Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

Rad9/53BP1 protects stalled replication forks from degradation in Mec1/ATR‐defective cells

(2018) Matteo Villa et al.   EMBO REPORTS

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

(2017) Stephanie A. Yazinski et al.   GENES & DEVELOPMENT

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Biallelic inactivation of REV7 is associated with Fanconi anemia

(2016) Dominique Bluteau et al.   JOURNAL OF CLINICAL INVESTIGATION

HELB Is a Feedback Inhibitor of DNA End Resection

(2016) Ján Tkáč et al.   MOLECULAR CELL

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable

(2016) Kristi L. Jensen et al.   NUCLEIC ACIDS RESEARCH

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors

(2015) Christopher J. Lord et al.   Annual Review of Medicine

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection

(2015) D. Bonetti et al.   EMBO REPORTS

The multifaceted roles of the HORMA domain in cellular signaling

(2015) Scott C. Rosenberg et al.   JOURNAL OF CELL BIOLOGY

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

(2015) Joaquin Mateo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair

(2015) Lijuan Ma et al.   NUCLEIC ACIDS RESEARCH

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

(2015) Matteo Ferrari et al.   PLoS Genetics

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

(2014) Federica Polato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for nuclear envelope–bridging complexes in homology-directed repair

(2014) Rebecca K. Swartz et al.   MOLECULAR BIOLOGY OF THE CELL

Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules

(2014) Bryan Gibb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Dynamics during Early Double-Strand Break Processing Revealed by Non-Intrusive Imaging of Living Cells

(2014) Hicham Saad et al.   PLoS Genetics

Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

(2013) M. Aggarwal et al.   CANCER RESEARCH

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Mechanisms of Resistance to PARP Inhibitors—Three and Counting

(2013) Tito Fojo et al.   Cancer Discovery

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

(2012) Xuefeng Chen et al.   NATURE

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors

(2012) Janneke E. Jaspers et al.   Cancer Discovery

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Lac operator repeats generate a traceable fragile site in mammalian cells

(2011) Ariana Jacome et al.   EMBO REPORTS

Regulation of gene expression at the fission yeast Schizosaccharomyces pombe urg1 locus

(2011) Adam T. Watson et al.   GENE

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes

(2010) Jill M. Grimme et al.   NUCLEIC ACIDS RESEARCH

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

(2010) W. M. Hicks et al.   SCIENCE

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

urg1: A Uracil-Regulatable Promoter System for Fission Yeast with Short Induction and Repression Times

(2008) Stephen Watt et al.   PLoS One

Modules for cloning-free chromatin tagging inSaccharomyces cerevisae

(2008) Sabine Rohner et al.   YEAST

Gene tagging and gene replacement using recombinase-mediated cassette exchange in Schizosaccharomyces pombe

(2007) Adam T. Watson et al.   GENE