Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
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Title
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
Authors
Keywords
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Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 24, Issue 12, Pages 1146-1154
Publisher
Springer Nature
Online
2017-11-07
DOI
10.1038/nsmb.3502
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Note: Only part of the references are listed.- Structure of a eukaryotic cyclic-nucleotide-gated channel
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- (2016) Mariana Grieben et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
- (2016) Abigail G Garrity et al. eLife
- Lysosomal Physiology
- (2015) Haoxing Xu et al. Annual Review of Physiology
- A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion
- (2015) Yuxuan Miao et al. CELL
- Organellar channels and transporters
- (2015) Haoxing Xu et al. CELL CALCIUM
- The role of TRPMLs in endolysosomal trafficking and function
- (2015) Kartik Venkatachalam et al. CELL CALCIUM
- Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels
- (2015) Sandip Patel et al. CELL CALCIUM
- Gene therapy for lysosomal storage disorders: a good start
- (2015) Alessandra Biffi HUMAN MOLECULAR GENETICS
- Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
- (2015) Wuyang Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging
- (2015) Tanmay A.M. Bharat et al. STRUCTURE
- Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1
- (2014) Xinghua Feng et al. CELL CALCIUM
- The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy
- (2014) Xiping Cheng et al. NATURE MEDICINE
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- (2014) A. Amunts et al. SCIENCE
- Endocytosis, Signaling, and Beyond
- (2014) P. P. Di Fiore et al. Cold Spring Harbor Perspectives in Biology
- A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis
- (2013) Mohammad Samie et al. DEVELOPMENTAL CELL
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- The lysosome: from waste bag to potential therapeutic target
- (2013) Hanna Appelqvist et al. Journal of Molecular Cell Biology
- Chloride in Vesicular Trafficking and Function
- (2012) Tobias Stauber et al. Annual Review of Physiology
- TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes
- (2012) Xiang Wang et al. CELL
- The intracellular Ca2+channels of membrane traffic
- (2012) Kirill K. Kiselyov et al. Channels
- Constitutive Activity of TRPML2 and TRPML3 ChannelsversusActivation by Low Extracellular Sodium and Small Molecules
- (2012) Christian Grimm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphoinositide isoforms determine compartment-specific ion channel activity
- (2012) X. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
- (2012) Dongbiao Shen et al. Nature Communications
- Mucolipidosis type IV: An update
- (2011) Kazuyo Wakabayashi et al. MOLECULAR GENETICS AND METABOLISM
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Small Molecule Activators of TRPML3
- (2010) Christian Grimm et al. CHEMISTRY & BIOLOGY
- Properties of the TRPML3 Channel Pore and Its Stable Expansion by the Varitint-Waddler-causing Mutation
- (2010) Hyun Jin Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRP channels of intracellular membranes
- (2010) Xian-Ping Dong et al. JOURNAL OF NEUROCHEMISTRY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Activating Mutations of the TRPML1 Channel Revealed by Proline-scanning Mutagenesis
- (2009) Xian-ping Dong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Motor Deficit in a Drosophila Model of Mucolipidosis Type IV due to Defective Clearance of Apoptotic Cells
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- A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype
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- Autophagic dysfunction in mucolipidosis type IV patients
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- Membrane traffic and turnover in TRP-ML1–deficient cells: a revised model for mucolipidosis type IV pathogenesis
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