Hydroxytyrosol Exerts Anti-Inflammatory and Anti-Oxidant Activities in a Mouse Model of Systemic Inflammation

Oxidative DNA Damage Is Prevented by Extracts of Olive Oil, Hydroxytyrosol, and Other Olive Phenolic Compounds in Human Blood Mononuclear Cells and HL60 Cells

(2018) Roberto Fabiani et al.   JOURNAL OF NUTRITION

Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

(2017) Elisabetta Bigagli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hydroxytyrosol and Cytoprotection: A Projection for Clinical Interventions

(2017) Francisca Echeverría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant Effects of a Hydroxytyrosol-Based Pharmaceutical Formulation on Body Composition, Metabolic State, and Gene Expression: A Randomized Double-Blinded, Placebo-Controlled Crossover Trial

(2017) Carmela Colica et al.   Oxidative Medicine and Cellular Longevity

Hydroxytyrosol exerts an anti-inflammatory effect by suppressing Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus -induced mastitis in mice

(2017) Haichong Wu et al.   Journal of Functional Foods

Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation

(2017) Rodrigo Valenzuela et al.   Food & Function

Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial

(2016) Stacey Lockyer et al.   EUROPEAN JOURNAL OF NUTRITION

Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans

(2016) Stefania Rigacci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High Risk of Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Randomized Controlled Trial

(2016) Rosa Casas et al.   JOURNAL OF NUTRITION

Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

(2016) Joao Tomé-Carneiro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Olive oil compounds inhibit the paracrine regulation of TNF-α-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression

(2016) Sylvie Lamy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Matrine Attenuates COX-2 and ICAM-1 Expressions in Human Lung Epithelial Cells and Prevents Acute Lung Injury in LPS-Induced Mice

(2016) Chian-Jiun Liou et al.   MEDIATORS OF INFLAMMATION

Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones

(2016) Aya Umeno et al.   MOLECULES

Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence

(2016) Joao Tomé-Carneiro et al.   PHYTOMEDICINE

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Virgin olive oil: a key food for cardiovascular risk protection

(2015) María-Isabel Covas et al.   BRITISH JOURNAL OF NUTRITION

A novel therapeutic approach targeting rheumatoid arthritis by combined administration of morin, a dietary flavanol and non-steroidal anti-inflammatory drug indomethacin with reference to pro-inflammatory cytokines, inflammatory enzymes, RANKL and transcription factors

(2015) Farhath Sultana et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice

(2015) Susana Sánchez-Fidalgo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

(2015) S. Silva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model

(2015) Hiromi Matsuda et al.   LIFE SCIENCES

Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis

(2015) María Angeles Rosillo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

(2015) Yan He et al.   MOLECULES

DNA damage in non-communicable diseases: A clinical and epidemiological perspective

(2015) Mirta Milic et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes

(2015) Maria Carmen Crespo et al.   PHARMACOLOGICAL RESEARCH

The hydroxytyrosol-dependent increase of TNF-α in LPS-activated human monocytes is mediated by PGE2 and adenylate cyclase activation

(2015) R. Fuccelli et al.   TOXICOLOGY IN VITRO

New insights into the use of currently available non-steroidal anti-inflammatory drugs

(2015) Brune et al.   Journal of Pain Research

Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas

(2015) Laura Masuelli et al.   Oncotarget

Epigallocatechin-3-Gallate Potentiates the Effect of Curcumin in Inducing Growth Inhibition and Apoptosis of Resistant Breast Cancer Cells

(2014) Shengpeng Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Polyphenols in Disease: from Diet to Supplements

(2014) Ramon Rodrigo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Preventive Activity of Olive Oil Phenolic Compounds on Alkene Epoxides Induced Oxidative DNA Damage on Human Peripheral Blood Mononuclear Cells

(2014) Raffaela Fuccelli et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Vascular effects of the Mediterranean diet—Part II: Role of omega-3 fatty acids and olive oil polyphenols

(2014) Egeria Scoditti et al.   VASCULAR PHARMACOLOGY

Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats

(2014) María Tabernero et al.   Food & Function

Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition

(2013) Egeria Scoditti et al.   ATHEROSCLEROSIS

Functional foods and nutraceuticals as therapeutic tools for the treatment of diet-related diseases

(2013) Thea Magrone et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Toxicological evaluation of pure hydroxytyrosol

(2013) David Auñon-Calles et al.   FOOD AND CHEMICAL TOXICOLOGY

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

(2013) Henry J. Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice

(2013) Ke Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes

(2013) Patrizia Rosignoli et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice

(2013) Susana Sánchez-Fidalgo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Diet Rich in Olive Oil Phenolics Reduces Oxidative Stress in the Heart of SAMP8 Mice by Induction of Nrf2-Dependent Gene Expression

(2012) Banu Bayram et al.   REJUVENATION RESEARCH

Lack of effect of oral administration of resveratrol in LPS-induced systemic inflammation

(2011) M. Larrosa et al.   EUROPEAN JOURNAL OF NUTRITION

Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model

(2011) Susana Sánchez-Fidalgo et al.   EUROPEAN JOURNAL OF NUTRITION

Hydroxytyrosol Is the Major Anti-Inflammatory Compound in Aqueous Olive Extracts and Impairs Cytokine and Chemokine Production in Macrophages

(2011) Nathalie Richard et al.   PLANTA MEDICA

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

(2010) T. H. Page et al.   JOURNAL OF IMMUNOLOGY

Dna damage in human mononuclear cells induced by bacterial endotoxin

(2009) I. L. Glukhov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers

(2009) Daniela Giustarini et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells

(2009) Xiaomei Zhang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with α-linolenic acid on postprandial endothelial function in healthy men

(2008) F. Fuentes et al.   BRITISH JOURNAL OF NUTRITION

Anti-inflammatory activity of Acanthus ilicifolius

(2008) K.T. Mani Senthil Kumar et al.   JOURNAL OF ETHNOPHARMACOLOGY