E-Cadherin/β-Catenin Complex: A Target for Anticancer and Antimetastasis Plants/Plant-derived Compounds

The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice

(2016) Srithar Gunaseelan et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

In vitro bioavailability and cellular bioactivity studies of flavonoids and flavonoid-rich plant extracts: questions, considerations and future perspectives

(2016) Gerard Bryan Gonzales   PROCEEDINGS OF THE NUTRITION SOCIETY

Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors

(2015) Xujuan Yang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance

(2015) Chia-Hung Liu et al.   International Journal of Medical Sciences

Diallyl disulfide inhibits growth and metastatic potential of human triple-negative breast cancer cells through inactivation of the β-catenin signaling pathway

(2015) Jing Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Properties of Resveratrol:In VitroandIn VivoStudies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans

(2015) J. Gambini et al.   Oxidative Medicine and Cellular Longevity

Plant derived substances with anti-cancer activity: from folklore to practice

(2015) Marcelo Fridlender et al.   Frontiers in Plant Science

Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

(2014) Majid Tafrihi et al.   Asian Pacific Journal of Cancer Prevention

Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review

(2014) Ashok Kumar Pandurangan et al.   Asian Pacific Journal of Cancer Prevention

Green tea polyphenol EGCG suppresses Wnt/β-catenin signaling by promoting GSK-3β- and PP2A-independent β-catenin phosphorylation/degradation

(2014) Sangtaek Oh et al.   BIOFACTORS

Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer

(2014) Myung Ah Lee et al.   BMC CANCER

Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling

(2014) Andreas Herbst et al.   BMC GENOMICS

Overexpression of cytoplasmic β-catenin inhibits the metastasis of the murine osteosarcoma cell line LM8

(2014) Teruki Kidani et al.   Cancer Cell International

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

(2014) D. Raha et al.   CANCER RESEARCH

Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis

(2014) AK Pandurangan et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo

(2014) Maryam Sartippour et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Isoquercitrin Suppresses Colon Cancer Cell Growthin Vitroby Targeting the Wnt/β-Catenin Signaling Pathway

(2014) Nathália G. Amado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model

(2014) Juan E. Andrade et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antitumorigenic Potential of Linalool Is Accompanied by Modulation of Oxidative Stress: An In Vivo Study in Sarcoma-180 Solid Tumor Model

(2014) Samarjit Jana et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Advances in understanding the interrelations between leptin resistance and obesity

(2014) Haitao Pan et al.   PHYSIOLOGY & BEHAVIOR

Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways

(2014) Harish Chandra Pal et al.   PLoS One

Capsaicin Treatment Attenuates Cholangiocarcinoma Carcinogenesis

(2014) Annika Wutka et al.   PLoS One

β-catenin C429S mice exhibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia

(2014) Takuya Murata et al.   Scientific Reports

Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop

(2014) Shravanti Mukherjee et al.   Stem Cell Research & Therapy

Epithelial-Mesenchymal Transition Markers in the Differential Diagnosis of Gastroenteropancreatic Neuroendocrine Tumors

(2013) Jose A. Galván et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22

(2013) Hailin Tang et al.   CANCER LETTERS

A Role for Matrix Metalloproteinases in Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway

(2013) Kai Kessenbrock et al.   Cell Stem Cell

Looking beyond the Wnt pathway for the deep nature of β-catenin

(2013) François Fagotto   EMBO REPORTS

Emodin represses TWIST1-induced epithelial–mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways

(2013) Tzong-Der Way et al.   EUROPEAN JOURNAL OF CANCER

Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells

(2013) Sílvia Cufí et al.   FOOD AND CHEMICAL TOXICOLOGY

Pharmacological modulation of beta-catenin and its applications in cancer therapy

(2013) Ravi Thakur et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

(2013) Junfang Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Luteolin Induces Growth Arrest in Colon Cancer Cells Through Involvement of Wnt/β-Catenin/GSK-3β Signaling

(2013) Ashok Kumar Pandurangan et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Synthesis, characterization, and evaluation of a novel inhibitor of WNT/β-catenin signaling pathway

(2013) Zhao Yan et al.   Molecular Cancer

Silymarin suppresses the PGE2-induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways

(2013) Seon Min Woo et al.   MOLECULAR CARCINOGENESIS

The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling

(2013) Rohinton S. Tarapore et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases

(2013) Andrea Tarozzi et al.   Oxidative Medicine and Cellular Longevity

Mammosphere Formation in Breast Carcinoma Cell Lines Depends upon Expression of E-cadherin

(2013) Juan Manuel Iglesias et al.   PLoS One

Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway

(2013) Qing Ji et al.   PLoS One

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-Catenin Signaling Pathway Upregulates c-Myc Expression to Promote Cell Proliferation of P19 Teratocarcinoma Cells

(2012) Shuai Zhang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME

(2012) Zhen Yang et al.   Anti-Cancer Agents in Medicinal Chemistry

The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway

(2012) Hui-Jye Chen et al.   BIOCHEMICAL PHARMACOLOGY

Fragrant environment with α-pinene decreases tumor growth in mice

(2012) Masatoshi Kusuhara et al.   BIOMEDICAL RESEARCH-TOKYO

Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia

(2012) Stephany Corrêa et al.   BMC CANCER

Genistein inhibits cell invasion and motility by inducing cell differentiation in murine osteosarcoma cell line LM8

(2012) Atsushi Nakamura et al.   BMC CELL BIOLOGY

Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice

(2012) M. Du et al.   CARCINOGENESIS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells

(2012) Yujuan Shan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Garlic Derivative, S-allylcysteine (SAC), Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma

(2012) Kevin T. P. Ng et al.   PLoS One

WNT/β-Catenin-Signaling Pathway Stimulates the Proliferation of Cultured Adult Human Sertoli Cells via Upregulation of C-myc Expression

(2012) Yi Li et al.   Reproductive Sciences

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

(2012) Marc de la Roche et al.   Nature Communications

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide

(2011) Dalia Hussein El-Rouby   ARCHIVES OF ORAL BIOLOGY

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

(2011) Seung Joon Lee et al.   BMC CANCER

Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?

(2011) R E Langley et al.   BRITISH JOURNAL OF CANCER

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

(2011) Ethan B Russo   BRITISH JOURNAL OF PHARMACOLOGY

Role of E-cadherin in Antimigratory and Antiinvasive Efficacy of Silibinin in Prostate Cancer Cells

(2011) G. Deep et al.   Cancer Prevention Research

Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth

(2011) J. Waaler et al.   CANCER RESEARCH

A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis

(2011) Wei Wang et al.   CELL RESEARCH

Ellagic acid coordinately attenuates Wnt/β-catenin and NF-κB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis

(2011) Prabukumar Anitha et al.   EUROPEAN JOURNAL OF NUTRITION

Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells

(2011) Lei Wang et al.   Integrative Biology

Teucrium Plant Species as Natural Sources of Novel Anticancer Compounds: Antiproliferative, Proapoptotic and Antioxidant Properties

(2011) Milan S. Stankovic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Consumption of Lycopene Inhibits the Growth and Progression of Colon Cancer in a Mouse Xenograft Model

(2011) Feng-Yao Tang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Matrix Metalloproteinase (MMP)-9 Induced by Wnt Signaling Increases the Proliferation and Migration of Embryonic Neural Stem Cells at Low O2Levels

(2011) Christopher A. Ingraham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling

(2011) Buzz Baum et al.   JOURNAL OF CELL BIOLOGY

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells

(2011) Seong-Ho Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice

(2011) Kristoffer W Brudvik et al.   Molecular Cancer

Aberrant activation of Wnt/β-catenin signaling pathway contributes to the sequential progression of DMBA-induced HBP carcinomas

(2011) Ramamurthi Vidya Priyadarsini et al.   ORAL ONCOLOGY

Resveratrol Inhibits Pancreatic Cancer Stem Cell Characteristics in Human and KrasG12D Transgenic Mice by Inhibiting Pluripotency Maintaining Factors and Epithelial-Mesenchymal Transition

(2011) Sharmila Shankar et al.   PLoS One

Multiple Wnt/ß-Catenin Responsive Enhancers Align with the MYC Promoter through Long-Range Chromatin Loops

(2011) Gregory S. Yochum   PLoS One

A Positive Role of Cadherin in Wnt/β-Catenin Signalling during Epithelial-Mesenchymal Transition

