMENT

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

(2011) Emil Mladenov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair

(2011) Gareth J Williams et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

(2011) Carolin Möckel et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations

(2011) Young Bong Park et al.   STRUCTURE

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

(2010) Elias A. Rahal et al.   CELL CYCLE

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

Multiple roles of ATM in monitoring and maintaining DNA integrity

(2010) Frederick A. Derheimer et al.   FEBS LETTERS

Cdc13 and Telomerase Bind through Different Mechanisms at the Lagging- and Leading-Strand Telomeres

(2010) Virginie Faure et al.   MOLECULAR CELL

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae

(2010) Ryan Janke et al.   NUCLEIC ACIDS RESEARCH

Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

(2009) Regina Waltes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

(2009) R. Scott Williams et al.   CELL

A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage

(2009) Janette Lloyd et al.   CELL

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS

(2009) E. R.P. Shull et al.   GENES & DEVELOPMENT

Two Brothers with Ataxia-Telangiectasia-like Disorder with Lung Adenocarcinoma

(2009) Naoki Uchisaka et al.   JOURNAL OF PEDIATRICS

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

(2009) Eddy van der Linden et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

(2008) Kihoon Lee et al.   NATURE