Endosomal trafficking regulates receptor-mediated transcytosis of antibodies across the blood brain barrier

Brain penetration, target engagement, and disposition of the blood–brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1

(2016) Carl I. Webster et al.   FASEB JOURNAL

Into rather unexplored terrain-transcellular transport across the blood-brain barrier

(2016) Marijke De Bock et al.   GLIA

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

(2016) Y. Joy Yu Zuchero et al.   NEURON

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

(2016) Roberto Villaseñor et al.   Scientific Reports

Cargo Delivery into the Brain by in vivo identified Transport Peptides

(2015) Eduard Urich et al.   Scientific Reports

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

A novel platform for engineering blood-brain barrier-crossing bispecific biologics

(2014) Graham K. Farrington et al.   FASEB JOURNAL

The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release

(2014) C. A. Escudero et al.   JOURNAL OF CELL SCIENCE

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding

(2014) Hadassah Sade et al.   PLoS One

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

Neonatal Fc Receptor and its Role in the Absorption, Distribution, Metabolism and Excretion of Immunoglobulin G-Based Biotherapeutics

(2013) Craig Giragossian et al.   CURRENT DRUG METABOLISM

Dynamics within tetraspanin pairs affect MHC class II expression

(2012) T. van den Hoorn et al.   JOURNAL OF CELL SCIENCE

Multiplexed Evaluation of Serum and CSF Pharmacokinetics of Brain-Targeting Single-Domain Antibodies Using a NanoLC–SRM-ILIS Method

(2012) Arsalan S. Haqqani et al.   MOLECULAR PHARMACEUTICS

Get on the exosome bus with ALIX

(2012) James H. Hurley et al.   NATURE CELL BIOLOGY

Neutralization ofClostridium difficileToxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain

(2011) Greg Hussack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

(2011) Christopher S. Von Bartheld et al.   PROGRESS IN NEUROBIOLOGY

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Kinetic analysis of novel mono- and multivalent VHH-fragments and their application for molecular imaging of brain tumours

(2010) U Iqbal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein

(2010) Ruben J. Boado et al.   JOURNAL OF BIOTECHNOLOGY

Molecular mechanisms of clathrin-independent endocytosis

(2009) C. G. Hansen et al.   JOURNAL OF CELL SCIENCE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro

(2008) Pietra Candela et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH