Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK

(2017) Shanshan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reactive nitrogen species as therapeutic targets for autophagy: implication for ischemic stroke

(2017) Jinghan Feng et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-κB signaling pathway

(2017) Mohammad Raish   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Disrupted Ionic Homeostasis in Ischemic Stroke and New Therapeutic Targets

(2017) Hui-Jie Hu et al.   Journal of Stroke & Cerebrovascular Diseases

Effect of baicalin on oxygen–glucose deprivation-induced endothelial cell damage

(2017) Si Luo et al.   NEUROREPORT

Protective effect of chlorogenic acid on the focal cerebral ischemia reperfusion rat models

(2017) Mingsan Miao et al.   SAUDI PHARMACEUTICAL JOURNAL

Upregulation of caveolin-1 by mulberry leaf extract and its major components, chlorogenic acid derivatives, attenuates alcoholic steatohepatitis via inhibition of oxidative stress

(2017) Yi-Ju Lee et al.   Food & Function

The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury

(2017) Chao Guo et al.   Scientific Reports

Disrupted Ionic Homeostasis in Ischemic Stroke and New Therapeutic Targets

(2017) Hui-Jie Hu et al.   Journal of Stroke & Cerebrovascular Diseases

Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke

(2017) Atsushi Mizuma et al.   Frontiers in Neurology

Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus

(2016) Peng Wang et al.   BRAIN RESEARCH

One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke

(2016) Han-Sen Chen et al.   Current Neuropharmacology

Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death

(2016) Lei Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polysaccharide with antioxidant, α-amylase inhibitory and ACE inhibitory activities from Momordica charantia

(2016) Hwee-Feng Tan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Caveolin-1 Is Critical for Lymphocyte Trafficking into Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2016) Hao Wu et al.   JOURNAL OF NEUROSCIENCE

Antidepressant Potential of Chlorogenic Acid-Enriched Extract from Eucommia ulmoides Oliver Bark with Neuron Protection and Promotion of Serotonin Release through Enhancing Synapsin I Expression

(2016) Jianming Wu et al.   MOLECULES

Focusing on caveolin-1 in CNS autoimmune disease: multiple sclerosis

(2016) Jiangang Shen et al.   Neural Regeneration Research

Regulation of Caveolin-1 Expression Determines Early Brain Edema After Experimental Focal Cerebral Ischemia

(2016) Kang-Ho Choi et al.   STROKE

A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues

(2016) Tao Peng et al.   Chemical Science

Pros and Cons of Current Approaches for Detecting Peroxynitrite and Their Applications

(2016) Xingmiao Chen et al.   Biomedical Journal

Matrix metalloproteinases as therapeutic targets for stroke

(2015) Yi Yang et al.   BRAIN RESEARCH

Peroxynitrite Decomposition Catalyst Reduces Delayed Thrombolysis-induced Hemorrhagic Transformation in Ischemia-reperfused Rat Brains

(2015) Han-Sen Chen et al.   CNS Neuroscience & Therapeutics

Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB

(2015) Gui-Hua Quan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum Uric Acid Is Neuroprotective in Chinese Patients with Acute Ischemic Stroke Treated with Intravenous Recombinant Tissue Plasminogen Activator

(2015) Xuan Liu et al.   Journal of Stroke & Cerebrovascular Diseases

Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicity

(2015) Yoshinori Mikami et al.   LIFE SCIENCES

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

(2015) XIAOFENG LEI et al.   Molecular Medicine Reports

Calycosin-7-O-β-d-glucoside attenuates ischemia-reperfusion injury in vivo via activation of the PI3K/Akt pathway

(2015) MIN REN et al.   Molecular Medicine Reports

Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke

(2015) Zhongchao Wang et al.   MOLECULAR NEUROBIOLOGY

Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model

(2015) Kyungjin Lee et al.   MOLECULES

Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway

(2015) Juanjuan Gong et al.   NEUROPHARMACOLOGY

Serum Uric Acid Is Neuroprotective in Chinese Patients with Acute Ischemic Stroke Treated with Intravenous Recombinant Tissue Plasminogen Activator

(2015) Xuan Liu et al.   Journal of Stroke & Cerebrovascular Diseases

Treatment with lutein provides neuroprotection in mice subjected to transient cerebral ischemia

(2014) Ya-Xuan Sun et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Calycosin-7-O-β-d-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood–brain barrier integrity in experimental cerebral ischemia–reperfusion injury

(2014) Shuping Fu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Herbal Medicines for Ischemic Stroke: Combating Inflammation as Therapeutic Targets

(2014) Yong Gu et al.   Journal of Neuroimmune Pharmacology

Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats

(2014) Yong Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Drug Therapy in Stroke: From Preclinical to Clinical Studies

(2014) Harjeet Kaur et al.   PHARMACOLOGY

Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke

(2014) Dhirendra Pratap Singh et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Baicalin attenuates focal cerebral ischemic reperfusion injury by inhibition of protease-activated receptor-1 and apoptosis

(2013) Qing-bo Zhou et al.   Chinese Journal of Integrative Medicine

Complications Associated with Recombinant Tissue Plasminogen Activator Therapy for Acute Ischaemic Stroke

(2013) Joyce S. Balami et al.   CNS & Neurological Disorders-Drug Targets

Baicalin Regulates Neuronal Fate Decision in Neural Stem/Progenitor Cells and Stimulates Hippocampal Neurogenesis in Adult Rats

(2013) Peng-Wei Zhuang et al.   CNS Neuroscience & Therapeutics

Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients

(2013) J. Cassuto et al.   DIABETES

Effects of Uric Acid Levels on Outcome in Severe Ischemic Stroke Patients Treated with Intravenous Recombinant Tissue Plasminogen Activator

(2013) Sang-Hwa Lee et al.   EUROPEAN NEUROLOGY

Baicalin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage

(2013) Qing-Bo Zhou et al.   INFLAMMATION

Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans

(2013) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury

(2013) Mingjing Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Lycopene Inhibits Ischemia/Reperfusion-Induced Neuronal Apoptosis in Gerbil Hippocampal Tissue

(2013) Kimikazu Fujita et al.   NEUROCHEMICAL RESEARCH

Nitro-Oxidative Stress after Neuronal Ischemia Induces Protein Nitrotyrosination and Cell Death

(2013) Marta Tajes et al.   Oxidative Medicine and Cellular Longevity

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury

(2012) Xing-miao Chen et al.   ACTA PHARMACOLOGICA SINICA

Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia

(2012) Kyungjin Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats

(2012) Chao Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Plasma 3-nitrotyrosine estimates the reperfusion-induced cerebrovascular stress, whereas matrix metalloproteinases mainly reflect plasma activity: a study in patients treated with thrombolysis or endovascular recanalization

(2012) Demet Funda Bas et al.   JOURNAL OF NEUROCHEMISTRY

The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke

(2012) Mushfiquddin Khan et al.   JOURNAL OF NEUROCHEMISTRY

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Serum lycopene decreases the risk of stroke in men: A population-based follow-up study

(2012) J. Karppi et al.   NEUROLOGY

Caveolae, caveolins, cavins, and endothelial cell function: new insights

(2012) Grzegorz Sowa   Frontiers in Physiology

Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke

(2011) Taizen Nakase et al.   BMC Neurology

Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression

(2011) Yue Li et al.   BRAIN RESEARCH

Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways

(2011) Yonggang Cao et al.   BRAIN RESEARCH BULLETIN

Positron emission tomography molecular imaging for drug development

(2011) Paul M. Matthews et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain

(2011) Jean-François Jasmin et al.   CELL CYCLE

New Isoflavonoid Glycosides and Related Constituents from Astragali Radix (Astragalus membranaceus) and Their Inhibitory Activity on Nitric Oxide Production

(2011) Li-Jie Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Caveolin-1–eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability

(2011) M. Rizwan Siddiqui et al.   JOURNAL OF CELL BIOLOGY

Baicalin reduces the permeability of the blood–brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells

(2011) Haiyan Zhu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury

(2011) Yong Gu et al.   JOURNAL OF NEUROCHEMISTRY

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

(2011) Trent M Woodruff et al.   Molecular Neurodegeneration

Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke

(2011) Suk-Yee Li et al.   NEUROBIOLOGY OF DISEASE

Effect of Baicalin on Matrix Metalloproteinase-9 Expression and Blood–Brain Barrier Permeability Following Focal Cerebral Ischemia in Rats

(2011) Xian-kun Tu et al.   NEUROCHEMICAL RESEARCH

Caveolin-1 Plays a Crucial Role in Inhibiting Neuronal Differentiation of Neural Stem/Progenitor Cells via VEGF Signaling-Dependent Pathway

(2011) Yue Li et al.   PLoS One

Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor κB p65 activation

(2010) Xia Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation

(2010) J. H. Chidlow et al.   CARDIOVASCULAR RESEARCH

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen–glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo

(2010) Huiying Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Baicalin Inhibits TLR2/4 Signaling Pathway in Rat Brain Following Permanent Cerebral Ischemia

(2010) Xian-kun Tu et al.   INFLAMMATION

Neuroprotective effect of Momordica charantia in global cerebral ischemia and reperfusion induced neuronal damage in diabetic mice

(2010) Zafar Ahmad Malik et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Peroxynitrite decomposition catalyst prevents matrix metalloproteinase activation and neurovascular injury after prolonged cerebral ischemia in rats

(2010) Yalikun Suofu et al.   JOURNAL OF NEUROCHEMISTRY

Evaluation of 11C-GSK189254 as a Novel Radioligand for the H3 Receptor in Humans Using PET

(2010) S. Ashworth et al.   JOURNAL OF NUCLEAR MEDICINE

Matrix Metalloproteinase-9 as a Marker for Acute Ischemic Stroke: A Systematic Review

(2010) Maria Ramos-Fernandez et al.   Journal of Stroke & Cerebrovascular Diseases

Protection of PC12 Cells against Superoxide-induced Damage by Isoflavonoids from Astragalus mongholicus

(2009) De-Hong YU et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Nitric Oxide Regulates Lung Carcinoma Cell Anoikis through Inhibition of Ubiquitin-Proteasomal Degradation of Caveolin-1

(2009) Pithi Chanvorachote et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

(2009) You-Yang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Baicalin administration is effective in positive regulation of twenty-four ischemia/reperfusion-related proteins identified by a proteomic study

(2009) Zhanjun Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Expression of endothelial phosphorylated caveolin-1 is increased in brain injury

(2009) S. Nag et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Nitration reaction of lutein with peroxynitrite

(2009) Makoto Tsuboi et al.   TETRAHEDRON LETTERS

Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione

(2008) Serena Viappiani et al.   BIOCHEMICAL PHARMACOLOGY

Deletion of Cavin/PTRF Causes Global Loss of Caveolae, Dyslipidemia, and Glucose Intolerance

(2008) Libin Liu et al.   Cell Metabolism

Simultaneous determination of calycosin-7-O-β-d-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of Danggui Buxue Tang extract for their pharmacokinetic studies by liquid chromatography–mass spectrometry

(2008) Xiao-Dong Wen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry

(2008) H HUANG et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release

(2008) Eloy Cuadrado et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interaction of caveolin-1, nitric oxide, and nitric oxide synthases in hypoxic human SK-N-MC neuroblastoma cells

(2008) Jiangang Shen et al.   JOURNAL OF NEUROCHEMISTRY

Systemic Inflammation Alters the Kinetics of Cerebrovascular Tight Junction Disruption after Experimental Stroke in Mice

(2008) B. W. McColl et al.   JOURNAL OF NEUROSCIENCE

Coupling between neuronal nitric oxide synthase and glutamate receptor 6–mediated c-Jun N-terminal kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death

(2008) H.-M. Yu et al.   NEUROSCIENCE

Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons

(2008) Han-Qing Chen et al.   NEUROSCIENCE RESEARCH

Allopurinol Use Yields Potentially Beneficial Effects on Inflammatory Indices in Those With Recent Ischemic Stroke

(2008) Scott W. Muir et al.   STROKE

MMP-9–Positive Neutrophil Infiltration Is Associated to Blood–Brain Barrier Breakdown and Basal Lamina Type IV Collagen Degradation During Hemorrhagic Transformation After Human Ischemic Stroke

(2008) Anna Rosell et al.   STROKE