Review
Immunology
Xi Zhang, Tianhui He, Yuan Li, Ling Chen, Hongyu Liu, Yu Wu, Hongyan Guo
Summary: Ovarian cancer is characterized by uncertain presentation and poor outcomes, with surgery and chemotherapy being the current basis of treatment. However, there are limitations due to advanced stage at diagnosis and high recurrence rate. The use of anti-VEGF agents, PARP inhibitors, and immunotherapies are being explored to enhance treatment outcomes, but the population that can benefit from these treatments remains limited.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Vajiheh Jahani, Mona Yazdani, Ali Badiee, Mahmoud Reza Jaafari, Leila Arabi
Summary: The immunosuppressive tumor microenvironment limits the efficacy of cancer vaccines. Combining liposomal celecoxib with DC vaccines can normalize the tumor microenvironment and enhance the antitumor response.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Immunology
Katarzyna Wegierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygiel, Joanna Rossowska, Anna Wroblewska, Marta Switalska, Tomasz M. Goszczynski, Bozena Szermer-Olearnik, Elzbieta Pajtasz-Piasecka
Summary: This study aimed to determine whether administering HES-MTX before immunotherapy with anti-IL-10R antibodies would change the effectiveness of dendritic cell vaccines that overproduce proinflammatory cytokines IL-12, IL-15, or IL-18. The results showed that using the HES-MTX nanoconjugate created optimal conditions for the effective action of these vaccines in a murine colon carcinoma model. The treatment schedule may be promising in anticancer therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yue Liu, Joanna Pagacz, Donald J. Wolfgeher, Kenneth D. Bromerg, Jacob Gorman, Stephen J. Kron
Summary: Antigen presentation may be the limiting factor in the low immune response to radiation therapy, and combining immune checkpoint blockade does not restore cytotoxic T lymphocytes function. Therapeutic vaccines based on senescent tumor cells or SnC-activated dendritic cells have the potential to enhance immune therapies and limit recurrence or metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Harun Achmad, Yousif Saleh Ibrahim, Muataz Mohammed Al-Taee, Gamal A. Gabr, Muhammad Waheed Riaz, Shadia Hamoud Alshahrani, Andres Alexis Ramirez-Coronel, Abduladheem Turki Jalil, Hendrik Setia Budi, Windi Sawitri, Malyutina Elena Stanislavovna, Jitendra Gupta
Summary: Cancer immunotherapy aims to eradicate tumors by stimulating the host's anti-tumor immune response. Cancer vaccines have emerged as a promising approach, either alone or in combination with other therapies. Nanoplatforms, such as nanoparticles, cell-derived components, and nanocomplexes, have been developed to deliver vaccine components to target cells and tissues, thereby enhancing anti-tumor efficacy and reducing side effects. Targeting dendritic cells (DCs) with nanovaccines has attracted significant interest. This review provides an overview of nanovaccines in cancer therapy, with a focus on targeting DCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hong Pan, Hongyan Shi, Peng Fu, Pengfei Shi, Jianyuan Yang
Summary: The folate-modified liposome loaded with chlorin e6 (FA-Lipo-Ce6) can activate dendritic cells and effectively suppress the growth of breast cancers.
Article
Chemistry, Multidisciplinary
Armin Mahmoud Salehi Kheshti, Farnaz Hajizadeh, Asal Barshidi, Bentolhoda Rashidi, Farbod Ebrahimi, Simin Bahmanpour, Vahid Karpisheh, Fatemeh Karimian Noukabadi, Fariba Karoon Kiani, Hadi Hassannia, Fatemeh Atyabi, Seyed Hossein Kiaie, Fatah Kashanchi, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi, Rafieh Bagherifar, Reza Jafari, Naime Majidi Zolbanin, Farhad Jadidi-Niaragh
Summary: This study successfully achieved the goal of inhibiting beta-catenin expression and delivering IL-15 in the tumor microenvironment through the use of a novel nanocarrier, leading to the inhibition of cancer cell growth and enhancement of immune response. The treatment also improved the performance of the DC vaccine, resulting in tumor inhibition and increased survival in mice. These findings suggest that new nanocarriers could be an effective approach for cancer treatment.
PHARMACEUTICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Giulia Agliardi, Anna Rita Liuzzi, Alastair Hotblack, Donatella De Feo, Nicolas Nunez, Cassandra L. Stowe, Ekaterina Friebel, Francesco Nannini, Lukas Rindlisbacher, Thomas A. Roberts, Rajiv Ramasawmy, Iwan P. Williams, Bernard M. Siow, Mark F. Lythgoe, Tammy L. Kalber, Sergio A. Quezada, Martin A. Pule, Sonia Tugues, Karin Straathof, Burkhard Becher
Summary: Research shows that local delivery of IL-12 combined with CAR-T cell therapy can achieve durable anti-tumor responses by enhancing cytotoxicity of CAR-T cells, reshaping the tumor microenvironment, promoting immune cell infiltration, and activating the myeloid compartment.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Emily M. Cheng, Noah W. Tsarovsky, Paul M. Sondel, Alexander L. Rakhmilevich
Summary: This review discusses the research progress and findings of using IL-12 in combination with other cancer treatment modalities. It highlights the potential of an in situ vaccination approach to minimize toxicities and provide antitumor efficacy. It also suggests the integration of IL-12 as an immunotherapy into the clinical treatment of cancers.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Oncology
Julia Katharina Schwarze, Xenia Geeraerts, Sandra Tuyaerts, Bart Neyns
Summary: This review highlights the unique role of dendritic cells (DCs) in cancer and discusses how specific subsets of DCs can be manipulated to induce an effective and durable antitumor response.
CURRENT OPINION IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Marisa E. Aikins, You Qin, Hannah E. Dobson, Alireza Hassani Najafabadi, Kexing Lyu, Yao Xu, Ying Xin, Anna Schwendeman, Max S. Wicha, Alfred E. Chang, Qiao Li, James J. Moon
Summary: One major obstacle in cancer treatment is the presence of cancer stem cells (CSCs), which are resistant to traditional therapies and contribute to metastasis and relapse. In this study, a therapeutic vaccine targeting CSCs in melanoma was developed and shown to effectively reduce tumor growth and improve survival. The vaccine stimulated strong T cell responses against CSC-associated antigens and promoted infiltration of CD8+ T cells into tumors, while reducing the frequency of CSCs. This approach represents a safe and cost-effective strategy for targeting and eliminating CSCs in melanoma and other types of cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Yunkai Yang, Xiaohan Guo, Bo Hu, Peng He, Xiaowu Jiang, Zuohuan Wang, Huaxing Zhu, Lina Hu, Minghua Yu, Meiqing Feng
Summary: The fusion protein SNU containing SecPen and ubiquitin-fused NY-ESO-1 loaded onto dendritic cells can elicit stronger and specific T cell immune responses, resulting in increased cytotoxicity towards MC38(NY-ESO-1) tumor cells.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Immunology
Dieter Stevens, Joline Ingels, Sandra Van Lint, Bart Vandekerckhove, Karim Vermaelen
Summary: Immune therapy plays a significant role in the treatment of lung cancer patients, with potential for further exploration. Combining immune checkpoint blockade with other strategies may be a way to fully harness the immune system's anti-tumor potential. Dendritic cells, with their unique ability to initiate and regulate T cell responses, show promise as tools for immunotherapy in lung cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sarah I. M. Sutherland, Xinsheng Ju, L. G. Horvath, Georgina J. Clark
Summary: Despite the success of using checkpoint inhibitors to reprim T cells to recognize tumors in certain malignancies, including melanoma, lung, and renal cell carcinoma, many tumors, such as prostate cancer, remain resistant to such treatment. DC-based immunotherapy, such as Sipuleucel-T, has shown improved overall survival in prostate cancer, but further research into DC vaccines has been limited. Understanding the immunosuppressive environment of prostate cancer and developing new vaccine strategies that can overcome this environment is essential for future success in immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Zacharias Wijfjes, Floris J. van Dalen, Camille M. Le Gall, Martijn Verdoes
Summary: This article reviews the mouse and human receptors studied as targets for therapeutic vaccines and discusses how antibody and ligand conjugates targeting affect antigen presentation. The aim is to delineate how targeting distinct receptors affects antigen presentation and vaccine efficacy, guiding target selection for future therapeutic vaccine development.
MOLECULAR PHARMACEUTICS
(2023)
Article
Medicine, General & Internal
Piotr Zapala, Aleksander Slusarczyk, Pawel Rajwa, Mikolaj Przydacz, Wojciech Krajewski, Bartosz Dybowski, Przemyslaw Kubik, Blazej Kuffel, Maciej Przudzik, Rafal Osiecki, Remigiusz Stamirowski, Lukasz Zapala, Mieszko Kozikowski, Dominik Choragwicki, Magdalena Szymanska, Pawel Kielb, Bartosz Malkiewicz, Jacek Zostawa, Marek Roslan, Joanna Zajaczkowska, Marcin Jarzemski, Bartosz Brzoszczyk, Piotr Petrasz, Piotr Jarzemski, Romuald Zdrojowy, Jakub Dobruch, Andrzej Paradysz, Tomasz Drewa, Piotr Radziszewski, Piotr Chfosta
Summary: In Poland, the COVID-19 pandemic has led to a reduction in urooncological surgeries, specifically for TURBT and PN, while RC surgeries have significantly increased.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Oncology
Lukasz Zapala, Michal Kunc, Sumit Sharma, Rafal Peksa, Marta Popeda, Wojciech Biernat, Piotr Radziszewski
Summary: This study evaluated the expression of PD-L1 in venous tumor thrombus and primary tumor, and found that it was associated with overall survival in patients. The best prognostic performance was observed when PD-L1 expression was assessed in venous tumor thrombus using the 22c3 antibody.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Zapala, Aleksander Slusarczyk, Rafal Wolanski, Pawel Kurzyna, Karolina Garbas, Piotr Zapala, Piotr Radziszewski
Summary: This study aimed to determine the relevance of comorbidities and selected inflammatory markers to the survival of patients with primary non-metastatic localized clear cell renal cancer. The study found that tumor stage, grade, size, and selected hematological markers were significant predictors of survival, and the model developed in this study outperformed existing prognostic tools in terms of accuracy.
Article
Oncology
Lukasz Zapala, Michal Kunc, Sumit Sharma, Rafal Peksa, Marta Popeda, Wojciech Biernat, Piotr Radziszewski
Summary: This study aimed to investigate the expression of VISTA and TOX within venous tumor thrombus and primary ccRCC, and evaluate their prognostic value. It was found that the expression of TOX was positively correlated with the percentage of VISTA-positive TAICs in venous thrombus, and high TOX expression was associated with a higher percentage of PD-L1-positive TAICs in both compartments. Positive expression of VISTA on TAICs was associated with PD-L1 expression on TCs and TAICs in the primary tumor, and only with PD-L1 on TAICs in thrombus. The presence of VISTA-positive TAICs in venous thrombus was significantly more common in females, and correlated with metastases and tumor necrosis. Furthermore, patients with VISTA-positive TAICs in venous tumor thrombi had significantly shorter overall survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Aleksander Slusarczyk, Piotr Zapala, Lukasz Zapala, Piotr Radziszewski
Summary: Smoking is associated with a higher risk of recurrence and progression in non-muscle invasive bladder cancer (NMIBC) patients. Smoking has a detrimental effect on the survival rate of recurrence and progression in NMIBC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Piotr Zapala, Karolina Garbas, Zbigniew Lewandowski, Aleksander Slusarczyk, Cezary Slusarczyk, Lukasz Mielczarek, Giancarlo Marra, Benjamin Pradere, Pawel Rajwa, Lukasz Zapata, Piotr Radziszewski
Summary: The study aimed to determine the clinical utility of neutrophil-to-lymphocyte ratio (NLR) in predicting nodal involvement in prostate cancer patients treated with radical prostatectomy. The retrospective study included 205 patients and found that higher NLR was associated with lower incidence of nodal spread. Additionally, higher NLR in nodal-positive patients was correlated with shorter survival.
SCIENTIFIC REPORTS
(2023)
Review
Urology & Nephrology
Oscar R. Brouwer, Maarten Albersen, Arie Parnham, Chris Protzel, Curtis A. Pettaway, Benjamin Ayres, Tiago Antunes-Lopes, Lenka Barreto, Riccardo Campi, Juanita Crook, Sergio Fernandez-Pello, Isabella Greco, Michiel S. van der Heijden, Peter A. S. Johnstone, Mithun Kailavasan, Kenneth Manzie, Jack David Marcus, Andrea Necchi, Pedro Oliveira, John Osborne, Lance C. Pagliaro, Herney A. Garcia-Perdomo, R. Bryan Rumble, Ashwin Sachdeva, Vasileios I. Sakalis, Lukasz Zapala, Diego F. Sanchez Martinez, Philippe E. Spiess, Scott T. Tagawa
Summary: Penile cancer is a rare disease with a significant impact on quality of life. This collaborative guideline aims to provide worldwide physician and patient guidance for managing penile cancer, offering updated information on diagnosis and treatment. The incidence of penile cancer is increasing globally, and human papillomavirus (HPV) is the main risk factor.
Article
Biochemistry & Molecular Biology
Lukasz Zapala, Grzegorz Niemczyk, Piotr Zapala, Artur Wdowiak, Iwona Bojar, Tomasz Kluz, Aleksandra Szopa, Anna Serefko, Piotr Radziszewski, Andrzej Wrobel
Summary: This paper aimed to investigate whether the selective cannabinoid CB1 receptor agonist ACEA could reverse the effects of corticosterone (CORT) on depressive and overactive bladder potential. Through experiments on 48 female rats, it was found that ACEA could restore CORT-induced bladder dysfunction and depressive behavior, as well as regulate urine and other biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrzej Wozniak, Slawomir Wozniak, Ewa Poleszak, Tomasz Kluz, Lukasz Zapala, Aleksander Wozniak, Tomasz Rechberger, Andrzej Wrobel
Summary: The postmenopausal state affects a large percentage of women's lives and many experience GSM symptoms such as vaginal dryness, itching, inflammations, lack of elasticity, or dyspareunia. This study found that fractional CO2 laser treatment effectively improved these symptoms and increased the quality of life for women. The treatment restored the correct structure and composition of the vaginal epithelium, leading to positive results in both objective and subjective evaluations.
Article
Biochemistry & Molecular Biology
Paulina Iwaniak, Piotr Dobrowolski, Jan Wrobel, Tomasz Kluz, Artur Wdowiak, Iwona Bojar, Klaudia Stangel-Wojcikiewicz, Ewa Poleszak, Artur Jakimiuk, Marcin Misiek, Lukasz Zapala, Andrzej Wrobel
Summary: The study suggests that imperatorin has the potential to alleviate the symptoms of overactive bladder syndrome and improve bladder function and biochemical changes. Its mechanisms of action are diverse and complex, making it a promising candidate for the treatment of OAB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Oncology
Aimin Jiang, Lukasz Zapala, Le Qu, Linhui Wang
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Agnieszka Goral, Marta Sledz, Aneta Manda-Handzlik, Adrianna Cieloch, Alicja Wojciechowska, Mieszko Lachota, Agnieszka Mroczek, Urszula Demkow, Radoslaw Zagozdzon, Katarzyna Matusik, Malgorzata Wachowska, Angelika Muchowicz
Summary: The crosstalk between Treg and neutrophils may play an important role in CLL progression by interfering with the immune response.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Le Qu, Hui Chen, Qi Chen, Silun Ge, Aimin Jiang, Nengwang Yu, Yulin Zhou, Michal Kunc, Ye Zhou, Xiang Feng, Wei Zhai, Zhenjie Wu, Miaoxia He, Yaoming Li, Rui Chen, Bo Han, Xing Zeng, Yao Fu, Changwei Ji, Xiang Fan, Guangyuan Zhang, Cheng Zhao, Taile Jing, Chenchen Feng, Hongwei Zhao, Di Sun, Liang Wang, Sheng Tai, Cheng Zhang, Shaohao Chen, Yixun Liu, Haifeng Wang, Jinli Gao, Yufeng Gu, He Miao, Tangliang Zhao, Xiaoming Yi, Chaopeng Tang, Dian Fu, Haowei He, Qiu Rao, Wenquan Zhou, Ning Xu, Gongxian Wang, Chaozhao Liang, Zhiyu Liu, Dan Xia, Xiongbing Zu, Ming Chen, Hongqian Guo, Weijun Qin, Zhe Wang, Wei Xue, Benkang Shi, Shaogang Wang, Junhua Zheng, Cheng Chen, Lukasz Zapala, Jingping Ge, Linhui Wang
Summary: Through whole-exome sequencing, it was found that metastases in nonmetastatic ccRCC patients mainly originated from venous tumor thrombus (VTT) rather than primary tumors. Pathological grading of VTT outperformed other indicators in risk assessment. A new prognostic tool, TT-GPS score, incorporating VTT grading, showed better discriminatory ability in predicting the survival of nonmetastatic ccRCC patients with VTT compared to previously reported models.
Review
Urology & Nephrology
Evangelos N. Symeonidis, Domenico Veneziano, Hendrik Borgmann, Lukasz Zapata, Athanasios Zachariou, Horst Brenneis, Stefan M. Haensel, Helmut Haas, Fotios Dimitriadis
Summary: This article examines the past, present, and future roles of telemedicine in urology. The evidence supports telemedicine as a viable, safe, and convenient alternative to in-person clinical visits for most urological diagnoses.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Review
Urology & Nephrology
Piotr Zapala, Aleksander Slusarczyk, Pawel Rajwa, Giorgio Gandaglia, Lukasz Zapala, Fabio Zattoni, Tomasz Lorenc, Guillaume Ploussard, Piotr Radziszewski
Summary: This systematic review and meta-analysis evaluated the reliability of MRI as a staging tool for radio-recurrent prostate cancer. The results showed that MRI has low sensitivity but high specificity in detecting extracapsular extension, seminal vesical invasion, and nodal involvement. However, the limited number of studies and heterogeneity of the data suggest the need for more research.
WORLD JOURNAL OF UROLOGY
(2023)
