Review
Immunology
Mahdi Abdoli Shadbad, Khalil Hajiasgharzadeh, Afshin Derakhshani, Nicola Silvestris, Amir Baghbanzadeh, Vito Racanelli, Behzad Baradaran
Summary: Although melanoma remains the deadliest skin cancer, immunotherapy has provided more tolerable approaches and revolutionized cancer therapy. However, the undesirable response rates of traditional approaches and the immunosuppressive tumor microenvironment have raised questions about their clinical translation. Additional research on oncogenic pathways and novel tumor antigens is essential for developing more effective dendritic cell-based vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ivan Y. Y. Filin, Yuri P. P. Mayasin, Chulpan B. B. Kharisova, Anna V. Gorodilova, Kristina V. V. Kitaeva, Daria S. S. Chulpanova, Valeriya V. V. Solovyeva, Albert A. A. Rizvanov
Summary: Melanoma is a highly aggressive and therapy-resistant cancer, with increasing incidence rates. Conventional methods of treatment often result in relapse. Adjuvant therapies, such as cell-based immunotherapy, can be used to reduce recurrence risk by mobilizing the immune system to kill cancer cells. This review discusses the advantages, challenges, and ongoing clinical trials of cell-based therapy for adjuvant treatment of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Nils Scheib, Jessica Tiemann, Christian Becker, Hans Christian Probst, Verena Katharina Raker, Kerstin Steinbrink
Summary: This review discusses the important role of dendritic cells in initiating and regulating immune responses. It focuses on the changes in dendritic cells in skin diseases and the potential for therapeutic reprogramming. The interactions with regulatory T cells are also highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mary Jo Rademacher, Anahi Cruz, Mary Faber, Robyn A. A. Oldham, Dandan Wang, Jeffrey A. Medin, Nathan J. Schloemer
Summary: Lentiviral transduction of sarcoma cells to express IL-12 can induce high-level expression of IL-12 and elicit specific immune responses in murine models, particularly mature human NK cells. IL-12 immunomodulation through autologous tumor transduction and reintroduction shows promise for sarcoma treatment and warrants further exploration.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Bas D. Koster, Marta Lopez Gonzalez, Mari Fcm van den Hout, Annelies W. Turksma, Berbel J. R. Sluijter, Barbara G. Molenkamp, Paul A. M. van Leeuwen, Saskia Vosslamber, Rik J. Scheper, Alfons J. M. van den Eertwegh, M. Petrousjka van den Tol, Ekaterina J. Jordanova, Tanja D. de Gruijl
Summary: Injection of CpG-B at the primary tumor excision site prior to re-excision and sentinel node biopsy leads to increased recruitment and activation of antigen-presenting cell (APC) subsets in the skin, particularly CD83(+), CD14(+), CD68(+), and CD123(+) APC in the reticular dermis. This recruitment is correlated with T cell infiltration, specifically with cDC1 and CD14(+) APC counts. These findings suggest a role for CpG-induced cDC1 and CD14(+) APC activation in promoting T cell infiltration through CXCL10 release.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Anastasia Prokopi, Christoph H. Tripp, Bart Tummers, Florian Hornsteiner, Sarah Spoeck, Jeremy Chase Crawford, Derek R. Clements, Mirjana Efremova, Katharina Hutter, Lydia Bellmann, Giuseppe Cappellano, Bruno L. Cadilha, Sebastian Kobold, Louis Boon, Daniela Ortner, Zlatko Trajanoski, Suzie Chen, Tanja D. de Gruijl, Juliana Idoyaga, Douglas R. Green, Patrizia Stoitzner
Summary: Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but many still do not benefit from this treatment due to factors such as lack of tumor-infiltrating T cells and loss of intratumoral dendritic cells. In a melanoma mouse model, researchers found that tumor progression is characterized by upregulation of checkpoint molecules and gradual loss of dermal conventional DC 2 subset. Monotherapy with checkpoint blockade was not effective, but boosting DC numbers and activation increased tumor immunogenicity, leading to improved T cell function and delayed tumor growth when combined with antibodies against PD-1 and TIM-3. The study highlights the importance of skin DC in cancer immunotherapy and suggests that restoring DC function is key to enhancing tumor immunogenicity and responsiveness to checkpoint blockade therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Jiemiao Hu, Qing Yang, Wendong Zhang, Hongwei Du, Yuhui Chen, Qingnan Zhao, Long Dao, Xueqing Xia, Fowlkes Natalie Wall, Zhongting Zhang, Kris Mahadeo, Richard Gorlick, S. Kopetz, Gianpietro Dotti, Shulin Li
Summary: This study developed a safe IL-12-based T-cell therapy approach for large solid tumors. AttIL12-T cells showed remarkable antitumor efficacy by targeting tumor cells expressing vimentin, activating secondary T-cell responses and tumor antigen spreading, and eliminating peripheral cytokine release and toxic effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, Research & Experimental
Jessica Wenthe, Emma Eriksson, Ann-Charlotte Hellstroem, Rafael Moreno, Gustav Ullenhag, Ramon Alemany, Tanja Lovgren, Angelica Loskog
Summary: LOAd732 is a novel immunostimulatory gene therapy based on an oncolytic adenovirus that activates dendritic cells and stimulates T and NK cells to mediate anti-tumor immune response. This therapy can effectively work in the tumor microenvironment, even under immunosuppressive conditions commonly present.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Katarzyna Wegierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygiel, Joanna Rossowska, Anna Wroblewska, Marta Switalska, Tomasz M. Goszczynski, Bozena Szermer-Olearnik, Elzbieta Pajtasz-Piasecka
Summary: This study aimed to determine whether administering HES-MTX before immunotherapy with anti-IL-10R antibodies would change the effectiveness of dendritic cell vaccines that overproduce proinflammatory cytokines IL-12, IL-15, or IL-18. The results showed that using the HES-MTX nanoconjugate created optimal conditions for the effective action of these vaccines in a murine colon carcinoma model. The treatment schedule may be promising in anticancer therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shumin Luo, Jing Chen, Fang Xu, Huan Chen, Yiru Li, Weihua Li
Summary: This article summarizes a new approach in cancer immunotherapy, which is based on the exosomes derived from dendritic cells (DEXs). DEXs have the potential to improve therapeutic outcomes and overcome tumor cell-mediated immunosuppression. By capturing tumor antigens and promoting immune cell-dependent tumor rejection, DEXs play an important role in enhancing immune responses and overcoming immune escape by tumors.
Article
Chemistry, Multidisciplinary
Cao Dai Phung, Tuan Hiep Tran, Hanh Thuy Nguyen, Tien Tiep Nguyen, Jee-Heon Jeong, Sae Kwang Ku, Chul Soon Yong, Han-Gon Choi, Jong Oh Kim
Summary: Efforts in developing cancer vaccines have faced challenges, but a new artificial nanovaccine targeting lymphatic dendritic cells shows promise in boosting immune response and controlling immunosuppression simultaneously. By incorporating IL-10 siRNA to inhibit suppressive cytokine secretion and utilizing a CD205 antibody for enhanced dendritic cell targeting, the nanovaccine demonstrates potential for enhancing antitumor immunity.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Rasheid Smith, Emad Wafa, Sean M. Geary, Kareem Ebeid, Suhaila O. Alhaj-Suliman, Aliasger K. Salem
Summary: Nanoscale formulations can enhance the efficacy of cancer vaccines by combating the immunosuppressive nature of the tumor microenvironment. A newly synthesized nanoparticulate formulation demonstrated adjuvant properties in vivo, leading to increased TAA-specific T cells, reduced tumor burden, protection against tumor rechallenge, and improved median survival in tumor-challenged mice.
Article
Oncology
Alexander Muik, Homer C. Adams, Friederike Gieseke, Isil Altintas, Kristina B. Schoedel, Jordan M. Blum, Bianca Sanger, Saskia M. Burm, Eliana Stanganello, Dennis Verzijl, Vanessa M. Spires, Fulvia Vascotto, Aras Toker, Juliane Quinkhardt, Mark Fereshteh, Mustafa Diken, David P. E. Satijn, Sebastian Kreiter, Tahamtan Ahmadi, Esther C. W. Breij, Ozlem Tureci, Kate Sasser, Ugur Sahin, Maria Jure-Kunkel
Summary: DuoBody-CD40x4-1BB is a novel antibody capable of enhancing antitumor immunity by modulating the functions of immune cells. In vitro and in vivo experiments have demonstrated its ability to enhance dendritic cell and T-cell functions, as well as its biological activity in patients with advanced solid tumors. These findings suggest that targeting CD40 and 4-1BB with an Fc-inert bispecific antibody may be an effective approach for cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Xin-Wen Zhang, Katrin Huck, Kristine Jaehne, Frederik Cichon, Jana K. Sonner, Friederike Ufer, Simone Bauer, Marcel Seungsu Woo, Ed Green, Kevin Lu, Michael Kilian, Manuel A. Friese, Michael Platten, Katharina Sahm
Summary: DC vaccination is an effective adjuvant for cancer immunotherapies, and enhancing DC migration towards the tumor microenvironment could increase therapeutic efficacy. Expression of Arc/Arg3.1 facilitates DC migration towards tumors and shapes the tumor immune microenvironment, suggesting it as a potential novel therapeutic target for improving DC vaccine efficacy.
Article
Multidisciplinary Sciences
Douglas S. Jones, Jonathan D. Nardozzi, Katharine L. Sackton, Gulzar Ahmad, Esben Christensen, Lars Ringgaard, De-Kuan Chang, Ditte E. Jaehger, Jacob Konakondla, Martin Wiinberg, Katherine L. Stokes, Alvin Pratama, Karsten Sauer, Thomas L. Andresen
Summary: This study demonstrates a novel approach to safely enhance the efficacy of cancer immunotherapy by tethering immune-activating cytokines onto adoptively transferred cells. The tethered cytokines reshape the tumor immune microenvironment and promote antitumor activity.
Article
Engineering, Biomedical
Ibtehaj Naqvi, Nicholas Giroux, Lyra Olson, Telmo Llanga, Tolu O. Akinade, Yuefei Zhu, Yiling Zhong, Shree Bose, Stephanie Arvai, Karen Abramson, Lingye Chen, Loretta Que, Bryan Kraft, Xiling Shen, Jaewoo Lee, Kam W. Leong, Smita K. Nair, Bruce Sullenger, Sarah Anh Morrison
Summary: It has been found that severely ill COVID-19 patients in the ICU display a hyper-stimulation of TLR signaling, with nucleic acid-sensing TLR agonists present in their blood and lungs. CD16+ monocytes from deceased ICU patients show a TLR-tolerant phenotype and a deficient anti-viral response. Treatment with MnO nanoparticles effectively neutralizes TLR activation by nucleic acid-containing DAMPs/PAMPs in the lungs and blood.
Letter
Oncology
Justin T. Low, Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, Rebecca Fuller, Zachary J. Reitman, Andrea M. Muscat, Seethalakshmi Hariharan, Janell Hostettler, Sarah Danehower, Ali Baker, Mustafa Khasraw, Nicholas C. Wong, Simon Gregory, Smita K. Nair, Amy Heimberger, Matthias Gromeier, Darell D. Bigner, David M. Ashley
Letter
Pediatrics
Rajeev Kumar Thapar, Smita Nair
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Chemistry, Multidisciplinary
Garrett Kelly, Joshua J. Milligan, Eric M. Mastria, Sarah Kim, Stephanie R. Zelenetz, Jarrett Dobbins, Leon Y. Cai, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti
Summary: Combining radiotherapy and immunotherapy using biomaterial-based approaches can effectively improve the outcomes of metastatic cancer treatment. This study developed an injectable depot that can continuously deliver a radionuclide and an immunostimulant to the tumor, leading to controlled tumor growth and distant metastasis. The results showed that this combination therapy had a synergistic effect and significantly improved mouse survival.
JOURNAL OF CONTROLLED RELEASE
(2022)
Editorial Material
Oncology
Austin M. Eckhoff, Ashley A. Fletcher, Karenia Landa, Matthew Iyer, Daniel P. Nussbaum, Chanjuan Shi, Smita K. Nair, Peter J. Allen
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Austin M. Eckhoff, Ashley A. Fletcher, Karenia Landa, Matthew Iyer, Daniel P. Nussbaum, Chanjuan Shi, Smita K. Nair, Peter J. Allen
Summary: The immune infiltrate in IPMN consists mainly of T cells and macrophages. Regions of high-grade dysplasia (HGD) appear to have relatively fewer T cells and a trend towards macrophage enrichment compared to regions of low-grade dysplasia (LGD).
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Corrine A. Nief, Alana Gonzales, Erika Chelales, Julia Sroda Agudogo, Brian T. Crouch, Smita K. Nair, Nirmala Ramanujam
Summary: In the study, it was found that pre-treating tumors with sodium bicarbonate and low-dose cyclophosphamide, followed by tumor ablation, can elicit an anti-tumor immune response in TNBC models. The treatment showed significant therapeutic effects and induced immune memory.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Ericka Chorniak, Yang Liu, Ren Odion, Wiguins Etienne, Aidan Canning, Smita K. Nair, Paolo Maccarini, Gregory M. Palmer, Brant A. Inman, Tuan Vo-Dinh
Summary: Bladder cancer is a common cancer with a high proportion of late stage diagnoses. This study developed a novel treatment for bladder cancer using a combination of gold nanostar-mediated photothermal therapy and checkpoint inhibitor immunotherapy. The results showed that this combined therapy was more effective than individual treatments. The study also used intravital optical imaging to investigate immune responses and immune cell accumulation in distant tumors following the treatment. The findings suggest that intravital optical imaging is an efficient tool for studying the mechanisms of photoimmunotherapy.
Article
Immunology
Aaron D. Therien, Georgia M. Beasley, Kristen E. Rhodin, Norma E. Farrow, Douglas S. Tyler, David Boczkowski, Rami N. Al-Rohil, Eda K. Holl, Smita K. Nair
Summary: This study aimed to explore the differences in the histologic location and activation status of B cell follicles in sentinel lymph nodes of melanoma patients. The findings suggest that B cell follicles play a role in coordinating effective adaptive immune responses in melanoma when low volume metastatic disease is present in tumor draining lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Georgia M. Beasley, Michael C. Brown, Norma E. Farrow, Karenia Landa, Rami N. Al-Rohil, Maria Angelica Selim, Aaron D. Therien, Sin-Ho Jung, Junheng Gao, David Boczkowski, Eda K. Holl, April K. S. Salama, Darell D. Bigner, Matthias Gromeier, Smita K. Nair
Summary: In patients with melanoma, those who had intratumoral inflammation and immune cell infiltrates after anti-PD-1 therapy and lerapolturev treatment had a longer progression-free survival, and they also exhibited stronger immune responses in peripheral blood.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Meeting Abstract
Oncology
Austin Eckhoff, Ashley Fletcher, Matthew Iyer, Chanjuan Shi, Daniel Nussbaum, Smita Nair, Peter Allen
ANNALS OF SURGICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Kristen E. Rhodin, Danielle Bello, Norma Farrow, Paul Mosca, April K. Salama, Smita Nair, Douglas Tyler, Charlotte Ariyan, Georgia Beasley
ANNALS OF SURGICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Aaron D. Therien, Eda K. Holl, Rami Al-Rohil, Kristen E. Rhodin, Douglas Tyler, Smita Nair, Georgia Beasley
ANNALS OF SURGICAL ONCOLOGY
(2022)
Meeting Abstract
Critical Care Medicine
Aditya Mohan, Lyra Olson, Ibtehaj Naqvi, Sarah Morrison, Bryan Kraft, Lingye Chen, Smita Nair, Bruce Sullenger, George Kasotakis
CRITICAL CARE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Camille Robinson, Maria M. Xu, Smita K. Nair, Georgia M. Beasley, Kristen E. Rhodin
Summary: Malignant melanoma recurrence can present in various ways, requiring personalized management. Oncolytic viruses can stimulate local immune response and potentially overcome anti-PD-1 therapy resistance. Currently, one oncolytic virus is FDA-approved for this population, with other viruses under investigation.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)