Engineering Immune Tolerance with Biomaterials

A poly(beta-amino ester) activates macrophages independent of NF-κB signaling

(2018) Neil M. Dold et al.   Acta Biomaterialia

Controlled release of an HDAC inhibitor for reduction of inflammation in dry eye disease

(2018) Michelle L. Ratay et al.   Acta Biomaterialia

The microbiome and autoimmunity: a paradigm from the gut–liver axis

(2018) Bo Li et al.   Cellular & Molecular Immunology

Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice

(2018) Yulin Chen et al.   DIABETOLOGIA

Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells

(2018) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Soluble antigen arrays disarm antigen-specific B cells to promote lasting immune tolerance in experimental autoimmune encephalomyelitis

(2018) Brittany L. Hartwell et al.   JOURNAL OF AUTOIMMUNITY

Targeting DEC-205−DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis

(2018) Inna Tabansky et al.   MOLECULAR MEDICINE

Regulatory T cells in autoimmune disease

(2018) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

Designing natural and synthetic immune tissues

(2018) Emily A. Gosselin et al.   NATURE MATERIALS

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

(2018) Devon M. Headen et al.   NATURE MATERIALS

Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity

(2018) Ronit Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Vaccine and Immunotherapy Design Using Biomaterials

(2018) Michelle L. Bookstaver et al.   TRENDS IN IMMUNOLOGY

Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis

(2018) Robert A. LaMothe et al.   Frontiers in Immunology

Self-Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation

(2018) Michelle L. Bookstaver et al.   Small

Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31

(2018) Naihan Chen et al.   Advanced Healthcare Materials

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

(2018) Amine Meliani et al.   Nature Communications

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Control of autoimmune inflammation using liposomes to deliver positive allosteric modulators of metabotropic glutamate receptors

(2017) Joshua M. Gammon et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Impact of molecular weight on the intrinsic immunogenic activity of poly(beta amino esters)

(2017) James I. Andorko et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease

(2017) Michelle L. Ratay et al.   JOURNAL OF CONTROLLED RELEASE

In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis

(2017) Stephen C. Balmert et al.   JOURNAL OF CONTROLLED RELEASE

Pulmonary Administration of Soluble Antigen Arrays Is Superior to Antigen in Treatment of Experimental Autoimmune Encephalomyelitis

(2017) Christopher Kuehl et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance

(2017) Robert Kuo et al.   MOLECULAR THERAPY

Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates

(2017) Ryan M. Pearson et al.   MOLECULAR THERAPY

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

(2017) Santiswarup Singha et al.   Nature Nanotechnology

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

(2017) Peter Popp Wibroe et al.   Nature Nanotechnology

Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice

(2017) Su Ji Jeong et al.   NEUROBIOLOGY OF DISEASE

Bioengineering of an Intraabdominal Endocrine Pancreas

(2017) David A. Baidal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intralymphatic Injection of Autoantigen in Type 1 Diabetes

(2017) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

(2017) Novalia Pishesha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation

(2017) Catia S. Verbeke et al.   Advanced Healthcare Materials

TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model

(2017) Michelle L. Ratay et al.   Scientific Reports

Assembly and Immunological Processing of Polyelectrolyte Multilayers Composed of Antigens and Adjuvants

(2016) Yu-Chieh Chiu et al.   ACS Applied Materials & Interfaces

Design of Polyelectrolyte Multilayers to Promote Immunological Tolerance

(2016) Lisa H. Tostanoski et al.   ACS Nano

Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation

(2016) James I. Andorko et al.   Acta Biomaterialia

Immune Tolerance for Autoimmune Disease and Cell Transplantation

(2016) Xunrong Luo et al.   Annual Review of Biomedical Engineering

Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation

(2016) Kelan A. Hlavaty et al.   BIOMATERIALS

Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets

(2016) Jeffrey M.H. Liu et al.   BIOMATERIALS

Impact of dose, route, and composition on the immunogenicity of immune polyelectrolyte multilayers delivered on gold templates

(2016) Peipei Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Tolerogenic nanoparticles to induce immunologic tolerance: Prevention and reversal of FVIII inhibitor formation

(2016) Ai-Hong Zhang et al.   CELLULAR IMMUNOLOGY

Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy

(2016) Kamal D. Srivastava et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization of the Protective Role of Regulatory T Cells in Experimental Periapical Lesion Development and Their Chemoattraction Manipulation as a Therapeutic Tool

(2016) Carolina Favaro Francisconi et al.   JOURNAL OF ENDODONTICS

Molecular Dynamics of Multivalent Soluble Antigen Arrays Support a Two-Signal Co-delivery Mechanism in the Treatment of Experimental Autoimmune Encephalomyelitis

(2016) Brittany L. Hartwell et al.   MOLECULAR PHARMACEUTICS

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

(2016) Takashi K. Kishimoto et al.   Nature Nanotechnology

Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization

(2016) Charles B. Smarr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

Biomedical Potential of mTOR Modulation by Nanoparticles

(2016) Laura Hulea et al.   TRENDS IN BIOTECHNOLOGY

Native cellulose nanofibrills induce immune tolerance in vitro by acting on dendritic cells

(2016) Sergej Tomić et al.   Scientific Reports

Targeted Delivery of Immunomodulators to Lymph Nodes

(2016) Jamil Azzi et al.   Cell Reports

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

(2016) Lisa H. Tostanoski et al.   Cell Reports

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

Polyelectrolyte Multilayers Assembled Entirely from Immune Signals on Gold Nanoparticle Templates Promote Antigen-Specific T Cell Response

(2015) Peipei Zhang et al.   ACS Nano

Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids

(2015) Hong Yang et al.   ACS Nano

Towards programming immune tolerance through geometric manipulation of phosphatidylserine

