Article
Multidisciplinary Sciences
Tsukumi Miwa, Hideki Taguchi
Summary: Research has shown that IbpA down-regulates the expression of multiple heat shock proteins (Hsps) by repressing the translation of the heat shock transcription factor sigma(32), and plays a crucial role in shutting down the heat shock response. These findings reveal an unknown role of IbpA in regulating the heat shock response at the translational level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Veterinary Sciences
Samuel A. Atkin, Abu Saleh Md Moin, Stephen L. Atkin, Alexandra E. Butler
Summary: This study investigated the effects of hypoglycemia on the heat shock-related protein pathway. The results showed that hypoglycemia significantly decreased the expression of HSP90, 70, 27, and ubiquitin proteins, which are important for the protective response against heat stress.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Plant Sciences
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han
Summary: Aspirin can partially alleviate vascular smooth muscle cell (VSMC) calcification by regulating the expression of heat shock protein 70 (HSP70) and heat shock protein 90 (HSP90). Blocking HSP70 or HSP90 inhibitors can partially weaken the anti-calcification effect of aspirin.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Plant Sciences
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He
Summary: As global warming intensifies, the earth's average temperature continues to rise. Plants have developed two main mechanisms, the heat stress response and the thermomorphogenesis response, to cope with elevated temperatures. This review summarizes recent progress in understanding these heat-responsive molecular regulatory pathways in plants and discusses future perspectives in this field.
Review
Microbiology
Seongjoon Moon, Soojeong Ham, Juwon Jeong, Heechan Ku, Hyunhee Kim, Changhan Lee
Summary: Temperature is critical for the survival of all living organisms. Bacteria, being unicellular organisms, have evolved sensitive mechanisms to sense and defend against temperature changes. This review focuses on the molecular perspective of cellular changes and bacterial responses, particularly in Escherichia coli, when subjected to temperature shifts.
JOURNAL OF MICROBIOLOGY
(2023)
Article
Environmental Sciences
Shao-Shuai Bi, Milton Talukder, Xue-Tong Sun, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long Li
Summary: This study assessed the neurotoxic effects of chronic cadmium (Cd) exposure on the chicken cerebellum and investigated the expression of genes related to the heat-shock response. The results showed that Cd exposure led to clinical symptoms of ataxia in the chickens, decreased the number of Purkinje cells, and induced degeneration of Purkinje cells. Cd exposure also affected the expression of heat-shock factors and proteins. These findings shed light on the toxic effects of Cd on the cerebellum and provide evidence for the health risks posed by Cd exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Oncology
Stephen C. Frederico, John C. Hancock, Emily E. S. Brettschneider, Nivedita M. Ratnam, Mark R. Gilbert, Masaki Terabe
Summary: The use of immunotherapies for brain tumors has generated excitement, but challenges remain in treating GBM due to its immunologically cold nature. Strategies such as vaccine therapy combined with immune checkpoint inhibitors are being explored to overcome these challenges and enhance treatment options for patients with GBM in the future.
FRONTIERS IN ONCOLOGY
(2021)
Review
Plant Sciences
Fengxia Tian, Xiao-Li Hu, Tao Yao, Xiaohan Yang, Jin-Gui Chen, Meng-Zhu Lu, Jin Zhang
Summary: Global warming poses a threat to plant life, with heat shock response (HSR) playing a crucial role in protecting cellular homeostasis, especially for perennial trees. Understanding the molecular mechanisms of HSR in woody plants is essential for predicting how they will respond to climate changes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Maruhen Amir Datsch Silveira, Fatemeh Khadangi, Sofiane Yacine Mersaoui, Divya Naik, Jean-Yves Masson, Steve Bilodeau
Summary: Cells respond to multiple signals from the environment, with crosstalk between pathways affecting their ability to adapt. Chaperones, like HSP70, play a central role in integrating these responses. This study reveals a new crosstalk mechanism between the heat shock and steroid response pathways, mediated by HSP70, which is important for transcriptional regulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Plant Sciences
Hyung-Eun Kim, Jong-Eun Han, Hosakatte Niranjana Murthy, Hyuk-Joon Kwon, Gun-Myung Lee, So-Young Park
Summary: This study evaluated the heat tolerance of ten clones of Cnidium officinale from Korea and identified two heat-tolerant clones that can be used for further evaluation and cultivation.
Review
Toxicology
Benjamin J. Lang, Martin E. Guerrero, Thomas L. Prince, Yuka Okusha, Cristina Bonorino, Stuart K. Calderwood
Summary: Cells respond to protein-damaging stress by activating the Heat Shock Response (HSR), which plays a crucial role in determining cell survival or death. The modulation of HSR and its network have become attractive treatment strategies for neurodegenerative diseases and cancers. A detailed understanding of the mechanisms of HSR is necessary for the development of effective therapies, as important features of HSR continue to be uncovered.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Engineering, Biomedical
Yan-Wei Wu, Wan-Yu Wang, Yu-Hung Chen
Summary: This study demonstrates that a positively charged nanocomplex can drive the Th1 immune response and modulate dendritic cell differentiation. The surface charge and size of the nanocomplex were found to affect the immune response. Furthermore, vaccination with the positively charged nanocomplex was shown to increase specific antibody and memory T-cell responses.
