Article
Medicine, General & Internal
Jin Yao, Zheyi Dong, Qian Wang, Zhe Li, Weiguang Zhang, Wenwen Lin, Yayong Luo, Hangtian Li, Xinru Guo, Li Zhang, Guangyan Cai, Wanjun Shen, Shuwei Duan, Xiangmei Chen
Summary: This study found that in patients with chronic kidney disease (CKD), factors such as female sex, age, smoking, mean arterial pressure (MAP), glomerular filtration rate (eGFR), cause of disease, ACEI/ARB, and glucocorticoid were associated with arterial stiffness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Monika Drozdz, Anna Moczulska, Andrzej Rudzinski, Dorota Drozdz
Summary: This study aimed to identify the most significant risk factors of left ventricular hypertrophy (LVH) in children with chronic kidney disease (CKD). The results showed that metabolic syndrome, hypertension, and CKD stage were the most important risk factors for LVH.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Balazs Sagi, Istvan Kesoi, Tibor Vas, Botond Csiky, Judit Nagy, Tibor Jozsef Kovacs
Summary: This study suggests that increased cardiac and vascular stiffness coexist with decreased renal function in chronic kidney disease, which is directly associated with diastolic dysfunction and vascular stiffness. Vascular alterations in very early CKD can be identified by comparing the CKD group to the control group.
Article
Urology & Nephrology
Takahiro Imaizumi, Naohiko Fujii, Takayuki Hamano, Wei Yang, Masataka Taguri, Mayank Kansal, Rupal Mehta, Tariq Shafi, Jonathan Taliercio, Alan Go, Panduranga Rao, L. Lee Hamm, Rajat Deo, Shoichi Maruyama, Masafumi Fukagawa, Harold I. Feldman
Summary: It has been found that patients receiving dialysis therapy in the United States are more prone to cardiovascular disease (CVD) compared to those in Japan. Left ventricular mass index (LVMI) and ejection fraction (EF) showed significant differences between the two cohorts, and low EF and high LVMI were significantly associated with subsequent CVD in both groups. The higher LV mass and lower EF, even within the normal range, were found to be predictive of CVD in chronic kidney disease (CKD) patients.
KIDNEY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Caifeng Shi, Aiqin He, Xiaomei Wu, Lulu Wang, Xueting Zhu, Lei Jiang, Junwei Yang, Yang Zhou
Summary: The urinary levels of IL-18 appear to be associated with greater pulse wave velocity (PWV) in patients with T2D, indicating a link between urinary IL-18 and arterial stiffness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Xiangdong Wang, Dongpo Zhu, Leilei Peng, Yan Gao, Xiaodong Li
Summary: By analyzing clinical parameters and laboratory tests, we found that body mass index (BMI), low-density lipoprotein (LDL), and 24-hour urine proteins have a significant impact on left ventricular hypertrophy (LVH) in patients with diabetic kidney disease (DKD). We also determined the optimal cutoff values for BMI, LDL, and 24-hour urine proteins. Therefore, these factors can serve as independent risk factors for LVH in patients with DKD.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Douglas Mesadri Gewehr, Allan Fernando Giovanini, Beatriz Alvarez Mattar, Anelyse Pulner Agulham, Andressa de Souza Bertoldi, Seigo Nagashima, Fernando Bermudez Kubrusly, Luiz Fernando Kubrusly
Summary: This study aimed to establish a rat model of congestive hepatopathy (CH) secondary to right ventricular hypertrophy (RVH) induced by monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). The rat model showed nutmeg-like liver appearance, marked RVH, dilation, and fibrosis. The model was reproducible, safe, and effectively induced CH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Transplantation
Natasha J. McIntyre, Adam Shardlow, Richard J. Fluck, Christopher W. McIntyre, Maarten W. Taal
Summary: This study observed a clinically significant increase in PWV over 5 years in a cohort of elderly patients with early CKD, despite well-controlled hypertension. Blood pressure measurements were identified as the most important modifiable determinant of Delta PWV, suggesting interventions for preventing arterial disease should mainly focus on improving blood pressure control.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Chaojie Ye, Lijie Kong, Zhiyun Zhao, Mian Li, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Yuhong Chen, Yiping Xu, Weiqing Wang, Guang Ning, Yufang Bi, Min Xu, Tiange Wang
Summary: This study, using mendelian randomization analysis, found causal relations between obesity and chronic kidney disease (CKD) and arterial stiffness. The findings highlight the importance of weight management for the prevention and control of subclinical vascular diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Peripheral Vascular Disease
Ioannis Goulas, Kleo Evripidou, Ioannis Doundoulakis, Konstantinos Kollios, Thomai Nika, Athanasia Chainoglou, Vasilios Kotsis, Stella Stabouli
Summary: Limited studies have been conducted on the assessment of blood pressure status in young patients with CKD on dialysis or after kidney transplantation using ABPM. This meta-analysis found a high prevalence of masked hypertension and left ventricular hypertrophy in children and young adults with CKD on dialysis or after kidney transplantation. Therefore, ABPM and echocardiography play a crucial role in assessing BP status and cardiovascular risk in this population.
JOURNAL OF HYPERTENSION
(2023)
Article
Physiology
Catherine Fortier, Charles-Antoine Garneau, Mathilde Pare, Hasan Obeid, Nadege Cote, Karine Duval, Remi Goupil, Mohsen Agharazii
Summary: The acute administration of nitroglycerin leads to a significant reduction in pulse wave velocity of muscular arteries without affecting aortic pulse wave velocity. This results in an unfavorable change in the AB-PWV and AF-PWV ratios, potentially increasing pulse pressure transmission into the microcirculation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shun Matsumura, Catherine D'Addiaro, Orazio J. Slivano, Carmen De Miguel, Charles Stier, Rakhee Gupte, Joseph M. Miano, Sachin A. Gupte
Summary: Individuals with G6PD deficiency in the Mediterranean region have lower susceptibility to cardiovascular diseases, but the effect on vascular inflammation and arterial stiffness is limited.
VASCULAR PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michinari Hieda, Satyam Sarma, Christopher M. Hearon, James P. MacNamara, Katrin A. Dias, Mitchel Samels, Dean Palmer, Sheryl Livingston, Margot Morris, Benjamin D. Levine
Summary: The study suggests that high-intensity exercise training can reduce LV myocardial stiffness in patients with LV hypertrophy, thus helping to prevent the development of heart failure.
Article
Urology & Nephrology
Ruyi Cai, Lina Shao, Yifan Zhu, Yueming Liu, Jinshi Zhang, Qiang He
Summary: The study found that central pulse pressure (CPP) is a better predictor of left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD) compared to brachial pulse pressure. This suggests that central arterial blood pressure may be a more reliable indicator of LVH in CKD patients, similar to the general population.
Article
Medicine, General & Internal
Dimitra Bacharaki, Ioannis Petrakis, Periklis Kyriazis, Anastasia Markaki, Christos Pleros, Georgios Tsirpanlis, Marios Theodoridis, Olga Balafa, Anastasia Georgoulidou, Eleni Drosataki, Kostas Stylianou
Summary: Adherence to a Mediterranean-style diet has a positive impact on the cardiovascular health of chronic kidney disease patients on dialysis, reducing the occurrence of left ventricular hypertrophy and abnormal cardiac geometry. This is of significant importance in managing the risk of cardiovascular disease in dialysis patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
