Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women?

(2015) M. Malvezzi et al.   ANNALS OF ONCOLOGY

Natural compounds and pharmaceuticals reprogram leukemia cell differentiation pathways

(2015) Franck Morceau et al.   BIOTECHNOLOGY ADVANCES

Effects of Natural Products on Mcl-1 Expression and Function

(2015) Florian Muller et al.   CURRENT MEDICINAL CHEMISTRY

Editorial (Thematic Issue: Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic Readers, Writers and Erasers as Therapeutic Targets)

(2015) Michael Schnekenburger et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug Discovery

(2015) Jin-Young Lee et al.   Marine Drugs

A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2012

(2015) Wamtinga Sawadogo et al.   MOLECULES

Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2

(2015) Michael Tsabar et al.   NUCLEIC ACIDS RESEARCH

Caffeine acts through neuronal adenosine A2Areceptors to prevent mood and memory dysfunction triggered by chronic stress

(2015) Manuella P. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abstract 4685: Caffeine and caffeic acid inhibit growth and modify estrogen receptor (ER)-α and insulin-like growth factor I receptor (IGF-IR) levels in human breast cancer

(2015) Ann H. Rosendahl et al.   CANCER RESEARCH

Stable Radical Content and Anti-Radical Activity of Roasted Arabica Coffee: From In-Tact Bean to Coffee Brew

(2015) Gordon J. Troup et al.   PLoS One

Coffee Inhibits Adipocyte Differentiation via Inactivation of PPARγ

(2014) Ryohei Aoyagi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Plant-derived epigenetic modulators for cancer treatment and prevention

(2014) Michael Schnekenburger et al.   BIOTECHNOLOGY ADVANCES

From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment

(2014) Claudia Cerella et al.   BIOTECHNOLOGY ADVANCES

Stability of phenolic compounds and antioxidant capacity of regular and decaffeinated coffees

(2014) Silvio José Valadão Vicente et al.   BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY

Coffea arabica instant coffee—Chemical view and immunomodulating properties

(2014) Peter Capek et al.   CARBOHYDRATE POLYMERS

Caffeine Inhibits Migration in Glioma Cells through the ROCK-FAK Pathway

(2014) Ying Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Beneficial mycorrhizal symbionts affecting the production of health-promoting phytochemicals

(2014) Cristiana Sbrana et al.   ELECTROPHORESIS

The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

(2014) Merve Bacanlı et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study

(2014) Leah M. Ferrucci et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Consumption of a dark roast coffee decreases the level of spontaneous DNA strand breaks: a randomized controlled trial

(2014) T. Bakuradze et al.   EUROPEAN JOURNAL OF NUTRITION

Coffee with cinnamon – Impact of phytochemicals interactions on antioxidant and anti-inflammatory in vitro activity

(2014) Agata Durak et al.   FOOD CHEMISTRY

Influence of molecular weight on in vitro immunostimulatory properties of instant coffee

(2014) Cláudia P. Passos et al.   FOOD CHEMISTRY

The kinetics of coffee aroma extraction

(2014) Frédéric Mestdagh et al.   FOOD RESEARCH INTERNATIONAL

Mechanistic elucidation of apoptosis and cell cycle arrest induced by 5-hydroxymethylfurfural, the important role of ROS-mediated signaling pathways

(2014) Ling Zhao et al.   FOOD RESEARCH INTERNATIONAL

Bioactive compounds content in roasted coffee from traditional and modern Coffea arabica cultivars grown under the same edapho-climatic conditions

(2014) Cíntia Sorane Good Kitzberger et al.   FOOD RESEARCH INTERNATIONAL

Modulation of inflammatory gene transcription after long-term coffee consumption

(2014) Swantje Winkler et al.   FOOD RESEARCH INTERNATIONAL

Green coffee hydroxycinnamic acids but not caffeine protect human HepG2 cells against oxidative stress

(2014) Gema Baeza et al.   FOOD RESEARCH INTERNATIONAL

Four-week coffee consumption affects energy intake, satiety regulation, body fat, and protects DNA integrity

(2014) Tamara Bakuradze et al.   FOOD RESEARCH INTERNATIONAL

Phytochemical and microbiological stability of spent espresso coffee grounds in capsules

(2014) Simona Belviso et al.   FOOD RESEARCH INTERNATIONAL

Neapolitan coffee brew chemical analysis in comparison to espresso, moka and American brews

(2014) Nicola Caporaso et al.   FOOD RESEARCH INTERNATIONAL

Plumbagin Modulates Leukemia Cell Redox Status

(2014) François Gaascht et al.   MOLECULES

Tetrandrine and Caffeine Modulated Cell Cycle and Increased Glioma Cell Death via Caspase-Dependent and Caspase-Independent Apoptosis Pathways

(2014) Jin-Cherng Chen et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Anti-Proliferative Properties of Kahweol in Oral Squamous Cancer Through the Regulation Specificity Protein 1

(2014) Jung-Il Chae et al.   PHYTOTHERAPY RESEARCH

Modulation of Fibroblast Growth Factor 19 Expression by Bile Acids, Meal Replacement and Energy Drinks, Milk, and Coffee

(2014) Amanda M. Styer et al.   PLoS One

Impact of caffeine and coffee on our health

(2014) Elvira Gonzalez de Mejia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Caffeine Intake May Modulate Inflammation Markers in Trained Rats

(2014) Rômulo Barcelos et al.   Nutrients

Anti-Cell Proliferative Efficacy of Ferulic Acid Against 7, 12-dimethylbenz(a) Anthracene Induced Hamster Buccal Pouch Carcinogenesis

(2013) M. Manoj Prabhakar et al.   Asian Pacific Journal of Cancer Prevention

Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions

(2013) Marie-Hélène Teiten et al.   BIOCHEMICAL PHARMACOLOGY

Catabolism of coffee chlorogenic acids by human colonic microbiota

(2013) Iziar A. Ludwig et al.   BIOFACTORS

Chlorogenic Acid Inhibits Osteoclast Differentiation and Bone Resorption by Down-Regulation of Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Nuclear Factor of Activated T Cells c1 Expression

(2013) Sung Chul Kwak et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Coffee component hydroxyl hydroquinone (HHQ) as a putative ligand for PPAR gamma and implications in breast cancer

(2013) Babita Shashni et al.   BMC GENOMICS

Melanoidins isolated from heated potato fiber (Potex) affect human colon cancer cells growth via modulation of cell cycle and proliferation regulatory proteins

(2013) Ewa Langner et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant and genoprotective effects of spent coffee extracts in human cells

(2013) Jimena Bravo et al.   FOOD AND CHEMICAL TOXICOLOGY

The effect of processing on chlorogenic acid content of commercially available coffee

(2013) Charlotte E. Mills et al.   FOOD CHEMISTRY

Volatile composition and antioxidant capacity of Arabica coffee

(2013) Mun Wai Cheong et al.   FOOD RESEARCH INTERNATIONAL

Scavenging capacity of coffee brews against oxygen and nitrogen reactive species and the correlation with bioactive compounds by multivariate analysis

(2013) Naira Poerner Rodrigues et al.   FOOD RESEARCH INTERNATIONAL

Study on the Postprandial Glucose Responses to a Chlorogenic Acid-Rich Extract of Decaffeinated Green Coffee Beans in Rats and Healthy Human Subjects

(2013) Kazuya IWAI et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells

(2013) Su Jung Hwang et al.   INFLAMMATION RESEARCH

Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes

(2013) Guan-Yu Lu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cancer Prevention for the Next Generation

(2013) Mary C. White et al.   JOURNAL OF ADOLESCENT HEALTH

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

(2013) Michelle Cristiane Búfalo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Identification and quantification of bioactive compounds in coffee brews by HPLC–DAD–MSn

(2013) Naira Poerner Rodrigues et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model

(2013) Sung Gon Shim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Embellicines A and B: Absolute Configuration and NF-κB Transcriptional Inhibitory Activity

(2013) Weaam Ebrahim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of sugar addition (torrefacto) during roasting process on antioxidant capacity and phenolics of coffee

(2013) Iziar A. Ludwig et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

The impact of coffee on health

(2013) A. Cano-Marquina et al.   MATURITAS

Protective effects of coffee against induction of DNA damage and pre-neoplastic foci by aflatoxin B1

(2013) Franziska Ferk et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Targeting cell cycle regulation in cancer therapy

(2013) Santiago Diaz-Moralli et al.   PHARMACOLOGY & THERAPEUTICS

Caffeine in Floral Nectar Enhances a Pollinator's Memory of Reward

(2013) G. A. Wright et al.   SCIENCE

Anti-inflammatory effect of aqueous extracts of roasted and green Coffea arabica L.

(2013) Maria Eliza de Castro Moreira et al.   Journal of Functional Foods

Alternative lengthening of telomeres: remodeling the telomere architecture

(2013) Dimitri Conomos et al.   Frontiers in Oncology

Coffee, Tea, and Fatal Oral/Pharyngeal Cancer in a Large Prospective US Cohort

(2012) J. S. Hildebrand et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site

(2012) Paola Ojeda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells

(2012) Shuaiyu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Traditional West African pharmacopeia, plants and derived compounds for cancer therapy

(2012) Wamtinga Richard Sawadogo et al.   BIOCHEMICAL PHARMACOLOGY

Ferulic Acid Inhibits Gamma Radiation-Induced DNA Strand Breaks and Enhances the Survival of Mice

(2012) Dharmendra Kumar Maurya et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Caffeine treatment disturbs the angiogenesis of zebrafish embryos

(2012) Chien-Hung Yeh et al.   DRUG AND CHEMICAL TOXICOLOGY

Method Validation for Cafestol and Kahweol Quantification in Coffee Brews by HPLC-DAD

(2012) José A. Silva et al.   Food Analytical Methods

Determination of the Elemental Composition of Coffee Using Instrumental Methods

(2012) Pawel Pohl et al.   Food Analytical Methods

Bioactive composition and antioxidant potential of different commonly consumed coffee brews affected by their preparation technique and milk addition

(2012) Tena Niseteo et al.   FOOD CHEMISTRY

The coffee diterpene kahweol inhibits metastasis by modulating expressions of MMPs and VEGF via STAT3 inactivation

(2012) Hyung Gyun Kim et al.   FOOD CHEMISTRY

Extraction of coffee antioxidants: Impact of brewing time and method

(2012) Iziar A. Ludwig et al.   FOOD RESEARCH INTERNATIONAL

The Type and Concentration of Milk Increase the in Vitro Bioaccessibility of Coffee Chlorogenic Acids

(2012) Davide Tagliazucchi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Coffee Combining Green Coffee Bean Constituents with Typical Roasting Products on the Nrf2/ARE Pathway in Vitro and in Vivo

(2012) Nadine Volz et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Influence of the Degree of Roasting on the Antioxidant Capacity and Genoprotective Effect of Instant Coffee: Contribution of the Melanoidin Fraction

(2012) Raquel Del Pino-García et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Influence of Coffee Roasting on the Incorporation of Phenolic Compounds into Melanoidins and Their Relationship with Antioxidant Activity of the Brew

(2012) Daniel Perrone et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Coffee Constituent Chlorogenic Acid Induces Cellular DNA Damage and Formation of Topoisomerase I– and II–DNA Complexes in Cells

(2012) Estefanía Burgos-Morón et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Roasting Process of Coffee Beans as Studied by Nuclear Magnetic Resonance: Time Course of Changes in Composition

(2012) Feifei Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

13C NMR-Based Metabolomics for the Classification of Green Coffee Beans According to Variety and Origin

(2012) Feifei Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antiangiogenic Effects ofP-Coumaric Acid in Human Endothelial Cells

(2012) Chang-Seok Kong et al.   PHYTOTHERAPY RESEARCH

Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway

(2012) Haitao Shi et al.   TOXICOLOGY

Coffee melanoidins: structures, mechanisms of formation and potential health impacts

(2012) Ana S. P. Moreira et al.   Food & Function

Flaking process increases the NF-κB inhibition activity and melanoidin extractability of coffee

(2012) Yi-Fang Chu et al.   Food Science & Nutrition

Targeting tumor cell motility to prevent metastasis

(2011) Trenis D. Palmer et al.   ADVANCED DRUG DELIVERY REVIEWS

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer

(2011) Marc Schumacher et al.   BIOTECHNOLOGY ADVANCES

Coffee consumption and risk of cancers: a meta-analysis of cohort studies

(2011) Xiaofeng Yu et al.   BMC CANCER

Caffeine Alters Cytokine Secretion by PBMC Induced by Colon Cancer Cells

(2011) Hanna Bessler et al.   CANCER INVESTIGATION

Structure of arabinogalactan oligosaccharides derived from arabinogalactan-protein of Coffea arabica instant coffee powder

(2011) Mária Matulová et al.   CARBOHYDRATE RESEARCH

Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK

(2011) Nam Joo Kang et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation

(2011) Min Jung Choi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Comparative study of polyphenols and caffeine in different coffee varieties affected by the degree of roasting

(2011) Ivana Hečimović et al.   FOOD CHEMISTRY

Effect of roasting conditions and grinding on free radical contents of coffee beans stored in air

(2011) C. Yeretzian et al.   FOOD CHEMISTRY

Antitussive and immunomodulating activities of instant coffee arabinogalactan-protein

(2011) G. Nosáľová et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effects of roasting degree on radical scavenging activity, phenolics and volatile compounds of Arabica coffee beans (Coffea arabica L. cv. Catimor)

(2011) Chanyarin Somporn et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Antiproliferative Activity of Melanoidins Isolated from Heated Potato Fiber (Potex) in Glioma Cell Culture Model

(2011) Ewa Langner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Antioxidant and Chlorogenic Acid Profiles of Whole Coffee Fruits Are Influenced by the Extraction Procedures

(2011) W. Mullen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

High Molecular Weight Coffee Melanoidins Are Inhibitors for Matrix Metalloproteases

(2011) Leticia Missagia De Marco et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Identification of novel circulating coffee metabolites in human plasma by liquid chromatography–mass spectrometry

(2011) Karine Redeuil et al.   JOURNAL OF CHROMATOGRAPHY A

Supercritical CO2 Decaffeination of Unroasted Coffee Beans Produces Melanoidins with Distinct NF-κB Inhibitory Activity

(2011) Yumin Chen et al.   JOURNAL OF FOOD SCIENCE

Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

(2011) Ute Boettler et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Antiproliferative Effect of Dietary Fiber Phenolic Compounds Ferulic Acid and p-Coumaric Acid on the Cell Cycle of Caco-2 Cells

(2011) Birgit Janicke et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene

(2011) Casimiro Cárdenas et al.   PLoS One

Caffeinated Coffee, Decaffeinated Coffee and Endometrial Cancer Risk: A Prospective Cohort Study among US Postmenopausal Women

(2011) Ayush Giri et al.   Nutrients

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice

(2010) Ae-Sim Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid

(2010) Yuki Sato et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Contribution of Chlorogenic Acids to the Inhibition of Human Hepatic Glucose-6-phosphatase Activity in Vitro by Svetol, a Standardized Decaffeinated Green Coffee Extract

(2010) Caroline Henry-Vitrac et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway

(2010) Wen-Hsin Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bioavailability of dietary flavonoids and phenolic compounds

(2010) Alan Crozier et al.   MOLECULAR ASPECTS OF MEDICINE

Roles for Growth Factors in Cancer Progression

(2010) Esther Witsch et al.   PHYSIOLOGY

Chlorogenic acids and other relevant compounds in Brazilian coffees processed by semi-dry and wet post-harvesting methods

(2009) Giselle S. Duarte et al.   FOOD CHEMISTRY

Chemopreventive potential of curcumin in prostate cancer

(2009) Marie-Hélène Teiten et al.   Genes and Nutrition

Increased caffeine consumption is associated with reduced hepatic fibrosis

(2009) Apurva A. Modi et al.   HEPATOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation

(2009) John P Alao et al.   Radiation Oncology

Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: population based case-control study

(2009) F. Islami et al.   BMJ-British Medical Journal

Caffeic acid decomposition products: Antioxidants or pro-oxidants?

(2008) Susana Andueza et al.   FOOD RESEARCH INTERNATIONAL