MATERIALS TODAY BIO
(2022)
Article
Parasitology
Nancy A. Aguoru, Ruth S. Kirk, Anthony J. Walker
Summary: This study provides a detailed molecular bioinformatic analysis of heat shock proteins (HSPs) in the human parasitic blood fluke Schistosoma mansoni. The results reveal the classification, expression patterns, protein interactions, and phosphorylation sites of HSPs in different stages of the parasite's life cycle. The findings suggest that HSPs play important roles in parasite survival and development, and offer insights for future investigations and therapeutics development against schistosomiasis.
PARASITES & VECTORS
(2022)
Review
Biochemistry & Molecular Biology
Ayush Ranawade, Rati Sharma, Erel Levine
Summary: The Heat Shock Response (HSR) is a conserved genetic system that protects the proteome in organisms. Mathematical modeling has been crucial in understanding its regulation, but there are still many unanswered questions that can benefit from quantitative modeling.
Article
Immunology
Nicholas J. Shields, Estelle M. Peyroux, Katrin Campbell, Sunali Mehta, Adele G. Woolley, Claudio Counoupas, Silke Neumann, Sarah L. Young
Summary: Proteases released from dying cells can degrade antigens and generate proteolytic intermediates that enhance immune cell responses.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Jianfeng Cui, Lixin Wang, Xiangmin He, Victor Hugo C. De Albuquerque, Salman A. AlQahtani, Mohammad Mehedi Hassan
Summary: Feature extraction plays a crucial role in arrhythmia classification. This paper presents a feature extraction method that combines traditional approaches and 1D-CNN to improve the accuracy of arrhythmia classification. Experimental results show that the proposed method achieves an average classification accuracy of 98.35%, surpassing the latest methods.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Business, Finance
M. Kabir Hassan, Md Iftekhar Hasan Chowdhury, Faruk Balli, Rashedul Hasan
Summary: This study uncovers the impact of COVID-19 on Islamic equity markets compared to conventional markets. Islamic markets show relative resilience in the face of the pandemic, with both Islamic and non-Islamic Asian markets recovering faster than other regions. The study also reveals a positive correlation between higher returns and smaller drawdowns, as well as higher volatility and larger drawdowns. Despite the large-scale drawdown, some Islamic markets outperform their conventional counterparts. Overall, this study reinforces the view that Islamic markets are more resilient during crisis periods.
FINANCE RESEARCH LETTERS
(2022)
Article
Polymer Science
Yara Elgawady, Deepalekshmi Ponnamma, Mohammad K. Hassan, Samer Adham, Alamgir Karim, Mariam Al Ali Al-Maadeed
Summary: This study synthesized silver nanoparticles using silver nitrate and sodium bromide precursors, and in situ synthesized polysulfone-poly(ethylene-glycol) block copolymer in the presence of silver. The resulting nanocomposite exhibited improved mechanical properties and thermal stability, with the silver nanoparticles reinforcing the material. The electrospun fibers of the nanocomposite showed enhanced wettability, making it suitable for oil/water emulsion separation applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Plant Sciences
Maria Batool, Ali Mahmoud El-Badri, Muhammad Umair Hassan, Yang Haiyun, Wang Chunyun, Yan Zhenkun, Kuai Jie, Bo Wang, Guangsheng Zhou
Summary: Drought poses serious threats to global crop production, including oilseed crops like Brassica napus L. Various approaches have been used to increase drought tolerance, but there is room for further improvement. Future research should focus on developing genetically engineered rapeseed plants with enhanced drought tolerance.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Medicine, General & Internal
Md Abul Kalam, Shahanaj Shano, Sharmin Afrose, Md Nasir Uddin, Nafis Rahman, Faruk Ahmed Jalal, Samira Akter, Ariful Islam, Md Mujibul Anam, Mohammad Mahmudul Hassan
Summary: This study examines the seeking and consumption behaviors of antibiotics from the perspective of users in Bangladesh during the COVID-19 pandemic. The findings suggest that antibiotic seeking and usage are influenced by various factors including previous experience, perceived severity of illness, risk of infection, anxiety, distrust of expert advice, and intrinsic agency on antimicrobial resistance. Suboptimal adherence and early cessation of therapy were also observed.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Article
Business, Finance
Md Bokhtiar Hasan, M. Kabir Hassan, Md Mamunur Rashid, Md Sumon Ali, Md Naiem Hossain
Summary: The study evaluates seven calendar anomalies in both conventional and Islamic stock indices of Bangladesh, finding most anomalies present in either index except for the Ramadan effect. Significant differences between the two indices, particularly in volatility, suggest that market efficiency may be challenged.
MANAGERIAL FINANCE
(2022)
Article
Ophthalmology
Muhammad Hassan, Mohammad Ali Sadiq, Maria Soledad Ormaechea, Gunay Uludag, Muhammad Sohail Halim, Rubbia Afridi, Diana Do, Yasir Jamal Sepah, Quan Dong Nguyen
Summary: Intravenous tocilizumab showed efficacy in improving or maintaining stability in patients with non-infectious uveitis when assessed using a composite endpoint scoring system.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Computer Science, Hardware & Architecture
Md Golam Rabiul Alam, Abde Musavvir Khan, Myesha Farid Shejuty, Syed Ibna Zubayear, Md Nafis Shariar, Meteb Altaf, Mohammad Mehedi Hassan, Salman A. AlQahtani, Ahmed Alsanad
Summary: This paper proposes an automated Ejection Fraction estimation system from 2D echocardiography images using deep semantic segmentation neural networks. Two parallel pipelines of deep semantic segmentation neural network models have been proposed for efficient left ventricle segmentation, and three different neural networks, UNet, ResUNet, and Deep ResUNet, have been implemented. The most accurate model achieved high Dice scores for left ventricle segmentation in both systolic and diastolic states. The proposed system can remove the eyeball estimation practice and reduce inter-observer variability.
JOURNAL OF SUPERCOMPUTING
(2023)
Article
Computer Science, Information Systems
Muhammad Umair Hassan, Dongmei Niu, Mingxuan Zhang, Xiuyang Zhao
Summary: This research proposes a novel asymmetric learning-based generative adversarial network (AGAN) for image retrieval, integrating feature learning with hashing and introducing three loss functions that significantly improve retrieval performance.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Engineering, Civil
Kashif Naseer Qureshi, Gwanggil Jeon, Mohammad Mehedi Hassan, Md. Rafiul Hassan, Kuljeet Kaur
Summary: Intelligent Transportation Systems (ITS) have gained popularity due to their smart services, but the increasing number of users has raised concerns over data processing, storage, security, and privacy. To address these concerns, this paper proposes a Blockchain-based Privacy-Preserving Authentication (BPPAU) model that uses smart contracts, access control policies, and on-demand functions to manage data while maintaining user privacy. The model's performance is evaluated through simulation tests analyzing transaction cost, transaction per second, and computational time with various data sizes and block times.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Civil
Jia Hu, Kuljeet Kaur, Hui Lin, Xiaoding Wang, Mohammad Mehedi Hassan, Imran Razzak, Mohammad Hammoudeh
Summary: This paper proposes a Transfer Learning based Trajectory Anomaly Detection strategy, named TLTAD, for IoT-empowered Maritime Transportation Systems (IoT-MTS). Experimental results show that TLTAD can accurately detect anomalies in ships' trajectories and reduce model training time.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Civil
Peng Xu, Ke Wang, Mohammad Mehedi Hassan, Chien-Ming Chen, Weiguo Lin, Md Rafiul Hassan, Giancarlo Fortino
Summary: This paper employs a One-Shot Neural Architecture Search (NAS) to generate derivative models with different scales and studies the relationship between network sizes and model robustness. The experimental results show that reducing model parameters can increase model robustness under maximum adversarial attacks, while increasing model parameters can enhance model robustness under minimum adversarial attacks. This analysis helps to understand the adversarial robustness of models with different scales for edge AI transportation systems.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Civil
Prabhat Kumar, Govind P. Gupta, Rakesh Tripathi, Sahil Garg, Mohammad Mehedi Hassan
Summary: The recent growth of IoT technologies in the maritime industry has digitalized Maritime Transportation Systems (MTS), but also introduced cybersecurity threats. Cyber Threat Intelligence (CTI) is an effective security strategy, but existing solutions have low detection rates and high false alarm rates. To address these challenges, an automated framework called DLTIF has been proposed, which can accurately identify threat types.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Civil
Xiaoding Wang, Sahil Garg, Hui Lin, Georges Kaddoum, Jia Hu, Mohammad Mehedi Hassan
Summary: This paper proposes a hierarchical trust evaluation strategy based on heterogeneous blockchain, utilizing federated deep learning technology for Intelligent Transportation Systems (ITS) security.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Biochemistry & Molecular Biology
Anas Shamsi, Debarati DasGupta, Fahad A. Alhumaydhi, Mohd Shahnawaz Khan, Suliman A. Alsagaby, Waleed Al Abdulmonem, Md. Imtaiyaz Hassan, Dharmendra Kumar Yadav
Summary: This study investigates the inhibition of MARK4 by serotonin through combined computational and experimental studies. The results demonstrate the direct physical binding of serotonin to MARK4 and subsequent inhibition of its kinase activity. Molecular docking and MD simulations further confirm the stability of the MARK4-serotonin complex. Given the potential of MARK4 as a drug target for cancer and neurodegenerative disorders, these findings are of significant interest for drug design and discovery.
RSC MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)
