- Home
- Publications
- Publication Search
- Publication Details
Title
The role of klotho in chronic kidney disease
Authors
Keywords
-
Journal
BMC Nephrology
Volume 19, Issue 1, Pages -
Publisher
Springer Nature America, Inc
Online
2018-10-22
DOI
10.1186/s12882-018-1094-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Klotho G-395A gene polymorphism: impact on progression of end-stage renal disease and development of cardiovascular complications in children on dialysis
- (2018) Eman A. Elghoroury et al. PEDIATRIC NEPHROLOGY
- α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling
- (2018) Gaozhi Chen et al. NATURE
- Modeled structural basis for the recognition of α2-3-sialyllactose by soluble Klotho
- (2017) Jon D. Wright et al. FASEB JOURNAL
- Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease
- (2017) Toshifumi Sugatani et al. KIDNEY INTERNATIONAL
- Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease
- (2017) Qin Zhang et al. KIDNEY INTERNATIONAL
- Klotho expression in osteocytes regulates bone metabolism and controls bone formation
- (2017) Hirotaka Komaba et al. KIDNEY INTERNATIONAL
- Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy
- (2017) Ming Chang Hu et al. KIDNEY INTERNATIONAL
- Chronic Kidney Disease
- (2017) Angela C Webster et al. LANCET
- The systemic nature of CKD
- (2017) Carmine Zoccali et al. Nature Reviews Nephrology
- Is there a role for newer biomarkers in chronic kidney disease-mineral and bone disorder management?
- (2017) Sven-Jean Tan et al. NEPHROLOGY
- Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
- (2017) George Dalton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kidney Fibrosis
- (2017) Thomas Vanhove et al. TRANSPLANTATION
- Managing Fluid and Electrolyte Disorders in Kidney Disease
- (2017) Cathy Langston VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
- Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice
- (2017) Wenjun Lin et al. Scientific Reports
- Vertebral bone density associates with coronary artery calcification and is an independent predictor of poor outcome in end-stage renal disease patients
- (2016) Zhimin Chen et al. BONE
- The FGF23 and Klotho system beyond mineral metabolism
- (2016) Makoto Kuro-o Clinical and Experimental Nephrology
- Study of pathway cross-talk interactions with NF-κB leading to its activation via ubiquitination or phosphorylation: A brief review
- (2016) Sayantan Ghosh et al. GENE
- Klotho, the Holy Grail of the kidney: from salt sensitivity to chronic kidney disease
- (2016) Rigas G. Kalaitzidis et al. INTERNATIONAL UROLOGY AND NEPHROLOGY
- Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho
- (2016) Julia M. Hum et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Klotho connects intermedin1–53 to suppression of vascular calcification in chronic kidney disease
- (2016) Ming Chang Hu KIDNEY INTERNATIONAL
- Intermedin1–53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho
- (2016) Jin Rui Chang et al. KIDNEY INTERNATIONAL
- In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling
- (2016) Noriko Ide et al. KIDNEY INTERNATIONAL
- Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease
- (2016) Olga A. Agapova et al. KIDNEY INTERNATIONAL
- Fibroblast growth factor 23 and markers of mineral metabolism in individuals with preserved renal function
- (2016) Nasser A. Dhayat et al. KIDNEY INTERNATIONAL
- Enfermedad óseo mineral relacionada con la enfermedad renal crónica: Klotho y FGF23; implicaciones cardiovasculares
- (2016) Laura Salanova Villanueva et al. NEFROLOGIA
- Activation of peroxisome proliferator-activated receptor γ inhibits vascular calcification by upregulating Klotho
- (2016) Lijuan Cheng et al. Experimental and Therapeutic Medicine
- Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport
- (2016) Xiaobin Han et al. PLoS One
- Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells
- (2015) Nicholas W. Chavkin et al. EXPERIMENTAL CELL RESEARCH
- Secreted klotho protein attenuates osteogenic differentiation of human bone marrow mesenchymal stem cellsin vitrovia inactivation of the FGFR1/ERK signaling pathway
- (2015) Wei Zhang et al. GROWTH FACTORS
- Xeno-Klotho Inhibits Parathyroid Hormone Signaling
- (2015) Tsuneo Takenaka et al. JOURNAL OF BONE AND MINERAL RESEARCH
- FGF23 Regulates Bone Mineralization in a 1,25(OH)2D3and Klotho-Independent Manner
- (2015) Sathish Kumar Murali et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Renal Production, Uptake, and Handling of Circulating Klotho
- (2015) M. C. Hu et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Klotho upregulation by rapamycin protects against vascular disease in CKD
- (2015) Takayuki Hamano KIDNEY INTERNATIONAL
- Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats
- (2015) Cynthia S. Ritter et al. KIDNEY INTERNATIONAL
- Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation
- (2015) Yang Zhao et al. KIDNEY INTERNATIONAL
- Solubleα-Klotho Serum Levels in Chronic Kidney Disease
- (2015) Silverio Rotondi et al. International Journal of Endocrinology
- The Fibroblast Growth Factor signaling pathway
- (2015) David M. Ornitz et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Identification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho
- (2014) Ci-Di Chen et al. BIOCHEMISTRY
- Associations of FGF-23 and sKlotho with Cardiovascular Outcomes among Patients with CKD Stages 2-4
- (2014) S. Seiler et al. Clinical Journal of the American Society of Nephrology
- Antiaging gene Klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats
- (2014) Yuhong Wang et al. JOURNAL OF HYPERTENSION
- Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling
- (2014) Xu Guan et al. JOURNAL OF PATHOLOGY
- CKD-Induced Wingless/Integration1 Inhibitors and Phosphorus Cause the CKD-Mineral and Bone Disorder
- (2014) Y. Fang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The Kidney Is the Principal Organ Mediating Klotho Effects
- (2014) K. Lindberg et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Klotho attenuates high glucose-induced fibronectin and cell hypertrophy via the ERK1/2-p38 kinase signaling pathway in renal interstitial fibroblasts
- (2014) Jau-Shyang Huang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Inflammatory processes in renal fibrosis
- (2014) Xiao-Ming Meng et al. Nature Reviews Nephrology
- The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody
- (2014) Sarah L. Barker et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Reduced Renal α-Klotho Expression in CKD Patients and Its Effect on Renal Phosphate Handling and Vitamin D Metabolism
- (2014) Hirokazu Sakan et al. PLoS One
- The Role of Klotho on Vascular Calcification and Endothelial Function in Chronic Kidney Disease
- (2014) Marc G. Vervloet et al. SEMINARS IN NEPHROLOGY
- Circulating α-Klotho Levels in CKD and Relationship to Progression
- (2013) Hyoung Rae Kim et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Chronic Kidney Disease: A Clinical Model of Premature Aging
- (2013) Peter Stenvinkel et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism
- (2013) Ming Chang Hu et al. Annual Review of Physiology
- The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD
- (2013) S. Pelletier et al. Clinical Journal of the American Society of Nephrology
- Renal Elimination of Sclerostin Increases With Declining Kidney Function
- (2013) Daniel Cejka et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling
- (2013) L. Zhou et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease
- (2013) Kristin M. McCabe et al. KIDNEY INTERNATIONAL
- Early chronic kidney disease–mineral bone disorder stimulates vascular calcification
- (2013) Yifu Fang et al. KIDNEY INTERNATIONAL
- Evolving importance of kidney disease: from subspecialty to global health burden
- (2013) Kai-Uwe Eckardt et al. LANCET
- Laboratory aspects of circulating -Klotho
- (2013) A. C. Heijboer et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Oxidative Stress and Cell Senescence Combine to Cause Maximal Renal Tubular Epithelial Cell Dysfunction and Loss in an in vitro Model of Kidney Disease
- (2013) David M. Small et al. NEPHRON EXPERIMENTAL NEPHROLOGY
- Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease
- (2013) Richard D. Semba et al. NEUROSCIENCE LETTERS
- Renal and Extrarenal Actions of Klotho
- (2013) Ming Chang Hu et al. SEMINARS IN NEPHROLOGY
- Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway
- (2012) Yuhong Wang et al. AGING CELL
- Validation of an Immunoassay for Soluble Klotho Protein
- (2012) Sridevi Devaraj et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway
- (2012) Olena Andrukhova et al. BONE
- The relationship between the soluble Klotho protein and the residual renal function among peritoneal dialysis patients
- (2012) Tetsu Akimoto et al. Clinical and Experimental Nephrology
- Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis
- (2012) Yoshiko Shimamura et al. Clinical and Experimental Nephrology
- Promoter methylation confers kidney-specific expression of the Klotho gene
- (2012) Masahiro Azuma et al. FASEB JOURNAL
- Circulating αKlotho influences phosphate handling by controlling FGF23 production
- (2012) Rosamund C. Smith et al. JOURNAL OF CLINICAL INVESTIGATION
- Calcium Deficiency Reduces Circulating Levels of FGF23
- (2012) M. E. Rodriguez-Ortiz et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet
- (2012) Wei Ling Lau et al. KIDNEY INTERNATIONAL
- Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion
- (2012) Osamu Asai et al. KIDNEY INTERNATIONAL
- Plasma Klotho is not related to kidney function and does not predict adverse outcome in patients with chronic kidney disease
- (2012) Sarah Seiler et al. KIDNEY INTERNATIONAL
- Chronic inhibition of nuclear factor kappa B attenuates aldosterone/salt-induced renal injury
- (2012) Wei Ding et al. LIFE SCIENCES
- Klotho, phosphate and inflammation/ageing in chronic kidney disease
- (2012) M. C. Izquierdo et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- The emerging role of Klotho in clinical nephrology
- (2012) Ming Chang Hu et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Secreted Klotho and FGF23 in chronic kidney disease Stage 1 to 5: a sequence suggested from a cross-sectional study
- (2012) Ivana Pavik et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Fibroblast growth factor 23 and soluble klotho in children with chronic kidney disease
- (2012) Mandy Wan et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Regulation and Function of the FGF23/Klotho Endocrine Pathways
- (2012) Aline Martin et al. PHYSIOLOGICAL REVIEWS
- Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease
- (2012) Tetsu Akimoto et al. BMC Nephrology
- Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells
- (2011) Ryan E. Forster et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate
- (2011) Catherine M. Shanahan et al. CIRCULATION RESEARCH
- Circulating levels of soluble α-Klotho in patients with chronic kidney disease
- (2011) Hidekazu Sugiura et al. Clinical and Experimental Nephrology
- Soluble Klotho and Autosomal Dominant Polycystic Kidney Disease
- (2011) I. Pavik et al. Clinical Journal of the American Society of Nephrology
- Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation
- (2011) Y. Zhao et al. DIABETES
- Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice
- (2011) Shigehiro Doi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Inflammatory Cytokines TWEAK and TNF Reduce Renal Klotho Expression through NF B
- (2011) J. A. Moreno et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
- (2011) Howard Trachtman et al. KIDNEY INTERNATIONAL
- Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
- (2011) Tamara Isakova et al. KIDNEY INTERNATIONAL
- Klotho suppresses RIG-I-mediated senescence-associated inflammation
- (2011) Feng Liu et al. NATURE CELL BIOLOGY
- Cellular and molecular mechanisms of renal fibrosis
- (2011) Youhua Liu Nature Reviews Nephrology
- The role of collagen metabolism in CKD-associated arterial senescence: underestimated and underappreciated
- (2011) F. Verbeke et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects
- (2010) Yuji Yamazaki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
- (2010) Ming Chang Hu et al. FASEB JOURNAL
- Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease
- (2010) M. C. Hu et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective
- (2010) Ming-Chang Hu et al. KIDNEY INTERNATIONAL
- Treatment with pyrophosphate inhibits uremic vascular calcification
- (2010) W Charles O'Neill et al. KIDNEY INTERNATIONAL
- Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
- (2010) H. E. Yoon et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Relation Between Alkaline Phosphatase, Serum Phosphate, and All-Cause or Cardiovascular Mortality
- (2009) Marcello Tonelli et al. CIRCULATION
- Klotho is a substrate for α-, β- and γ-secretase
- (2009) Laura Bloch et al. FEBS LETTERS
- Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways
- (2009) Fuye Yang et al. HYPERTENSION
- Pulse wave velocity and vascular calcification at different stages of chronic kidney disease
- (2009) Mohamed Temmar et al. JOURNAL OF HYPERTENSION
- Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis
- (2009) W. He et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The emerging role of phosphate in vascular calcification
- (2009) Cecilia M. Giachelli KIDNEY INTERNATIONAL
- PPAR-γ and aging: one link through klotho?
- (2008) Ruihua Zhang et al. KIDNEY INTERNATIONAL
- Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
- (2008) S.-K. Cha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now