(2011) Sara Howard et al.   PLoS One

Inhibition of N-linked glycosylation by tunicamycin induces E-cadherin-mediated cell–cell adhesion and inhibits cell proliferation in undifferentiated human colon cancer cells

(2010) Julio Cesar Madureira de Freitas Junior et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

(2010) Y. Li et al.   CLINICAL CANCER RESEARCH

Formation of extra centrosomal structures is dependent on  -catenin

(2010) S. Bahmanyar et al.   JOURNAL OF CELL SCIENCE

Clinical characteristics of TIMP2, MMP2, and MMP9 gene polymorphisms in colorectal cancer

(2010) Kyung Sook Park et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Tetrandrine Inhibits Wnt/ -Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer

(2010) B.-C. He et al.   MOLECULAR PHARMACOLOGY

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors

(2010) He   ONCOLOGY REPORTS

The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells

(2010) Irene Ma et al.   Stem Cell Reviews and Reports

Curcumin derivatives: Molecular basis of their anti-cancer activity

(2009) Valentina Basile et al.   BIOCHEMICAL PHARMACOLOGY

Genistein synergizes with RNA interference inhibiting survivin for inducing DU-145 of prostate cancer cells to apoptosis

(2009) Fan Yuan-jing et al.   CANCER LETTERS

Lupeol inhibits proliferation of human prostate cancer cells by targeting  -catenin signaling

(2009) M. Saleem et al.   CARCINOGENESIS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

(2009) Johannes von Burstin et al.   GASTROENTEROLOGY

Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion

(2009) Meghan T. Maher et al.   JOURNAL OF CELL BIOLOGY

Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex

(2009) Mustapha Kandouz et al.   JOURNAL OF ETHNOPHARMACOLOGY

Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin

(2009) Q. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

Lycopene Effects Contributing to Prostate Health

(2009) Karin Wertz   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Involvement of Members of the Cadherin Superfamily in Cancer

(2009) G. Berx et al.   Cold Spring Harbor Perspectives in Biology

Adherens Junction: Molecular Architecture and Regulation

(2009) W. Meng et al.   Cold Spring Harbor Perspectives in Biology

A novel anti-cancer effect of genistein: reversal of epithelial mesenchymal transition in prostate cancer cells1

(2008) Lin-lin ZHANG et al.   ACTA PHARMACOLOGICA SINICA

Multi-targeted prevention of cancer by sulforaphane

(2008) John D. Clarke et al.   CANCER LETTERS

Indole-3-carbinol as a chemopreventive and anti-cancer agent

(2008) Jing-Ru Weng et al.   CANCER LETTERS

Garlic Constituent Diallyl Trisulfide Prevents Development of Poorly Differentiated Prostate Cancer and Pulmonary Metastasis Multiplicity in TRAMP Mice

(2008) S. V. Singh et al.   CANCER RESEARCH

Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1

(2008) H.-W. Chen et al.   CANCER RESEARCH

Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter

(2008) H. Nian et al.   CARCINOGENESIS

Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates  -catenin signaling in mammary epithelial cells

(2008) Y. Su et al.   CARCINOGENESIS

A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF- B-signaling pathways

(2008) Y. Suh et al.   CARCINOGENESIS

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

The cell-cell adhesion molecule E-cadherin

(2008) F. van Roy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel anticancer effect of butein: Inhibition of invasion through the ERK1/2 and NF-κB signaling pathways in bladder cancer cells

(2008) LiRui Zhang et al.   FEBS LETTERS

Broccoli flower head extract reduces mitomycin-C induced sister chromatid exchange in cultured human lymphocytes

(2008) M. Anupama et al.   FOOD AND CHEMICAL TOXICOLOGY

Phytochemical composition, anti-inflammatory and antitumour activities of four Teucrium essential oils from Greece

(2008) Federica Menichini et al.   FOOD CHEMISTRY

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Correlation between β-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma

(2008) Madeleine Austinat et al.   Molecular Cancer

Anticancer Effects of the Chinese Medicine Matrine on Murine Hepatocellular Carcinoma Cells

(2008) Lingdi Ma et al.   PLANTA MEDICA

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY

-Catenin is a Nek2 substrate involved in centrosome separation

(2007) S. Bahmanyar et al.   GENES & DEVELOPMENT