(2015) Reid A. Roberts et al.   BIOMATERIALS

Paracrine co-delivery of TGF-β and IL-2 using CD4-targeted nanoparticles for induction and maintenance of regulatory T cells

(2015) Michael D. McHugh et al.   BIOMATERIALS

Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection

(2015) Shusen Wang et al.   CELL TRANSPLANTATION

A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice

(2015) Jamal S. Lewis et al.   CLINICAL IMMUNOLOGY

IL-4/CCL22/CCR4 Axis Controls Regulatory T-Cell Migration That Suppresses Inflammatory Bone Loss in Murine Experimental Periodontitis

(2015) Ana Claudia Araujo-Pires et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity

(2015) Joshua M. Gammon et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

(2015) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice

(2015) Kotaro Otomo et al.   JOURNAL OF IMMUNOLOGY

DEC205+Dendritic Cell–Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis

(2015) Rachel Spiering et al.   JOURNAL OF IMMUNOLOGY

Routes of Administration and Dose Optimization of Soluble Antigen Arrays in Mice with Experimental Autoimmune Encephalomyelitis

(2015) Sharadvi Thati et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

(2015) Geoffrey M Lynn et al.   NATURE BIOTECHNOLOGY

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

(2015) Randall A. Meyer et al.   Small

In vivo capture and label-free detection of early metastatic cells

(2015) Samira M. Azarin et al.   Nature Communications

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

(2015) Alizée J. Grimm et al.   Scientific Reports

A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice

(2015) Young Mee Yoon et al.   Scientific Reports

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

(2015) Marie Ballester et al.   Scientific Reports

Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells

(2015) Catia S. Verbeke et al.   Advanced Healthcare Materials

Modular Vaccine Design Using Carrier-Free Capsules Assembled from Polyionic Immune Signals

(2015) Yu-Chieh Chiu et al.   ACS Biomaterials-Science & Engineering

Modular Vaccine Design Using Carrier-Free Capsules Assembled from Polyionic Immune Signals

(2015) Yu-Chieh Chiu et al.   ACS Biomaterials Science & Engineering

Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase

(2015) K. M. Lorentz et al.   Science Advances

Co-Delivery of Autoantigen and B7 Pathway Modulators Suppresses Experimental Autoimmune Encephalomyelitis

(2014) Laura Northrup et al.   AAPS Journal

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Large Graphene Quantum Dots Alleviate Immune-Mediated Liver Damage

(2014) Vladislav Volarevic et al.   ACS Nano

Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation

(2014) Jane Bryant et al.   BIOMATERIALS

Treatment of Experimental Autoimmune Encephalomyelitis by Codelivery of Disease Associated Peptide and Dexamethasone in Acetalated Dextran Microparticles

(2014) Kevin J. Peine et al.   MOLECULAR PHARMACEUTICS

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo

(2013) Kenichi Niikura et al.   ACS Nano

The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus

(2013) Michael Look et al.   BIOMATERIALS

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Quantifying the importance of pMHC valency, total pMHC dose and frequency on nanoparticle therapeutic efficacy

(2013) Jordan Sugarman et al.   IMMUNOLOGY AND CELL BIOLOGY

Is intralymphatic immunotherapy ready for clinical use in patients with grass pollen allergy?

(2013) Marianne Witten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice

(2013) Michael Look et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyaluronic Acid Graft Polymers Displaying Peptide Antigen Modulate Dendritic Cell Response in Vitro

(2013) Chuda Chittasupho et al.   MOLECULAR PHARMACEUTICS

Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes

(2013) A. J. Glowacki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

PLG Scaffold Delivered Antigen-Specific Regulatory T Cells Induce Systemic Tolerance in Autoimmune Diabetes

(2013) John G. Graham et al.   TISSUE ENGINEERING PART A

Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres

(2013) Jamal S. Lewis et al.   Journal of Materials Chemistry B

Bioinspired Controlled Release of CCL22 Recruits Regulatory T Cells In Vivo

(2012) Siddharth Jhunjhunwala et al.   ADVANCED MATERIALS

Microparticle surface modifications targeting dendritic cells for non-activating applications

(2012) Jamal S. Lewis et al.   BIOMATERIALS

Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading

(2012) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells

(2012) Siddharth Jhunjhunwala et al.   JOURNAL OF CONTROLLED RELEASE

Ethylenecarbodiimide-Fixed Donor Splenocyte Infusions Differentially Target Direct and Indirect Pathways of Allorecognition for Induction of Transplant Tolerance

(2012) T. Kheradmand et al.   JOURNAL OF IMMUNOLOGY

Nanoparticle Hydrophobicity Dictates Immune Response

(2012) Daniel F. Moyano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vaccine-like Controlled-Release Delivery of an Immunomodulating Peptide To Treat Experimental Autoimmune Encephalomyelitis

(2012) Barlas Büyüktimkin et al.   MOLECULAR PHARMACEUTICS

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

(2012) S. Kontos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

(2012) A. Yeste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating Human Autoimmunity: Current Practice and Future Prospects

(2012) M. D. Rosenblum et al.   Science Translational Medicine

Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions

(2011) Taba Kheradmand et al.   BIOMATERIALS

The impact of nanoparticle ligand density on dendritic-cell targeted vaccines

(2011) Arunima Bandyopadhyay et al.   BIOMATERIALS

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen

(2011) T. L. McGaha et al.   BLOOD

Intra-Lymph Node Prime-Boost Vaccination against Melan A and Tyrosinase for the Treatment of Metastatic Melanoma: Results of a Phase 1 Clinical Trial

(2011) A. Ribas et al.   CLINICAL CANCER RESEARCH

Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells

(2011) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA