Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity

Synthetic viability genomic screening defines Sae2 function in DNA repair

(2015) F. Puddu et al.   EMBO JOURNAL

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection

(2015) D. Bonetti et al.   EMBO REPORTS

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition

(2015) Hiroo Ogi et al.   MOLECULAR BIOLOGY OF THE CELL

The 9-1-1 checkpoint clamp coordinates resection at DNA double strand breaks

(2015) Greg H.P. Ngo et al.   NUCLEIC ACIDS RESEARCH

Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling

(2015) Huan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

(2015) Matteo Ferrari et al.   PLoS Genetics

PIKKs — the solenoid nest where partners and kinases meet

(2014) Domagoj Baretić et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

(2013) Elisa Gobbini et al.   DNA REPAIR

Resection Activity of the Sgs1 Helicase Alters the Affinity of DNA Ends for Homologous Recombination Proteins in Saccharomyces cerevisiae

(2013) K. A. Bernstein et al.   GENETICS

ATM signalling and cancer

(2013) C A Cremona et al.   ONCOGENE

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

(2012) Anna Maria Hegnauer et al.   EMBO JOURNAL

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends

(2011) K. Fukunaga et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage

(2011) S. S. Foster et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Cdk1 Requirements during Single-Strand Annealing, Noncrossover, and Crossover Recombination

(2011) Camilla Trovesi et al.   PLoS Genetics

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Maintenance of the DNA-Damage Checkpoint Requires DNA-Damage-Induced Mediator Protein Oligomerization

(2009) Takehiko Usui et al.   MOLECULAR CELL

Rif1 and Rif2 Inhibit Localization of Tel1 to DNA Ends

(2009) Yukinori Hirano et al.   MOLECULAR CELL

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

(2008) Isabelle Morin et al.   EMBO JOURNAL

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE