Dendritic Cell-Based Vaccination in Cancer: Therapeutic Implications Emerging from Murine Models

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow

(2015) Jaeyop Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Ag-Presenting CpG-Activated pDCs Prime Th17 Cells That Induce Tumor Regression

(2014) L. Guery et al.   CANCER RESEARCH

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

(2014) M. Dalod et al.   EMBO JOURNAL

Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance

(2014) V. Flacher et al.   EMBO Molecular Medicine

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens

(2014) Pooja Arora et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Intrarectal Vaccination with Recombinant Vaccinia Virus Expressing Carcinoembronic Antigen Induces Mucosal and Systemic Immunity and Prevents Progression of Colorectal Cancer

(2014) S. Kim-Schulze et al.   JOURNAL OF IMMUNOLOGY

Tumor Immunotherapy by Epicutaneous Immunization Requires Langerhans Cells

(2014) P. Stoitzner et al.   JOURNAL OF IMMUNOLOGY

Invariant NKT Cells Promote CD8+ Cytotoxic T Cell Responses by Inducing CD70 Expression on Dendritic Cells

(2014) V. Y. Taraban et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Langerin/CD207 Receptor on Dendritic Cells Mediates Efficient Antigen Presentation on MHC I and II Products In Vivo

(2014) J. Idoyaga et al.   JOURNAL OF IMMUNOLOGY

Human XCR1+Dendritic Cells Derived In Vitro from CD34+Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells

(2014) Sreekumar Balan et al.   JOURNAL OF IMMUNOLOGY

Targeted Delivery of α-Galactosylceramide to CD8α+Dendritic Cells Optimizes Type I NKT Cell–Based Antitumor Responses

(2014) Elodie Macho-Fernandez et al.   JOURNAL OF IMMUNOLOGY

Antigen Targeting to CD11b+Dendritic Cells in Association with TLR4/TRIF Signaling Promotes Strong CD8+T Cell Responses

(2014) Gilles Dadaglio et al.   JOURNAL OF IMMUNOLOGY

Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1

(2014) Evelyn Hartung et al.   JOURNAL OF IMMUNOLOGY

A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells

(2014) Siyuan Xia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Multiple murine BRafV600Emelanoma cell lines with sensitivity to PLX4032

(2014) Molly H. Jenkins et al.   Pigment Cell & Melanoma Research

Dendritic Cell-Mediated, DNA-Based Vaccination against Hepatitis C Induces the Multi-Epitope-Specific Response of Humanized, HLA Transgenic Mice

(2014) Sasmita Mishra et al.   PLoS One

Induction of Antigen-Specific Immunity with a Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205

(2014) M. V. Dhodapkar et al.   Science Translational Medicine

CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice

(2014) María Sol Ruiz et al.   VACCINE

TLR7 Ligand Augments GM-CSF-Initiated Antitumor Immunity through Activation of Plasmacytoid Dendritic Cells

(2014) M. Narusawa et al.   Cancer Immunology Research

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Superior anti-tumor protection and therapeutic efficacy of vaccination with dendritic cell/tumor cell fusion hybrids for murine Lewis lung carcinoma

(2013) Xiaodan Chen et al.   AUTOIMMUNITY

CD141+ dendritic cells produce prominent amounts of IFN-  after dsRNA recognition and can be targeted via DEC-205 in humanized mice

(2013) S. Meixlsperger et al.   BLOOD

Tumor Promotion by Intratumoral Plasmacytoid Dendritic Cells Is Reversed by TLR7 Ligand Treatment

(2013) I. Le Mercier et al.   CANCER RESEARCH

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

Heat-shock proteins as dendritic cell-targeting vaccines - getting warmer

(2013) Shaun McNulty et al.   IMMUNOLOGY

Intradermal immunization with combined baculovirus and tumor cell lysate induces effective antitumor immunity in mice

(2013) MAMORU KAWAHARA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Melanoma immunotherapy using mature DCs expressing the constitutive proteasome

(2013) Jens Dannull et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-12p70–producing patient DC vaccine elicits Tc1-polarized immunity

(2013) Beatriz M. Carreno et al.   JOURNAL OF CLINICAL INVESTIGATION

Local secretion of IL-12 augments the therapeutic impact of dendritic cell–tumor cell fusion vaccination

(2013) Chunrui Tan et al.   JOURNAL OF SURGICAL RESEARCH

Fusion of Hsp70 to Mage-a1 enhances the potency of vaccine-specific immune responses

(2013) Juhong Jiang et al.   Journal of Translational Medicine

Origin of the vasculature supporting growth of primary patient tumor xenografts

(2013) Bonnie L Hylander et al.   Journal of Translational Medicine

Patient-derived xenografts, the cancer stem cell paradigm and cancer pathobiology in the 21st century

(2013) Samuel A Williams et al.   LABORATORY INVESTIGATION

Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

(2013) F. Sandoval et al.   Science Translational Medicine

Inflammatory dendritic cells in mice and humans

(2013) Elodie Segura et al.   TRENDS IN IMMUNOLOGY

Dendritic Cells in Cancer Immunotherapy Clinical Trials: Are We Making Progress?

(2013) Lisa H. Butterfield   Frontiers in Immunology

Strategies to improve the immunogenicity of anticancer vaccines based on dendritic cell/malignant cell fusions

(2013) shigeo koido et al.   OncoImmunology

Identification of human inflammatory dendritic cells

(2013) Elodie Segura et al.   OncoImmunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues

(2012) L. F. Poulin et al.   BLOOD

ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T Cells

(2012) J. Faget et al.   CANCER RESEARCH

Impaired IFN-  Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

(2012) V. Sisirak et al.   CANCER RESEARCH

Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity

(2012) N. Ning et al.   CANCER RESEARCH

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

Plasmacytoid Dendritic Cells Promote Immunosuppression in Ovarian Cancer via ICOS Costimulation of Foxp3+ T-Regulatory Cells

(2012) C. Conrad et al.   CANCER RESEARCH

Engineering humanized mice for improved hematopoietic reconstitution

(2012) Adam C Drake et al.   Cellular & Molecular Immunology

Dendritic Cell-Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells

(2012) Y. Dang et al.   CLINICAL CANCER RESEARCH

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells

(2012) Barbara Drobits et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of the Processing of Seven Human Tumor Antigens by Intermediate Proteasomes

(2012) B. Guillaume et al.   JOURNAL OF IMMUNOLOGY

NOD/scid IL-2Rgnull mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo

(2012) Stefani Spranger et al.   Journal of Translational Medicine

Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System

(2012) Ilse Van Brussel et al.   MEDIATORS OF INFLAMMATION

Intestinal CD103− dendritic cells migrate in lymph and prime effector T cells

(2012) V Cerovic et al.   Mucosal Immunology

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Synergistic antitumor effect of JAWSII dendritic cells and interleukin 12 in a melanoma mouse model

(2012) ŁUKASZ ZAPAŁA et al.   ONCOLOGY REPORTS

Cross-dressed CD8 +/CD103+ dendritic cells prime CD8+ T cells following vaccination

(2012) L. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The three main stumbling blocks for anticancer T cells

(2012) Lukas Baitsch et al.   TRENDS IN IMMUNOLOGY

Anti-melanoma vaccinal capacity of CD11c-positive and -negative cell populations present in GM-CSF cultures derived from murine bone marrow precursors

(2012) Sabrina Campisano et al.   VACCINE

Targeting cancer stem cells via dendritic-cell vaccination

(2012) Seagal Teitz-Tennenbaum et al.   OncoImmunology

Trial watch

(2012) Lorenzo Galluzzi et al.   OncoImmunology

Mouse Models of Cancer

(2011) Dong-Joo Cheon et al.   Annual Review of Pathology-Mechanisms of Disease

Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers

(2011) L. H. Butterfield et al.   CLINICAL CANCER RESEARCH

Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine

(2011) Kanako L. Lewis et al.   IMMUNITY

Parenteral is more efficient than mucosal immunization to induce regression of human papillomavirus-associated genital tumors

(2011) Loane Decrausaz et al.   INTERNATIONAL JOURNAL OF CANCER

FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer

(2011) Stephanie K. Watkins et al.   JOURNAL OF CLINICAL INVESTIGATION

CD103+pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

(2011) A. Nicole Desch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic Vaccination With an Autologous mRNA Electroporated Dendritic Cell Vaccine in Patients With Advanced Melanoma

(2011) Sofie Wilgenhof et al.   JOURNAL OF IMMUNOTHERAPY

Exploiting the Role of Endogenous Lymphoid-Resident Dendritic Cells in the Priming of NKT Cells and CD8+ T Cells to Dendritic Cell-Based Vaccines

(2011) Troels R. Petersen et al.   PLoS One

Dendritic Cells Crosspresent Antigens from Live B16 Cells More Efficiently than from Apoptotic Cells and Protect from Melanoma in a Therapeutic Model

(2011) Diana Matheoud et al.   PLoS One

Boosting antibody responses by targeting antigens to dendritic cells

(2011) Irina Caminschi et al.   TRENDS IN IMMUNOLOGY

Cross-presentation by dendritic cells from live cells induces protective immune responses in vivo

(2010) D. Matheoud et al.   BLOOD

The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice

(2010) Fang Ma et al.   Cellular & Molecular Immunology

Superior Efficacy of Tumor Cell Vaccines Grown in Physiologic Oxygen

(2010) M. R. Olin et al.   CLINICAL CANCER RESEARCH

Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy

(2010) Robert M. Prins et al.   CLINICAL CANCER RESEARCH

Recent advances in processing and presentation of CD1 bound lipid antigens

(2010) Mariolina Salio et al.   CURRENT OPINION IN IMMUNOLOGY

The CD8+dendritic cell subset

(2010) Ken Shortman et al.   IMMUNOLOGICAL REVIEWS

Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation

(2010) Pilar M. Domínguez et al.   IMMUNOLOGICAL REVIEWS

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid Dendritic Cells Alter the Antitumor Activity of CpG-Oligodeoxynucleotides in a Mouse Model of Lung Carcinoma

(2010) R. Sorrentino et al.   JOURNAL OF IMMUNOLOGY

Langerin+ Dermal Dendritic Cells Are Critical for CD8+ T Cell Activation and IgH  -1 Class Switching in Response to Gene Gun Vaccines

(2010) A. Stoecklinger et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Dual Stimulation of MyD88‐Dependent Toll‐Like Receptors Induces Synergistically Enhanced Production of Inflammatory Cytokines in Murine Bone Marrow–Derived Dendritic Cells

(2010) Daniel Mitchell et al.   JOURNAL OF INFECTIOUS DISEASES

Reconstitution of huPBL-NSG Mice with Donor-Matched Dendritic Cells Enables Antigen-Specific T-cell Activation

(2010) Airi Harui et al.   Journal of Neuroimmune Pharmacology

CD8+ T Cell Priming by Dendritic Cell Vaccines Requires Antigen Transfer to Endogenous Antigen Presenting Cells

(2010) Alice W. Yewdall et al.   PLoS One

B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase

(2010) B. A. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue

(2010) Soledad Mac Keon et al.   VACCINE

Costimulatory ligand CD70 allows induction of CD8+ T-cell immunity by immature dendritic cells in a vaccination setting

(2009) A. M. Keller et al.   BLOOD

Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches

(2009) Terry J. Fry et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Enhancement of Th1 immune response by CD8α+ dendritic cells loaded with heat shock proteins enriched tumor extract in tumor-bearing mice

(2009) Abbas Azadmehr et al.   CELLULAR IMMUNOLOGY

Targeted Delivery of Tumor Antigens to Activated Dendritic Cells via CD11c Molecules Induces Potent Antitumor Immunity in Mice

(2009) H. Wei et al.   CLINICAL CANCER RESEARCH

Allogeneic GM-CSF-secreting tumor cell immunotherapies generate potent anti-tumor responses comparable to autologous tumor cell immunotherapies

(2009) Betty Li et al.   CLINICAL IMMUNOLOGY

The origin and development of nonlymphoid tissue CD103+DCs

(2009) Florent Ginhoux et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD207+CD103+dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

(2009) Sandrine Henri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

(2009) Olga Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PDCA Expression by B Lymphocytes Reveals Important Functional Attributes

(2009) D. S. Vinay et al.   JOURNAL OF IMMUNOLOGY

Langerin+CD8 + Dendritic Cells Are Critical for Cross-Priming and IL-12 Production in Response to Systemic Antigens

(2009) K. J. Farrand et al.   JOURNAL OF IMMUNOLOGY

Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

(2009) P. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Epidermal Langerhans Cells Rapidly Capture and Present Antigens from C-Type Lectin-Targeting Antibodies Deposited in the Dermis

(2009) Vincent Flacher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Enhancement of anti-tumor immunity by high levels of Th1 and Th17 with a combination of dendritic cell fusion hybrids and regulatory T cell depletion in pancreatic cancer

(2009) Kamigaki   ONCOLOGY REPORTS

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions

(2009) K. Nagao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Analysis of Dendritic Cell Development and Homeostasis

(2009) K. Liu et al.   SCIENCE

In Situ Regulation of DC Subsets and T Cells Mediates Tumor Regression in Mice

(2009) O. A. Ali et al.   Science Translational Medicine

Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity

(2009) Michaela Prchal et al.   VACCINE

Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity

(2009) Jennifer A. McWilliams et al.   VACCINE

Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation

(2008) J. Mouries et al.   BLOOD

Effective treatment of spontaneous metastases derived from a poorly immunogenic murine mammary carcinoma by combined dendritic–tumor hybrid vaccination and adoptive transfer of sensitized T cells

(2008) Hidemasa Tamai et al.   CLINICAL IMMUNOLOGY

Mouse xenograft models vs GEM models for human cancer therapeutics

(2008) A. Richmond et al.   Disease Models & Mechanisms

Anti-tumor immunostimulatory effect of heat-killed tumor cells

(2008) Taek Joon Yoon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Expression of Langerin/CD207 reveals dendritic cell heterogeneity between inbred mouse strains

(2008) Vincent Flacher et al.   IMMUNOLOGY

Plasmacytoid dendritic cells induce NK cell–dependent, tumor antigen–specific T cell cross-priming and tumor regression in mice

(2008) Chengwen Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

(2008) David Sancho et al.   JOURNAL OF CLINICAL INVESTIGATION

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE

In vivo anti-tumor effect of hybrid vaccine of dendritic cells and esophageal carcinoma cells on esophageal carcinoma cell line 109 in mice with severe combined immune defi ciency

(2008) Guang-Hua Guo et al.   WORLD JOURNAL OF GASTROENTEROLOGY