Effects of glucocorticoids and exercise on pancreatic β-cell function and diabetes development

Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids

(2012) Anna M. D'souza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats

(2011) Rhianna C. Laker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Voluntary running exercise prevents β-cell failure in susceptible islets of the Zucker diabetic fatty rat

(2011) Viviane Delghingaro-Augusto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose tolerance, insulin sensitivity and  -cell function in patients with rheumatoid arthritis treated with or without low-to-medium dose glucocorticoids

(2011) J. N. Hoes et al.   ANNALS OF THE RHEUMATIC DISEASES

Effects of lifestyle intervention in persons at risk for type 2 diabetes mellitus - results from a randomised, controlled trial

(2011) Vegard Nilsen et al.   BMC PUBLIC HEALTH

Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells

(2011) Margot M.L. Linssen et al.   CELLULAR SIGNALLING

Glucocorticoid-induced diabetes and adrenal suppression: How to detect and manage them

(2011) M. C. LANSANG et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Glucagon-Like Peptide-1 Receptor Agonist Treatment Prevents Glucocorticoid-Induced Glucose Intolerance and Islet-Cell Dysfunction in Humans

(2011) D. H. van Raalte et al.   DIABETES CARE

Glucolipotoxicity and beta cells in type 2 diabetes mellitus: Target for durable therapy?

(2011) Daniel H. van Raalte et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial

(2011) D. H. van Raalte et al.   DIABETOLOGIA

A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding

(2011) Y. Shpilberg et al.   Disease Models & Mechanisms

Morphofunctional Alterations in Endocrine Pancreas of Short- and Long-term Dexamethasone-treated Rats

(2011) A. Rafacho et al.   HORMONE AND METABOLIC RESEARCH

Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes

(2011) Marc G. Jeschke et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

The effects of glucocorticoids on adipose tissue lipid metabolism

(2011) Ashley J. Peckett et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats

(2010) Jonathan E. Campbell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets

(2010) Catriona Kelly et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

(2010) Stephen C. Hanley et al.   ENDOCRINOLOGY

Acute and 2-week exposure to prednisolone impair different aspects of β-cell function in healthy men

(2010) Daniël H van Raalte et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Reduced Glucose Tolerance and Insulin Resistance Induced by Steroid Treatment, Relative Physical Inactivity, and High-Calorie Diet Impairs the Incretin Effect in Healthy Subjects

(2010) K. B. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Islet architecture: A comparative study

(2010) Abraham Kim et al.   Islets

Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats

(2010) Camila Aparecida Machado de Oliveira et al.   Islets

The Role of Physical Activity in Type 2 Diabetes Prevention: Physiological and Practical Perspectives

(2010) Jamie F. Burr et al.   PHYSICIAN AND SPORTSMEDICINE

High doses of dexamethasone induce increased β-cell proliferation in pancreatic rat islets

(2009) Alex Rafacho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats

(2009) Michael A. Király et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcription factors involved in glucose-stimulated insulin secretion of pancreatic beta cells

(2009) Shiying Shao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Exercise Training Intensity on Pancreatic  -Cell Function

(2009) C. A. Slentz et al.   DIABETES CARE

One-Year Treatment With Exenatide Improves  -Cell Function, Compared With Insulin Glargine, in Metformin-Treated Type 2 Diabetic Patients: A randomized, controlled trial

(2009) M. C. Bunck et al.   DIABETES CARE

Adult human β-cell neogenesis?

(2009) C. Demeterco et al.   DIABETES OBESITY & METABOLISM

Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?

(2009) D. H. van Raalte et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Minireview: Meeting the Demand for Insulin: Molecular Mechanisms of Adaptive Postnatal ß-Cell Mass Expansion

(2009) Mira M. Sachdeva et al.   MOLECULAR ENDOCRINOLOGY

Inflexibility in Intramuscular Triglyceride Fractional Synthesis Distinguishes Prediabetes From Obesity in Humans

(2009) Leigh Perreault et al.   Obesity

Adaptation to intermittent stress promotes maintenance of β-cell compensation: comparison with food restriction

(2008) Holly E. Bates et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

The Interplay of Prolactin and the Glucocorticoids in the Regulation of β-Cell Gene Expression, Fatty Acid Oxidation, and Glucose-Stimulated Insulin Secretion: Implications for Carbohydrate Metabolism in Pregnancy

(2008) Ramamani Arumugam et al.   ENDOCRINOLOGY

Improved Lactational Nutrition and Postnatal Growth Ameliorates Impairment of Glucose Tolerance by Uteroplacental Insufficiency in Male Rat Offspring

(2008) Andrew L. Siebel et al.   ENDOCRINOLOGY

Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats

(2008) Alex Rafacho et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training

(2008) Jonathan E. Campbell et al.   JOURNAL OF APPLIED PHYSIOLOGY

Sub-chronic stimulation of glucocorticoid receptor impairs and mineralocorticoid receptor protects cytosolic Ca2+ responses to glucose in pancreatic β-cells

(2008) Masaru Koizumi et al.   JOURNAL OF ENDOCRINOLOGY

Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of β-cell function

(2007) Michael A. Király et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM