Circulating αKlotho influences phosphate handling by controlling FGF23 production

FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone

(2011) Simon Wöhrle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

(2011) E. G. Farrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation

(2010) Emily G Farrow et al.   JOURNAL OF ENDOCRINOLOGY

Initial FGF23-Mediated Signaling Occurs in the Distal Convoluted Tubule

(2009) E. G. Farrow et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis

(2008) Damian Medici et al.   JOURNAL OF CELL BIOLOGY

A translocation causing increased  -Klotho level results in hypophosphatemic rickets and hyperparathyroidism

(2008) C. A. Brownstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY