☆ 4.5 Article

CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice

VACCINE (2014)

Journal

VACCINE

Volume 32, Issue 11, Pages 1229-1232

Publisher

ELSEVIER SCI LTD

DOI: 10.1016/j.vaccine.2014.01.025

Keywords

CD207(+) cells; Dendritic cells; Vaccine; Ectopic lymphoid tissue; Melanoma

Categories

Immunology Medicine, Research & Experimental

Funding

University of Buenos Aires
Agencia Nacional de Promocion Cientifica y Tecnologica [PICT0010]
CONICET

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Abstract

De nova ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207(+) cells to vaccination site. The time-course behavior of CD207(+) cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207(+) cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c((-)) CD207(+) population, whose role remains to be determined. Whether CD207(+) cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. (C) 2014 Elsevier Ltd. All rights reserved.

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