Activation and Regulation of the Pattern Recognition Receptors in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance

Adipose Tissue Macrophages Function As Antigen-Presenting Cells and Regulate Adipose Tissue CD4 + T Cells in Mice

(2013) David L. Morris et al.   DIABETES

Association Between Specific Adipose Tissue CD4+ T-Cell Populations and Insulin Resistance in Obese Individuals

(2013) Elisa Fabbrini et al.   GASTROENTEROLOGY

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

(2013) T. Galbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

(2013) Triantafyllos Chavakis et al.   THROMBOSIS AND HAEMOSTASIS

Chronic adipose tissue inflammation: all immune cells on the stage

(2013) Gökhan Cildir et al.   TRENDS IN MOLECULAR MEDICINE

Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity

(2013) Ravid Shechter et al.   Scientific Reports

The TLR family protein RP105/MD-1 complex

(2013) Yoshinori Nagai et al.   Adipocyte

Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases

(2012) Ricardo G. Correa et al.   BIOSCIENCE REPORTS

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

(2012) Karen K. Ryan et al.   Cell Metabolism

Selective Insulin and Leptin Resistance in Metabolic Disorders

(2012) A. Christine Könner et al.   Cell Metabolism

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Nod-like receptors in the control of intestinal inflammation

(2012) Stephen J Rubino et al.   CURRENT OPINION IN IMMUNOLOGY

The Radioprotective 105/MD-1 Complex Contributes to Diet-Induced Obesity and Adipose Tissue Inflammation

(2012) Yasuharu Watanabe et al.   DIABETES

Central Resistin Overexposure Induces Insulin Resistance Through Toll-Like Receptor 4

(2012) Yacir Benomar et al.   DIABETES

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Effects of glucocorticoids and exercise on pancreatic β-cell function and diabetes development

(2012) Jacqueline L. Beaudry et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A

(2012) N. Yamakawa et al.   INTERNATIONAL IMMUNOLOGY

The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells

(2012) Y. Nagai et al.   INTERNATIONAL IMMUNOLOGY

NLRs, inflammasomes, and viral infection

(2012) S. R. Jacobs et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Give a NOD to insulin resistance

(2011) Jonathan D. Schertzer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications

(2011) Chun Zeng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Immunity as a link between obesity and insulin resistance

(2011) Nishan S. Kalupahana et al.   MOLECULAR ASPECTS OF MEDICINE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

NLR functions beyond pathogen recognition

(2011) Thomas A Kufer et al.   NATURE IMMUNOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

Obesity, insulin resistance and free fatty acids

(2011) Guenther Boden   Current Opinion in Endocrinology Diabetes and Obesity

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

(2011) Andréa M. Caricilli et al.   PLOS BIOLOGY

NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

(2010) Suman Dasgupta et al.   BIOCHEMICAL JOURNAL

The Inflammasomes

(2010) Kate Schroder et al.   CELL

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Adipocyte-myocyte crosstalk in skeletal muscle insulin resistance; is there a role for thyroid hormone?

(2010) Bas Havekes et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Toll-like receptors regulate B cell cytokine production in patients with diabetes

(2010) M. Jagannathan et al.   DIABETOLOGIA

Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse

(2010) L.-H. Kuo et al.   DIABETOLOGIA

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

(2010) Akhilesh K. Tamrakar et al.   ENDOCRINOLOGY

Gut microbiota and obesity

(2010) Emidio Scarpellini et al.   Internal and Emergency Medicine

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

(2010) M. Jagannathan-Bogdan et al.   JOURNAL OF IMMUNOLOGY

Adipose tissue macrophages: their role in adipose tissue remodeling

(2010) Takayoshi Suganami et al.   JOURNAL OF LEUKOCYTE BIOLOGY

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RP105 Facilitates Macrophage Activation by Mycobacterium tuberculosis Lipoproteins

(2009) Antje Blumenthal et al.   Cell Host & Microbe

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Hepatic insulin resistance, metabolic syndrome and cardiovascular disease

(2009) Reza Meshkani et al.   CLINICAL BIOCHEMISTRY

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

(2009) A. Gonzalez-Rodriguez et al.   DIABETES

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Tlr2 is critical for diet-induced metabolic syndrome in a murine model

(2009) Ryan W. Himes et al.   FASEB JOURNAL

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune responses of TLR5+ lamina propria dendritic cells in enterobacterial infection

(2009) Satoshi Uematsu et al.   JOURNAL OF GASTROENTEROLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

NLR, the nucleotide-binding domain leucine-rich repeat containing gene family

(2008) Zhengmao Ye et al.   CURRENT OPINION IN IMMUNOLOGY

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

(2008) Andréa M Caricilli et al.   JOURNAL OF ENDOCRINOLOGY

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

(2008) Martina Proell et al.   PLoS One