期刊
ADVANCED HEALTHCARE MATERIALS
卷 8, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201801419
关键词
biomaterials; immunology and autoimmunity; microparticles and nanoparticles; nanotechnology; scaffolds; tolerance; vaccine and immunotherapy
资金
- United States Department of Veterans Affairs [1I01BX003690]
- National Institutes of Health [R01EB026896]
- Damon Runyon Foundation [DRR3415]
- NSF CAREER [1351688]
- PhRMA Foundation Pharmaceutics Program
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1351688] Funding Source: National Science Foundation
Autoimmune diseases, rejection of transplanted organs and grafts, chronic inflammatory diseases, and immune-mediated rejection of biologic drugs impact a large number of people across the globe. New understanding of immune function is revealing exciting opportunities to help tackle these challenges by harnessingor correctingthe specificity of immune function. However, realizing this potential requires precision control over the interaction between regulatory immune cues, antigens attacked during inflammation, and the tissues where these processes occur. Engineered materialssuch as polymeric and lipid particles, scaffolds, and inorganic materialsoffer powerful features that can help to selectively regulate immune function during disease without compromising healthy immune functions. This review highlights some of the exciting developments to leverage biomaterials as carriers, depots, scaffoldsand even as agents with intrinsic immunomodulatory featuresto promote immunological tolerance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据