Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

(2016) A. Nai et al.   BLOOD

LC-MS/MS method for hepcidin-25 measurement in human and mouse serum: clinical and research implications in iron disorders

(2015) Thibaud Lefebvre et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

(2015) Chloé Latour et al.   HEPATOLOGY

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

(2014) P. Gutschow et al.   HAEMATOLOGICA

Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub

(2013) C. H. Bell et al.   SCIENCE

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

Neogenin Interacts with Matriptase-2 to Facilitate Hemojuvelin Cleavage

(2012) Caroline A. Enns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

(2011) W. Chen et al.   BLOOD

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Conditional disruption of mouse HFE2 gene: Maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin

(2011) Konstantinos Gkouvatsos et al.   HEPATOLOGY

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

(2010) K. E. Finberg et al.   BLOOD

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

(2010) D. H. Lee et al.   BLOOD

Matriptase-2- and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression

(2010) Julia E. Maxson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Hepatocyte Hemojuvelin in the Regulation of Bone Morphogenic Protein-6 and Hepcidin Expressionin Vivo

(2010) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression

(2009) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin

(2008) Robin Kuns-Hashimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neogenin Interacts with Hemojuvelin through Its Two Membrane-Proximal Fibronectin Type III Domains†

(2008) Fan Yang et al.   BIOCHEMISTRY

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

(2008) J. E. Maxson et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Neogenin-mediated Hemojuvelin Shedding Occurs after Hemojuvelin Traffics to the Plasma Membrane

(2008) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD

Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site

(2007) Lan Lin et al.   BLOOD CELLS MOLECULES AND DISEASES

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

(2007) Erika V. Valore et al.   BLOOD CELLS MOLECULES AND DISEASES