BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism

The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6

(2014) C. Mayeur et al.   BLOOD

Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype

(2014) S. Zumerle et al.   BLOOD

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

(2014) Michael Dussiot et al.   NATURE MEDICINE

Iron Deficiency in Patients With Idiopathic Pulmonary Arterial Hypertension

(2013) Vanessa P.M. van Empel et al.   Heart Lung and Circulation

Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation

(2013) J. Bagarova et al.   MOLECULAR AND CELLULAR BIOLOGY

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Deletion of the Sequence Encoding the Tail Domain of the Bone Morphogenetic Protein type 2 Receptor Reveals a Bone Morphogenetic Protein 7-Specific Gain of Function

(2013) Patricio A. Leyton et al.   PLoS One

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

A pair of transmembrane receptors essential for the retention and pigmentation of hair

(2012) Rong Han et al.   GENESIS

Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs)

(2012) Qifang Wu et al.   PLoS One

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Iron sensing and signalling

(2011) Rayko Evstatiev et al.   GUT

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension

(2011) Christopher J. Rhodes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension

(2011) E. Soon et al.   THORAX

Iron deficiency is common in idiopathic pulmonary arterial hypertension

(2010) G. Ruiter et al.   EUROPEAN RESPIRATORY JOURNAL

Iron overload induces BMP6 expression in the liver but not in the duodenum

(2010) L. Kautz et al.   HAEMATOLOGICA

Bone morphogenetic protein receptors and signal transduction

(2009) K. Miyazono et al.   JOURNAL OF BIOCHEMISTRY

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

(2009) Paul D. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells

(2008) Karen Lavery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS