Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study

Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction

(2017) Chia-Ming Liu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer

(2016) María Ángeles Núñez-Sánchez et al.   FOOD AND CHEMICAL TOXICOLOGY

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks inex vivoculture

(2016) Fanny Grillet et al.   GUT

Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models

(2016) Vítor E. Santo et al.   JOURNAL OF BIOTECHNOLOGY

Recovery of antioxidant and antiproliferative compounds from watercress using pressurized fluid extraction

(2016) Liliana Rodrigues et al.   RSC Advances

Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications

(2016) Huai-Qiang Ju et al.   Theranostics

Circulating Tumor Cell Count Correlates with Colorectal Neoplasm Progression and Is a Prognostic Marker for Distant Metastasis in Non-Metastatic Patients

(2016) Wen-Sy Tsai et al.   Scientific Reports

The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment

(2015) Francesca Pistollato et al.   FOOD AND CHEMICAL TOXICOLOGY

Sasa quelpaertensis Leaf Extract Inhibits Colon Cancer by Regulating Cancer Cell Stemness in Vitro and in Vivo

(2015) Soo Min et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells

(2015) DONG HWAN KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Sulforaphane down-regulates SKP2 to stabilize p27KIP1 for inducing antiproliferation in human colon adenocarcinoma cells

(2015) Yuan-Kai Chung et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Metabolism and antiproliferative effects of sulforaphane and broccoli sprouts in human intestinal (Caco-2) and hepatic (HepG2) cells

(2015) Nieves Baenas et al.   PHYTOCHEMISTRY REVIEWS

Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol

(2015) G. Cano-Sancho et al.   TOXICOLOGY IN VITRO

Dual Effects Exerted in Vitro by Micromolar Concentrations of Deoxynivalenol on Undifferentiated Caco-2 Cells

(2015) Gina Manda et al.   Toxins

Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing

(2015) Xue Gong et al.   PLoS One

Cancer stem cells

(2014) Susan D. Mertins   ANTI-CANCER DRUGS

Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells

(2014) Dan Wang et al.   BMC CANCER

Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations

(2014) Yao-Tsung Yeh et al.   FREE RADICAL BIOLOGY AND MEDICINE

LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells

(2014) XIANG CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells

(2014) SABRINA LABSCH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Correction: Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy

(2014) Scott J. Dylla et al.   PLoS One

Construction and characteristics of an E-cadherin-related three-dimensional suspension growth model of ovarian cancer

(2014) Shan Xu et al.   Scientific Reports

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

(2013) Paola Longati et al.   BMC CANCER

LGR5 positivity defines stem-like cells in colorectal cancer

(2013) Daniela Hirsch et al.   CARCINOGENESIS

Wnt signaling in adult intestinal stem cells and cancer

(2013) Michaela Krausova et al.   CELLULAR SIGNALLING

Technologies for Extraction and Production of Bioactive Compounds to be Used as Nutraceuticals and Food Ingredients: An Overview

(2013) G. Joana Gil-Chávez et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

(2013) Praveen Rajendran et al.   Epigenetics

Differential effects of polyphenols-enriched extracts from hawthorn fruit peels and fleshes on cell cycle and apoptosis in human MCF-7 breast carcinoma cells

(2013) Ting Li et al.   FOOD CHEMISTRY

Evaluation of Opuntia spp. derived products as antiproliferative agents in human colon cancer cell line (HT29)

(2013) Ana Teresa Serra et al.   FOOD RESEARCH INTERNATIONAL

Postoperative Detection of Circulating Tumor Cells Predicts Tumor Recurrence in Colorectal Cancer Patients

(2013) Gennaro Galizia et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Phenethylisothiocyanate Alters Site- and Promoter-Specific Histone Tail Modifications in Cancer Cells

(2013) Yi Liu et al.   PLoS One

Mammosphere Formation in Breast Carcinoma Cell Lines Depends upon Expression of E-cadherin

(2013) Juan Manuel Iglesias et al.   PLoS One

Expression of aldehyde dehydrogenase 1 in colon cancer

(2013) Yi Hou et al.   Asian Pacific Journal of Tropical Medicine

Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies

(2012) Q. J. Wu et al.   ANNALS OF ONCOLOGY

CD133+CXCR4+ colon cancer cells exhibit metastatic potential and predict poor prognosis of patients

(2012) Shan-shan Zhang et al.   BMC Medicine

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

The multicellular tumor spheroid model for high-throughput cancer drug discovery

(2012) Daniel V LaBarbera et al.   Expert Opinion on Drug Discovery

A novel function for Cyclin A2: Control of cell invasion via RhoA signaling

(2012) Nikola Arsic et al.   JOURNAL OF CELL BIOLOGY

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity

(2012) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of colorectal cancer metastasis by nigericin through inhibition of epithelial-mesenchymal transition

(2012) Hou-Min Zhou   WORLD JOURNAL OF GASTROENTEROLOGY

Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane

(2011) Ming-Jenn Chen et al.   Evidence-based Complementary and Alternative Medicine

Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic

(2011) Chang-Lin Wu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

(2011) M. L. Angus-Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer

(2011) J. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

(2010) Y. Li et al.   CLINICAL CANCER RESEARCH

Supercritical fluid extraction of lipids from broccoli leaves

(2010) Esther Arnáiz et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Phenethyl Isothiocyanate Inhibited Tumor Migration and Invasion via Suppressing Multiple Signal Transduction Pathways in Human Colon Cancer HT29 Cells

(2010) Kuang-Chi Lai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres

(2010) Shailender S Kanwar et al.   Molecular Cancer

Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate

(2010) Georgios Kallifatidis et al.   MOLECULAR THERAPY

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Cancer Chemoprevention by Natural Products: How Far Have We Come?

(2010) Rajendra G. Mehta et al.   PHARMACEUTICAL RESEARCH

The Stem Cell Marker CD133 Associates with Enhanced Colony Formation and Cell Motility in Colorectal Cancer

(2010) Tarek M. A. Elsaba et al.   PLoS One

Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies

(2009) Siew-Min Ong et al.   BIOMATERIALS

ABC transporters and isothiocyanates: potential for pharmacokinetic diet-drug interactions

(2009) Urvi Telang et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Anchorage-independent cell growth signature identifies tumors with metastatic potential

(2009) S Mori et al.   ONCOGENE

PEITC Induces G1 Cell Cycle Arrest on HT-29 Cells Through the Activation of p38 MAPK Signaling Pathway

(2008) Ka Lung Cheung et al.   AAPS Journal

Anoikis resistance and tumor metastasis

(2008) Craig D. Simpson et al.   CANCER LETTERS

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants

(2008) A. Restle et al.   NUCLEIC ACIDS RESEARCH

A genome-wide RNAi screen for Wnt/ -catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

(2008) W. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA