Article
Medicine, Research & Experimental
M. Hope Robinson, Nancy Y. Villa, David L. Jaye, Ajay K. Nooka, Alyssa Duffy, Samuel S. McCachren, Julia Manalo, Jeffrey M. Switchenko, Sierra Barnes, Sayalee Potdar, Maryam I. Azeem, Ava A. Horvat, Vaunita C. Parihar, Jingjing Gong, Yan Liang, Geoffrey H. Smith, Vikas A. Gupta, Lawrence H. Boise, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Summary: This study investigates the mechanisms underlying immune infiltration in human multiple myeloma (MM) and its precursor monoclonal gammopathy of undetermined significance (MGUS) using high-dimensional spatial analyses and in vitro and in vivo modeling. The results suggest that MM exhibits clustered tumor growth and spatial heterogeneity with the coexistence of T cell-rich and T cell-sparse regions, as well as areas of T cell exclusion. T cell entry into MM clusters is regulated by agonistic signals and CD2-CD58 interactions, and CLEC9A+ DCs play a role in marking the portals of entry for T cell infiltration.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
Vajiheh Jahani, Mona Yazdani, Ali Badiee, Mahmoud Reza Jaafari, Leila Arabi
Summary: The immunosuppressive tumor microenvironment limits the efficacy of cancer vaccines. Combining liposomal celecoxib with DC vaccines can normalize the tumor microenvironment and enhance the antitumor response.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Immunology
Anne-Charlotte Antoni, Ekaterina Pylaeva, Bettina Budeus, Jadwiga Jablonska, Ludger Klein-Hitpass, Marcel Dudda, Stefanie B. Flohe
Summary: CD8(+) T cells sense TLR2 signals and control the number and function of de novo differentiating DCs in the bone marrow during sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Rasheid Smith, Emad Wafa, Sean M. Geary, Kareem Ebeid, Suhaila O. Alhaj-Suliman, Aliasger K. Salem
Summary: Nanoscale formulations can enhance the efficacy of cancer vaccines by combating the immunosuppressive nature of the tumor microenvironment. A newly synthesized nanoparticulate formulation demonstrated adjuvant properties in vivo, leading to increased TAA-specific T cells, reduced tumor burden, protection against tumor rechallenge, and improved median survival in tumor-challenged mice.
Article
Immunology
James T. T. Gordy, Avinaash K. K. Sandhu, Kaitlyn Fessler, Kun Luo, Aakanksha R. R. Kapoor, Samuel K. K. Ayeh, Yinan Hui, Courtney Schill, Fengyixin Chen, Tianyin Wang, Styliani Karanika, Joel C. C. Sunshine, Petros C. C. Karakousis, Richard B. B. Markham
Summary: The fusion of chemokine MIP-3 alpha gene with melanoma-associated antigen genes in DNA vaccines has shown enhanced anti-tumor immunity. Combination therapy with DNA vaccine, type-I interferon, and 5Aza significantly upregulated intratumoral mRNA expression of immune infiltration chemokines and increased infiltration of CD8+ DCs, CCR7+ DCs, NK cells, and memory T-cells while reducing myeloid-derived suppressor cells. This approach holds promise for melanoma treatment and further studies are needed to understand its mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Alexandra M. Adams, Elizabeth L. Carpenter, Guy T. Clifton, Timothy J. Vreeland, Robert C. Chick, Anne E. O'Shea, Patrick M. McCarthy, Phillip M. Kemp Bohan, Annelies T. Hickerson, Franklin A. Valdera, Ankur Tiwari, Diane F. Hale, John R. Hyngstrom, Adam C. Berger, James W. Jakub, Jeffrey J. Sussman, Montaser F. Shaheen, Xianzhong Yu, Thomas E. Wagner, Mark B. Faries, George E. Peoples
Summary: This study examined the efficacy of the TLPLDC vaccine in patients with melanoma and found that patients who did not receive pretreatment with G-CSF had improved overall survival and disease-free survival. Direct collection of dendritic cells without G-CSF resulted in higher expression of genes associated with dendritic cell maturation, potentially improving clinical efficacy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Immunology
Ye Zheng, Xiaoyu Ma, Shouchang Feng, Hongtao Zhu, Xin Chen, Xingjiang Yu, Kai Shu, Suojun Zhang
Summary: Glioblastoma (GBM), the most malignant subtype of glioma, is resistant to traditional therapies and immunotherapies. Dendritic cell vaccine (DCV) has shown potential as a therapeutic method, but there are challenges to its use.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jingjing Wang, Yu Liu, Weihua Ni, Xinjie Wu, Jianhong Zhou, Zenan Zhang, Hongyue Zhou, Nannan Zhang, Mengyu Jiang, Qianyu Sang, Hongyan Yuan, Guixiang Tai
Summary: This study found that TRAF6 overexpression promotes the maturation of dendritic cells (DCs) and activates Th1 responses. In a therapeutic tumor model, TRAF6-overexpressing DCs significantly inhibited tumor growth and enhanced specific immune responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Chun Fang Hu, Xiao Yan Liao, Dan Dan Xu, Yi Bin Ruan, Feng Guang Gao
Summary: Nicotine treatment increases K48-linked ubiquitination in BM-DC, promoting cross-presentation and CTL priming. K48-linked ubiquitination is crucial for nicotine-enhanced cross-presentation and CTL priming, contributing to the superior cytolytic capacity of DC-activated CTL.
Article
Oncology
Yoke Seng Lee, Liam J. O'Brien, Carina M. Walpole, Frances E. Pearson, Ingrid M. Leal-Rojas, Kelly-Anne Masterman, Victoria Atkinson, Andrew Barbour, Kristen J. Radford
Summary: The study found that the number of CD141(+) dendritic cells in the blood of melanoma patients was significantly reduced, and these cells exhibited impaired function after peripheral stimulation. In non-responding patients, the number and function of these cells continued to decline during treatment. Indirectly expanding and activating CD141(+) dendritic cells in vivo with Flt3L and a TLR3 agonist can enhance the efficacy of anti-PD-1 treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Hematology
Swetha Kambhampati, Ying Sheng, Chiung-Yu Huang, Sophia Bylsma, Mimi Lo, Vanessa Kennedy, Kelsey Natsuhara, Thomas Martin, Jeffrey Wolf, Nina Shah, Sandy W. Wong
Summary: B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy is an effective treatment for relapsed refractory multiple myeloma. This study analyzed the infection outcomes of 55 MM patients treated with BCMA CAR-T and found that despite multiple risk factors, severe infections were relatively rare.
Article
Biochemistry & Molecular Biology
Yasuaki Tamura, Akira Ito, Kazumasa Wakamatsu, Toshihiko Torigoe, Hiroyuki Honda, Shosuke Ito, Kowichi Jimbow
Summary: N-Pr-4-S-CAP is selectively incorporated into melanoma cells and induces CD8(+) T cell-dependent anti-melanoma immunity, leading to the inhibition of melanoma growth. Administration of N-Pr-4-S-CAP could be a potential prophylactic therapy against local recurrence and distant metastasis of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Haiyan Chen, Meng Wu, Hongping Xia, Songjie Du, Guoren Zhou, Guangfeng Long, Yanan Zhu, Xu Huang, Daheng Yang
Summary: This study identified hub genes related to T cell exhaustion and suppression in acute myelocytic leukemia (AML) and explored their correlation with immune activity. Single-cell transcriptome analysis revealed signaling axes involved in the activation of CD4+ and CD8+ T cells. These findings provide insights into the mechanisms of T cell suppression in AML and support the use of immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Soledad Mac Keon, Maria Sol Ruiz, Silvina Gazzaniga, Rosa Wainstok
FRONTIERS IN IMMUNOLOGY
(2015)
Letter
Oncology
M. S. Ruiz, M. Medina, I. Tapia, J. Mordoh, N. C. P. Cross, I. Larripa, M. Bianchini
Article
Immunology
Maria Sol Ruiz, Soledad Mac Keon, Sabrina Campisano, Alicia Ines Bravo, Silvina Gazzaniga, Rosa Wainstok
Article
Medical Laboratory Technology
Maria Sol Ruiz, Maria Belen Sanchez, Yuly Masiel Vera Contreras, Evangelina Agrielo, Marta Alonso, Maria Eugenia Altuna, Maria Sol Anchordoqui, Mariana Asinari, Maria Elisa Bonetto, Mauricio Camargo, Isabel Giere, Javier Gonzalez, Ana Cecilia Granda Alacote, Javier Guerra, Marina Gutierrez, Cecilia Maldonado, Ricardo Makiya, Gonzalo Manrique, Maria Eugenia Monaco, Juan Carlos Rozo, Carlos Santamaria, Analia Seravalle, Olga Zea, Maria Noel Zubillaga, Jose Mordoh, Irene Larripa, Michele Bianchini
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Maria Sol Ruiz, Maria Belen Sanchez, Simone Bonecker, Carolina Furtado, Daniel Koile, Patricio Yankilevich, Santiago Cranco, Maria del Rosario Custidiano, Josefina Freitas, Beatriz Moiraghi, Mariel Ana Perez, Carolina Pavlovsky, Ana Ines Varela, Veronica Ventriglia, Julio Cesar Sanchez avalos, Irene Larripa, Ilana Zalcberg, Jose Mordoh, Peter Valent, Michele Bianchini
Summary: This study analyzed the miRNome of LSC and HSC-enriched fractions from CML patients, revealing a global decrease in microRNA levels and potential silencing of multiple non-coding RNAs. Despite the absence of BCR-ABL1 expression, an altered miRNome was observed in HSC. The findings suggest a potential role of microRNA in metabolic vulnerabilities in LSC and provide valuable data for future studies and therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2021)
Letter
Medical Laboratory Technology
Leandro G. Gutierrez, Miguel M. Abelleyro, Maria Sol Ruiz, Maria Sol Anchordoqui, Josefina Freitas, Michele Bianchini, Carlos D. De Brasi, Irene B. Larripa
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ayelen Toro, Maria Sol Ruiz, Sofia Lage-Vickers, Pablo Sanchis, Agustina Sabater, Gaston Pascual, Rocio Seniuk, Florencia Cascardo, Sabrina Ledesma-Bazan, Felipe Vilicich, Elba Vazquez, Geraldine Gueron
Summary: Heme oxygenase 1 (HO-1) plays a crucial role in maintaining cellular homeostasis and possesses cytoprotective, antioxidative, anti-inflammatory, and antiviral properties. This review highlights the protective role of HO-1 in inflammatory diseases and viral infections, suggesting its potential as a therapeutic target for ameliorating clinical manifestations during COVID-19.
Article
Medicine, General & Internal
Irene Larripa, Maria Sol Ruiz, Marina Gutierrez, Michele Bianchini
MEDICINA-BUENOS AIRES
(2017)