Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1

The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression

(2017) Jun Hyun Kim et al.   Cell Reports

Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex

(2016) Julyun Oh et al.   MOLECULAR CELL

Structure of the intact ATM/Tel1 kinase

(2016) Xuejuan Wang et al.   Nature Communications

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair

(2015) Julien Lafrance-Vanasse et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

(2014) R. A. Deshpande et al.   EMBO JOURNAL

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

(2013) Ji-Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Tel1ATM and Rad3ATR phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast

(2012) H. Yamazaki et al.   GENES & DEVELOPMENT

Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

(2012) Christian B Schiller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

(2012) Oliver Limbo et al.   NUCLEIC ACIDS RESEARCH

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

(2011) Katja Lammens et al.   CELL

Crystal structure of the Mre11-Rad50-ATP S complex: understanding the interplay between Mre11 and Rad50

(2011) H. S. Lim et al.   GENES & DEVELOPMENT

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair

(2011) Gareth J Williams et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast

(2011) Bettina A Moser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

(2011) Carolin Möckel et al.   NUCLEIC ACIDS RESEARCH

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

Mre11 Nuclease Activity and Ctp1 Regulate Chk1 Activation by Rad3ATR and Tel1ATM Checkpoint Kinases at Double-Strand Breaks

(2010) O. Limbo et al.   MOLECULAR AND CELLULAR BIOLOGY

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

A Kinase-Independent Role for the Rad3ATR-Rad26ATRIP Complex in Recruitment of Tel1ATM to Telomeres in Fission Yeast

(2010) Lakxmi Subramanian et al.   PLoS Genetics

Rad3ATR Decorates Critical Chromosomal Domains with γH2A to Protect Genome Integrity during S-Phase in Fission Yeast

(2010) Sophie Rozenzhak et al.   PLoS Genetics

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

(2009) R. Scott Williams et al.   CELL

A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage

(2009) Janette Lloyd et al.   CELL

Two Brothers with Ataxia-Telangiectasia-like Disorder with Lung Adenocarcinoma

(2009) Naoki Uchisaka et al.   JOURNAL OF PEDIATRICS

Meiotic DNA Double-Strand Break Repair Requires Two Nucleases, MRN and Ctp1, To Produce a Single Size Class of Rec12 (Spo11)-Oligonucleotide Complexes

(2009) N. Milman et al.   MOLECULAR AND CELLULAR BIOLOGY

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

(2008) Ali Jazayeri et al.   EMBO JOURNAL

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

(2008) Jeremy A. Daniel et al.   JOURNAL OF CELL BIOLOGY