Review
Pharmacology & Pharmacy
Haseeb Ahsan, Salman Ul Islam, Muhammad Bilal Ahmed, Young Sup Lee
Summary: Cancer is a complex disease that can be prevented or suppressed through chemoprevention. Targeting molecules such as Nrf2, STAT3, and Src, which are involved in various pathways of cancer, can reduce oxidative stress and inflammation and stop cancer initiation and progression.
Review
Pharmacology & Pharmacy
Mingshun Zuo, Hongchuan Chen, Yuanjian Liao, Pingang He, Te Xu, Jiajia Tang, Neng Zhang
Summary: Bladder cancer is a common tumor with increasing incidence. Sulforaphane, a compound found in cruciferous plants, has shown promising anticancer effects against bladder cancer. It can inhibit the growth and metastasis of bladder cancer cells, as well as target bladder cancer stem cells through various molecular pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Runyi Ye, Dongwei Liu, Hongyu Guan, NiJiati AiErken, Zeng Fang, Yawei Shi, Yunjian Zhang, Shenming Wang
Summary: The study showed that upregulation of AHNAK2 in thyroid carcinoma tissues, especially in metastatic ones, is associated with poor prognosis. Knockdown of AHNAK2 inhibited thyroid carcinoma migration, invasion, and metastasis by reducing activation of the NF-kappa B pathway. This provides a novel target for treating metastatic thyroid carcinoma.
Article
Pharmacology & Pharmacy
Dan Huang, Chaoqun Sun, Min Chen, Shuyou Bai, Xuanna Zhao, Weiming Wang, Kang Geng, Wenbo Huang, Tingting Zhao, Bin Wu, Guilin Zhang, Dong Wu, Youhua Xu
Summary: This study found that the SIRT1 agonist bergenin can improve asthma-induced airway inflammation and remodeling by activating SIRT1 and regulating the transcriptional activity of nuclear factor kappa B.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hexu Han, Ting Lin, Zhenyu Wang, Jingjing Song, Ziyi Fang, Jing Zhang, Xiaomin You, Yanping Du, Jun Ye, Guoxiong Zhou
Summary: The study investigated the role of RNA-binding motif 4 (RBM4) in angiogenesis in hepatocellular carcinoma (HCC). It was found that RBM4 expression was correlated with tumor microvessel density and the expression of proangiogenic factor VEGF-A. Mechanistically, RBM4 mediated its effects through the NF-kB signaling pathway. These findings suggest that RBM4 plays a crucial role in promoting angiogenesis in HCC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Reham I. Alagal, Nora A. AlFaris, Ghedeir M. Alshammari, Jozaa Z. ALTamimi, Lujain A. AlMousa, Mohammed Abdo Yahya
Summary: This study demonstrates that kaempferol protects the structure and function of the kidneys in doxorubicin-treated rats by upregulating and activating SIRT1, thereby alleviating doxorubicin-induced nephropathy.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Allergy
Roshini S. Abraham, Joanna M. Marshall, Hye Sun Kuehn, Cesar M. Rueda, Amber Gibbs, Will Guider, Claire Stewart, Sergio D. Rosenzweig, Huanyu Wang, Sophonie Jean, Mark Peeples, Tiffany King, W. Garrett Hunt, Jonathan R. Honegger, Octavio Ramilo, Peter J. Mustillo, Asuncion Mejias, Monica Ardura, Masako Shimamura
Summary: COVID-19, caused by SARS-CoV-2, can have a significant impact on the immune system. This study evaluated a novel NFKB2 loss of function variant in a 17-year-old male patient and discussed the clinical management of SARS-CoV-2 infection in this context. Despite underlying immune dysfunction, the patient recovered from the infection with intense management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhenfei Ding, Ce Dai, Wenshan Shan, Rui Liu, Wei Lu, Weilu Gao, Hui Zhang, Wei Huang, Jianzhong Guan, Zongsheng Yin
Summary: Under inflammatory conditions, TNF-alpha activates Nanog expression in astrocytes through the NF-kappa B signaling pathway, leading to their dedifferentiation and acquisition of stem cell-like characteristics.
Article
Biochemistry & Molecular Biology
Yingming Sun, Xiaoge Sun, Chengcheng You, Shijing Ma, Yuan Luo, Shan Peng, Fang Tang, Xiaoli Tian, Feng Wang, Zhengrong Huang, Hongnv Yu, Yu Xiao, Xiaoyong Wang, Junhong Zhang, Yan Gong, Conghua Xie
Summary: MUC3A is highly expressed in non-small cell lung cancer (NSCLC) and associated with poor prognosis, advanced staging, and low differentiation. Knockdown of MUC3A suppresses tumor growth and DNA damage repair pathways, suggesting it may be a potential oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yingchao Gong, Qingfeng Li, Zetao Ma, Tingting Jin, Jun Lin, Qingbo Lv, Meihui Wang, Guosheng Fu, Shengjie Xu
Summary: The study revealed elevated levels of LPC in atherosclerotic patients, with LPC stimulation leading to increased secretion of inflammatory factors in HUVECs through activation of ER stress and the NF-kappa B pathway. This suggests that targeting ATF4 could be a potential treatment strategy for atherosclerosis by suppressing UPR and inhibiting inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mengyuan Li, Yueyang Liu, Xueyi Nie, Boli Ma, Yabo Ma, Yuxin Hou, Yi Yang, Jinrui Xu, Yujiong Wang
Summary: The study found that S100A4 and GSDMD were significantly up-regulated in the peripheral blood of patients with pulmonary tuberculosis, and S100A4 promotes macrophage pyroptosis induced by Mycobacterium tuberculosis infection through activation of the NF-κB/NLRP3 inflammasome signaling pathway. These findings provide new insights into the role of S100A4 in Mycobacterium tuberculosis-induced macrophage pyroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chao Zhu, Wei Chen, Haiming Cui, Zhigang Huang, Ru Ding, Na Li, Qinqin Wang, Feng Wu, Yanmin Zhao, Xiaoliang Cong
Summary: Oxidized low-density lipoprotein (ox-LDL) promotes the expression of TRIM64, enhancing the activation of NLRP3 inflammasomes and the expression of downstream molecules. TRIM64 interacts with I kappa B alpha, promoting I kappa B alpha ubiquitination to activate the NF-kappa B signaling pathway. TRIM64 and NF-kappa B form a positive feedback mechanism in the development of atherosclerosis.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shenglan Liu, Liangmei He, Junhong Wu, Xinqiang Wu, Lu Xie, Wei Dai, Lingxia Chen, Fuhua Xie, Zhiping Liu
Summary: DHX9 plays a crucial role in promoting proliferation and metastasis in colorectal cancer, making it a potential therapeutic target for prevention and treatment of CRC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xin Yang, Maodi Liang, Yihan Tang, Dingling Ma, Menghuan Li, Chenggang Yuan, Yanting Hou, Chaoyue Sun, Jie Liu, Qianqian Wei, Yongsheng Chang, Cuizhe Wang, Jun Zhang
Summary: In the context of obesity, inflammatory cytokines secreted by adipocytes contribute to insulin resistance and play a key role in the development of metabolic syndrome. Our previous study found that the transcription factor KLF7 promotes the expression of p-p65 and IL-6 in adipocytes, but the specific molecular mechanism remains unclear. In this study, we found that the expression of KLF7, PKC?, p-I?B, p-p65, and IL-6 was significantly increased in epididymal white adipose tissue (Epi WAT) of mice fed a high-fat diet (HFD). However, in KLF7 fat conditional knockout mice, the expression of PKC?, p-I?B, p-p65, and IL-6 was significantly decreased in Epi WAT. In 3T3-L1 adipocytes, KLF7 promotes the expression of IL-6 through the PKC?/NF-?B pathway. Furthermore, luciferase reporter and chromatin immunoprecipitation assays confirmed that KLF7 upregulates the expression of PKC? transcripts in HEK-293T cells. Together, our results demonstrate that KLF7 promotes the expression of IL-6 by upregulating PKC? expression and activating the NF-?B signaling pathway in adipocytes.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.