Electron cryo-microscopy structure of the canonical TRPC4 ion channel

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dawning of a new era in TRP channel structural biology by cryo-electron microscopy

(2018) M. Gregor Madej et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

(2017) Marscha Hirschi et al.   NATURE

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

(2017) Qingfeng Chen et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

RosettaES: a sampling strategy enabling automated interpretation of difficult cryo-EM maps

(2017) Brandon Frenz et al.   NATURE METHODS

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE

(2017) Toshio Moriya et al.   Jove-Journal of Visualized Experiments

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

(2016) Peter S. Shen et al.   CELL

Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+Potentiation, and Ca2+Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel

(2016) Xingjuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane insertion of a Tc toxin in near-atomic detail

(2016) Christos Gatsogiannis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating

(2016) Dorothy M. Kim et al.   Cold Spring Harbor Perspectives in Biology

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane insertion of a Tc toxin in near-atomic detail

(2016) Christos Gatsogiannis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

(−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

(2015) Yasemin Akbulut et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

De novo protein structure determination from near-atomic-resolution cryo-EM maps

(2015) Ray Yu-Ruei Wang et al.   NATURE METHODS

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Moving gating charges through the gating pore in a Kv channel voltage sensor

(2014) J. J. Lacroix et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Conserved Gating Elements in TRPC4 and TRPC5 Channels

(2013) Andreas Beck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Scalable web services for the PSIPRED Protein Analysis Workbench

(2013) Daniel W. A. Buchan et al.   NUCLEIC ACIDS RESEARCH

Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome

(2012) Zhimiao Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Selective GαiSubunits as Novel Direct Activators of Transient Receptor Potential Canonical (TRPC)4 and TRPC5 Channels

(2012) Jae-Pyo Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations

(2012) R. Anandakrishnan et al.   NUCLEIC ACIDS RESEARCH

Iterative Stable Alignment and Clustering of 2D Transmission Electron Microscope Images

(2012) Zhengfan Yang et al.   STRUCTURE

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Phospholipid-binding Protein SESTD1 Is a Novel Regulator of the Transient Receptor Potential Channels TRPC4 and TRPC5

(2010) Susanne Miehe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1-dependent and STIM1-independent Function of Transient Receptor Potential Canonical (TRPC) Channels Tunes Their Store-operated Mode

(2010) Kyu Pil Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC channels are necessary mediators of pathologic cardiac hypertrophy

(2010) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface

(2008) Meredith A. Hannan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction

(2008) Weizhong Zeng et al.   MOLECULAR CELL

Sensing voltage across lipid membranes

(2008) Kenton J. Swartz   NATURE

The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels

(2007) Rainer Schindl et al.   CELL CALCIUM