Use of LDL receptor–targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier

Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor

(2016) Guillaume Jacquot et al.   MOLECULAR PHARMACEUTICS

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

(2015) Anita Ramanathan et al.   Frontiers in Aging Neuroscience

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

(2014) Brian Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of Five Peptide Vectors for Improved Brain Delivery of the Lysosomal Enzyme Arylsulfatase A

(2014) A. Bockenhoff et al.   JOURNAL OF NEUROSCIENCE

ANG4043, a Novel Brain-Penetrant Peptide-mAb Conjugate, Is Efficacious against HER2-Positive Intracranial Tumors in Mice

(2014) A. Regina et al.   MOLECULAR CANCER THERAPEUTICS

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding

(2014) Hadassah Sade et al.   PLoS One

Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood–Brain Barrier

(2014) Julia Georgieva et al.   Pharmaceutics

LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma

(2013) Bo Zhang et al.   BIOMATERIALS

A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box

(2013) Luca Cucullo et al.   BMC NEUROSCIENCE

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn

(2013) Philip R. Cooper et al.   BRAIN RESEARCH

Bispecific antibodies for delivery into the brain

(2013) Ryan J Watts et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA

(2013) Nicolina Cristina Sorrentino et al.   EMBO Molecular Medicine

Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier

(2013) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

(2012) J. E. Vance   Disease Models & Mechanisms

High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism

(2012) Nutabi Camargo et al.   FASEB JOURNAL

Chemical Optimization of New Ligands of the Low-Density Lipoprotein Receptor as Potential Vectors for Central Nervous System Targeting

(2012) Jean-Daniel Malcor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Medicinal Chemistry Based Approaches and Nanotechnology-Based Systems to Improve CNS Drug Targeting and Delivery

(2012) Patrick Vlieghe et al.   MEDICINAL RESEARCH REVIEWS

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes

(2010) M. Valenza et al.   JOURNAL OF NEUROSCIENCE

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones

(2009) Anja Zensi et al.   JOURNAL OF CONTROLLED RELEASE

Endothelial transcytosis in health and disease

(2008) Maya Simionescu et al.   CELL AND TISSUE RESEARCH

Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro

(2008) Pietra Candela et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

A Unique Carrier for Delivery of Therapeutic Compounds beyond the Blood-Brain Barrier

(2008) Delara Karkan et al.   PLoS One